CO5070675A1 - Pirroles sustituidos - Google Patents

Pirroles sustituidos

Info

Publication number
CO5070675A1
CO5070675A1 CO99015752A CO99015752A CO5070675A1 CO 5070675 A1 CO5070675 A1 CO 5070675A1 CO 99015752 A CO99015752 A CO 99015752A CO 99015752 A CO99015752 A CO 99015752A CO 5070675 A1 CO5070675 A1 CO 5070675A1
Authority
CO
Colombia
Prior art keywords
pirroles
replaced
methyl
hydrogen
pharmaceutically acceptable
Prior art date
Application number
CO99015752A
Other languages
English (en)
Inventor
Hooda Dhingra Urvashi
Donna Mary Huryn
Ke June
Giusseppe Federico Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5070675A1 publication Critical patent/CO5070675A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula<EMI FILE="99015752_1" ID="1" IMF=JPEG >en la que R1 es hidrógeno y R2 es metilo oR1 es metilo y R2 es hidrógeno oR1 es hidroximetilo y R2 es metiloasí como profármacos farmacéuticamente aceptables o sales farmacéuticamente aceptables de los mismos.
CO99015752A 1998-03-17 1999-03-15 Pirroles sustituidos CO5070675A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7833198P 1998-03-17 1998-03-17

Publications (1)

Publication Number Publication Date
CO5070675A1 true CO5070675A1 (es) 2001-08-28

Family

ID=22143350

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99015752A CO5070675A1 (es) 1998-03-17 1999-03-15 Pirroles sustituidos

Country Status (34)

Country Link
US (1) US6048887A (es)
EP (1) EP1064279B1 (es)
JP (2) JP5026633B2 (es)
KR (1) KR100659411B1 (es)
CN (1) CN1127500C (es)
AR (1) AR018162A1 (es)
AT (1) ATE243693T1 (es)
AU (1) AU755673B2 (es)
BR (1) BR9908882A (es)
CA (1) CA2322689C (es)
CO (1) CO5070675A1 (es)
CZ (1) CZ299068B6 (es)
DE (1) DE69909068T2 (es)
DK (1) DK1064279T3 (es)
ES (1) ES2203111T3 (es)
HK (1) HK1036452A1 (es)
HR (1) HRP20000585B1 (es)
HU (1) HU228831B1 (es)
ID (1) ID26353A (es)
IL (1) IL138247A (es)
MA (1) MA26613A1 (es)
MY (1) MY121046A (es)
NO (1) NO320306B1 (es)
NZ (1) NZ506476A (es)
PE (1) PE20000340A1 (es)
PL (1) PL195323B1 (es)
PT (1) PT1064279E (es)
RS (1) RS49965B (es)
RU (1) RU2208612C2 (es)
SA (1) SA99191295B1 (es)
TR (1) TR200002580T2 (es)
TW (1) TW539676B (es)
WO (1) WO1999047518A1 (es)
ZA (1) ZA992072B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200002580T2 (tr) * 1998-03-17 2000-11-21 F.Hoffmann-La Roche Ag Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
PL357441A1 (en) * 1999-10-12 2004-07-26 F.Hoffmann-La Roche Ag Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
US6482847B2 (en) 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6469179B1 (en) 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
WO2008117935A1 (en) * 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same
CN102924437B (zh) * 2012-11-19 2014-07-02 东华大学 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
TR200002580T2 (tr) * 1998-03-17 2000-11-21 F.Hoffmann-La Roche Ag Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler

Also Published As

Publication number Publication date
YU55200A (sh) 2002-11-15
PL195323B1 (pl) 2007-09-28
KR100659411B1 (ko) 2006-12-18
HU228831B1 (en) 2013-05-28
ATE243693T1 (de) 2003-07-15
WO1999047518A1 (en) 1999-09-23
HUP0101258A3 (en) 2002-08-28
ID26353A (id) 2000-12-14
PT1064279E (pt) 2003-10-31
TR200002580T2 (tr) 2000-11-21
HUP0101258A2 (hu) 2001-10-28
US6048887A (en) 2000-04-11
NO20004579L (no) 2000-09-14
DE69909068D1 (de) 2003-07-31
CZ299068B6 (cs) 2008-04-16
PL342964A1 (en) 2001-07-16
CN1293671A (zh) 2001-05-02
NZ506476A (en) 2003-12-19
DE69909068T2 (de) 2004-05-06
RU2208612C2 (ru) 2003-07-20
DK1064279T3 (da) 2003-10-06
NO320306B1 (no) 2005-11-21
SA99191295B1 (ar) 2006-04-26
AU3409999A (en) 1999-10-11
CA2322689A1 (en) 1999-09-23
CA2322689C (en) 2008-11-25
JP2002506864A (ja) 2002-03-05
NO20004579D0 (no) 2000-09-14
MA26613A1 (fr) 2004-12-20
JP5026633B2 (ja) 2012-09-12
EP1064279B1 (en) 2003-06-25
IL138247A0 (en) 2001-10-31
RS49965B (sr) 2008-09-29
EP1064279A1 (en) 2001-01-03
CN1127500C (zh) 2003-11-12
PE20000340A1 (es) 2000-05-13
HK1036452A1 (en) 2002-01-04
HRP20000585A2 (en) 2001-08-31
AU755673B2 (en) 2002-12-19
TW539676B (en) 2003-07-01
HRP20000585B1 (en) 2009-02-28
CZ20003384A3 (cs) 2000-12-13
IL138247A (en) 2005-08-31
BR9908882A (pt) 2000-11-21
ES2203111T3 (es) 2004-04-01
ZA992072B (en) 1999-09-22
JP2010222366A (ja) 2010-10-07
MY121046A (en) 2005-12-30
KR20010041995A (ko) 2001-05-25
AR018162A1 (es) 2001-10-31

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