CO5080758A1 - DERIVADOS DE 3-(2-oxo-[1,3´]BIPIRROLODINIL-3-ILIDENMETIL - Google Patents

DERIVADOS DE 3-(2-oxo-[1,3´]BIPIRROLODINIL-3-ILIDENMETIL

Info

Publication number
CO5080758A1
CO5080758A1 CO99036886A CO99036886A CO5080758A1 CO 5080758 A1 CO5080758 A1 CO 5080758A1 CO 99036886 A CO99036886 A CO 99036886A CO 99036886 A CO99036886 A CO 99036886A CO 5080758 A1 CO5080758 A1 CO 5080758A1
Authority
CO
Colombia
Prior art keywords
ocor
hydrogen
cooch
jpeg
coor
Prior art date
Application number
CO99036886A
Other languages
English (en)
Inventor
Paul Hebeisen
Christian Hubschwerlen
Jean Luc Specklin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5080758A1 publication Critical patent/CO5080758A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Compuestos de fórmula I<EMI FILE="99036886_1" ID="1" IMF=JPEG >Donde R1 es un hidrógeno, C1-6-alquilo, sustituido opcionalmente por flúor, o bien el C3-6 -cicloalquilo;R2 es un hidrógeno o un grupo elegido entre -CH2C(=CHR)-COOR, -CH2OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CH2COCH2 OCOR y<EMI FILE="99036886_2" ID="2" IMF=JPEG >R3 es un hidrógeno o un grupo elegido entre -CH2C(=CH2)-COOR, -COOCH2C(=CHR)-COOR, -COOCH2OCOR, -COOCH(R)OCOR, -COOCH(R)OCOOR, -COOCH(OCOR)OCOR, -COOCH2 COCH2 OCOR, y<EMI FILE="99036886_3" ID="3" IMF=JPEG >con la condición de que R2 o R3 sea un hidrógeno y el otro R2 o R3 sea distinto de un hidrógeno,R es un hidrógeno o C1-6-alquilo;R4 es un hidrógeno o un grupo hidroxi,R5 es un hidrógeno o un ?-hidroxialquilo; yX es CH ó N,así como sales de dichos compuestos aceptables farmacéuticamente e hidratos de los compuestos de fórmula I y de sus sales.
CO99036886A 1998-06-15 1999-06-11 DERIVADOS DE 3-(2-oxo-[1,3´]BIPIRROLODINIL-3-ILIDENMETIL CO5080758A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110888 1998-06-15
EP98117099 1998-09-10

Publications (1)

Publication Number Publication Date
CO5080758A1 true CO5080758A1 (es) 2001-09-25

Family

ID=26149347

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99036886A CO5080758A1 (es) 1998-06-15 1999-06-11 DERIVADOS DE 3-(2-oxo-[1,3´]BIPIRROLODINIL-3-ILIDENMETIL

Country Status (28)

Country Link
EP (1) EP1087980B1 (es)
JP (1) JP3872955B2 (es)
KR (1) KR100411915B1 (es)
CN (1) CN1136222C (es)
AR (1) AR018675A1 (es)
AT (1) ATE231871T1 (es)
AU (1) AU754732B2 (es)
BE (1) BE2014C034I2 (es)
BR (2) BRPI9911178B8 (es)
CA (1) CA2334568C (es)
CO (1) CO5080758A1 (es)
DE (1) DE69905162T2 (es)
DK (1) DK1087980T3 (es)
ES (1) ES2190222T3 (es)
FR (1) FR14C0044I2 (es)
GT (1) GT199900084A (es)
HU (1) HUP0105426A3 (es)
ID (1) ID27686A (es)
IL (1) IL139872A0 (es)
LU (1) LU92564I2 (es)
MA (1) MA26650A1 (es)
NO (1) NO20006350L (es)
PA (1) PA8475701A1 (es)
PE (1) PE20000645A1 (es)
PL (1) PL344994A1 (es)
SV (1) SV1999000075A (es)
TN (1) TNSN99114A1 (es)
WO (1) WO1999065920A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004127A1 (en) * 1999-07-07 2001-01-18 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring
DE60123513T2 (de) 2000-04-19 2007-05-10 Basilea Pharmaceutica Ag Verfahren zur Herstellung von D-Asparaginderivaten
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
DK1606293T3 (da) * 2003-03-27 2009-10-05 Basilea Pharmaceutica Ag Cephalosporin i krystallinsk form
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
AR071318A1 (es) 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
CN102448967A (zh) * 2009-05-25 2012-05-09 桑多斯股份公司 生产头孢托罗酯的方法
BR112012028678A2 (pt) 2010-05-10 2015-09-15 Basilea Pharmaceutica Internat Ltd processo de oxidação para preparar derivados de 3-formil-cefem

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2281090T3 (es) * 1996-11-06 2007-09-16 Basilea Pharmaceutica Ag Derivados de vinilpirrolidona-cefalosporina.
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents

Also Published As

Publication number Publication date
DE69905162T2 (de) 2003-12-24
HUP0105426A3 (en) 2002-12-28
KR20010052866A (ko) 2001-06-25
EP1087980B1 (en) 2003-01-29
BR9911178B1 (pt) 2013-10-29
WO1999065920A1 (en) 1999-12-23
EP1087980A1 (en) 2001-04-04
ATE231871T1 (de) 2003-02-15
LU92564I2 (fr) 2014-12-01
SV1999000075A (es) 2000-05-02
MA26650A1 (fr) 2004-12-20
FR14C0044I2 (fr) 2015-02-20
ID27686A (id) 2001-04-19
PA8475701A1 (es) 2000-09-29
PL344994A1 (en) 2001-11-19
CN1305484A (zh) 2001-07-25
JP3872955B2 (ja) 2007-01-24
DK1087980T3 (da) 2003-05-26
KR100411915B1 (ko) 2003-12-18
HUP0105426A2 (hu) 2002-05-29
CN1136222C (zh) 2004-01-28
AU4508199A (en) 2000-01-05
IL139872A0 (en) 2002-02-10
AU754732B2 (en) 2002-11-21
BRPI9911178C1 (pt) 2021-05-25
GT199900084A (es) 2000-12-05
AR018675A1 (es) 2001-11-28
JP2002518401A (ja) 2002-06-25
NO20006350D0 (no) 2000-12-13
BR9911178A (pt) 2001-03-13
TNSN99114A1 (fr) 2005-11-10
BE2014C034I2 (en) 2018-08-24
DE69905162D1 (de) 2003-03-06
FR14C0044I1 (es) 2014-07-18
CA2334568A1 (en) 1999-12-23
BRPI9911178B8 (pt) 2017-03-07
ES2190222T3 (es) 2003-07-16
CA2334568C (en) 2009-02-24
NO20006350L (no) 2000-12-13
PE20000645A1 (es) 2000-07-26

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