NO20004579D0 - Substituerte bisindolymaleimider for inhibering av celle- proliferering - Google Patents
Substituerte bisindolymaleimider for inhibering av celle- prolifereringInfo
- Publication number
- NO20004579D0 NO20004579D0 NO20004579A NO20004579A NO20004579D0 NO 20004579 D0 NO20004579 D0 NO 20004579D0 NO 20004579 A NO20004579 A NO 20004579A NO 20004579 A NO20004579 A NO 20004579A NO 20004579 D0 NO20004579 D0 NO 20004579D0
- Authority
- NO
- Norway
- Prior art keywords
- bisindolymalimides
- substituted
- cell proliferation
- inhibit cell
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7833198P | 1998-03-17 | 1998-03-17 | |
| PCT/EP1999/001534 WO1999047518A1 (en) | 1998-03-17 | 1999-03-10 | Substituted bisindolymaleimides for the inhibition of cell proliferation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004579L NO20004579L (no) | 2000-09-14 |
| NO20004579D0 true NO20004579D0 (no) | 2000-09-14 |
| NO320306B1 NO320306B1 (no) | 2005-11-21 |
Family
ID=22143350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004579A NO320306B1 (no) | 1998-03-17 | 2000-09-14 | Substituerte bisindolymaleimider for inhibering av celle-proliferering |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6048887A (no) |
| EP (1) | EP1064279B1 (no) |
| JP (2) | JP5026633B2 (no) |
| KR (1) | KR100659411B1 (no) |
| CN (1) | CN1127500C (no) |
| AR (1) | AR018162A1 (no) |
| AT (1) | ATE243693T1 (no) |
| AU (1) | AU755673B2 (no) |
| BR (1) | BR9908882A (no) |
| CA (1) | CA2322689C (no) |
| CO (1) | CO5070675A1 (no) |
| CZ (1) | CZ299068B6 (no) |
| DE (1) | DE69909068T2 (no) |
| DK (1) | DK1064279T3 (no) |
| ES (1) | ES2203111T3 (no) |
| HK (1) | HK1036452A1 (no) |
| HR (1) | HRP20000585B1 (no) |
| HU (1) | HU228831B1 (no) |
| ID (1) | ID26353A (no) |
| IL (1) | IL138247A (no) |
| MA (1) | MA26613A1 (no) |
| MY (1) | MY121046A (no) |
| NO (1) | NO320306B1 (no) |
| NZ (1) | NZ506476A (no) |
| PE (1) | PE20000340A1 (no) |
| PL (1) | PL195323B1 (no) |
| PT (1) | PT1064279E (no) |
| RS (1) | RS49965B (no) |
| RU (1) | RU2208612C2 (no) |
| SA (1) | SA99191295B1 (no) |
| TR (1) | TR200002580T2 (no) |
| TW (1) | TW539676B (no) |
| WO (1) | WO1999047518A1 (no) |
| ZA (1) | ZA992072B (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE243693T1 (de) * | 1998-03-17 | 2003-07-15 | Hoffmann La Roche | Substituierte bisindolylmaleimide zur inhibierung der zellproliferation |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| MXPA02003667A (es) * | 1999-10-12 | 2002-08-30 | Hoffmann La Roche | Pirroles sustituidos como agentes antiproliferativos para tratamiento del cancer. |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| US6482847B2 (en) | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6469179B1 (en) | 2000-10-03 | 2002-10-22 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6548531B2 (en) | 2001-02-09 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for cancer therapy |
| WO2002102373A1 (en) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Method for administration of cancer therapeutic |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| WO2008117935A1 (en) * | 2007-03-28 | 2008-10-02 | Industry-Academic Cooperation Foundation, Yonsei University | Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same |
| CN102924437B (zh) * | 2012-11-19 | 2014-07-02 | 东华大学 | 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用 |
| WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| EP1449529B1 (en) * | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Protein Kinase C Inhibitors |
| PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
| ATE243693T1 (de) * | 1998-03-17 | 2003-07-15 | Hoffmann La Roche | Substituierte bisindolylmaleimide zur inhibierung der zellproliferation |
-
1999
- 1999-03-10 AT AT99915558T patent/ATE243693T1/de active
- 1999-03-10 HU HU0101258A patent/HU228831B1/hu unknown
- 1999-03-10 WO PCT/EP1999/001534 patent/WO1999047518A1/en active IP Right Grant
- 1999-03-10 TR TR2000/02580T patent/TR200002580T2/xx unknown
- 1999-03-10 DK DK99915558T patent/DK1064279T3/da active
- 1999-03-10 JP JP2000536713A patent/JP5026633B2/ja not_active Expired - Lifetime
- 1999-03-10 CN CN99804045A patent/CN1127500C/zh not_active Expired - Lifetime
- 1999-03-10 PT PT99915558T patent/PT1064279E/pt unknown
- 1999-03-10 DE DE69909068T patent/DE69909068T2/de not_active Expired - Lifetime
- 1999-03-10 EP EP99915558A patent/EP1064279B1/en not_active Expired - Lifetime
- 1999-03-10 IL IL13824799A patent/IL138247A/xx not_active IP Right Cessation
- 1999-03-10 AU AU34099/99A patent/AU755673B2/en not_active Expired
- 1999-03-10 RU RU2000125889/04A patent/RU2208612C2/ru active
- 1999-03-10 NZ NZ506476A patent/NZ506476A/en not_active IP Right Cessation
- 1999-03-10 KR KR1020007010323A patent/KR100659411B1/ko not_active IP Right Cessation
- 1999-03-10 CA CA002322689A patent/CA2322689C/en not_active Expired - Lifetime
- 1999-03-10 ES ES99915558T patent/ES2203111T3/es not_active Expired - Lifetime
- 1999-03-10 ID IDW20001730A patent/ID26353A/id unknown
- 1999-03-10 RS YUP-552/00A patent/RS49965B/sr unknown
- 1999-03-10 BR BR9908882-7A patent/BR9908882A/pt not_active Application Discontinuation
- 1999-03-10 PL PL342964A patent/PL195323B1/pl unknown
- 1999-03-10 CZ CZ20003384A patent/CZ299068B6/cs not_active IP Right Cessation
- 1999-03-12 MA MA25492A patent/MA26613A1/fr unknown
- 1999-03-12 PE PE1999000199A patent/PE20000340A1/es not_active IP Right Cessation
- 1999-03-15 MY MYPI99000952A patent/MY121046A/en unknown
- 1999-03-15 ZA ZA9902072A patent/ZA992072B/xx unknown
- 1999-03-15 AR ARP990101117A patent/AR018162A1/es active IP Right Grant
- 1999-03-15 CO CO99015752A patent/CO5070675A1/es unknown
- 1999-03-15 TW TW088103914A patent/TW539676B/zh not_active IP Right Cessation
- 1999-03-16 US US09/268,887 patent/US6048887A/en not_active Expired - Lifetime
- 1999-04-13 SA SA99191295A patent/SA99191295B1/ar unknown
-
2000
- 2000-09-06 HR HR20000585A patent/HRP20000585B1/xx not_active IP Right Cessation
- 2000-09-14 NO NO20004579A patent/NO320306B1/no not_active IP Right Cessation
-
2001
- 2001-10-15 HK HK01107189A patent/HK1036452A1/xx not_active IP Right Cessation
-
2010
- 2010-06-02 JP JP2010126632A patent/JP2010222366A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |