BE2014C034I2 - Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems - Google Patents
Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephemsInfo
- Publication number
- BE2014C034I2 BE2014C034I2 BE2014C034C BE2014C034C BE2014C034I2 BE 2014C034 I2 BE2014C034 I2 BE 2014C034I2 BE 2014C034 C BE2014C034 C BE 2014C034C BE 2014C034 C BE2014C034 C BE 2014C034C BE 2014C034 I2 BE2014C034 I2 BE 2014C034I2
- Authority
- BE
- Belgium
- Prior art keywords
- hydrogen
- compounds
- ocor
- coor
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention is concerned with new compounds of formula (I) wherein R<1> is hydrogen, C1-6-alkyl, optionally substituted by fluoro, or C3-6-cycloalkyl; R<2> is hydrogen or a group selected from -CH2C(=CHR)-COOR, -CH2OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CH2COCH2OCOR and (II); R<3> is hydrogen or group selected from -CH2C(=CH2)-COOR, -COOCH2C(=CHR)-COOR, -COOCH2OCOR, -COOCH(R)OCOR, -CO CH(R)OCOOR, -COOCH(OCOR)OCOR, -COOCH2COCH2OCOR, and (III); with the proviso that one of R<2> and R<3> is hydrogen and the other of R<2> and R<3> is different from hydrogen, R is hydrogen or C1-6-alkyl; R<4> is hydrogen or hydroxy, R<5> is hydrogen or omega -hydroxyalkyl; and X is CH or N, as well as pharmaceutically acceptable salts of said compounds and hydrates of said compounds and of their salts, and with the use of compounds of formula (I) and of pharmaceutically acceptable salts of said compounds and hydrates of said compounds and of their salts for the manufacture of pharmaceutical preparations containing such compounds.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98110888 | 1998-06-15 | ||
| EP98117099 | 1998-09-10 | ||
| PCT/EP1999/003907 WO1999065920A1 (en) | 1998-06-15 | 1999-06-07 | Derivatives of 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems |
| EP99927894A EP1087980B1 (en) | 1998-06-15 | 1999-06-07 | Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2014C034I2 true BE2014C034I2 (en) | 2018-08-24 |
Family
ID=26149347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2014C034C BE2014C034I2 (en) | 1998-06-15 | 2014-05-15 | Derivatives of 3-(2-oxo- 1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1087980B1 (en) |
| JP (1) | JP3872955B2 (en) |
| KR (1) | KR100411915B1 (en) |
| CN (1) | CN1136222C (en) |
| AR (1) | AR018675A1 (en) |
| AT (1) | ATE231871T1 (en) |
| AU (1) | AU754732B2 (en) |
| BE (1) | BE2014C034I2 (en) |
| BR (2) | BRPI9911178B8 (en) |
| CA (1) | CA2334568C (en) |
| CO (1) | CO5080758A1 (en) |
| DE (1) | DE69905162T2 (en) |
| DK (1) | DK1087980T3 (en) |
| ES (1) | ES2190222T3 (en) |
| FR (1) | FR14C0044I2 (en) |
| GT (1) | GT199900084A (en) |
| HU (1) | HUP0105426A3 (en) |
| ID (1) | ID27686A (en) |
| IL (1) | IL139872A0 (en) |
| LU (1) | LU92564I2 (en) |
| MA (1) | MA26650A1 (en) |
| NO (1) | NO20006350L (en) |
| PA (1) | PA8475701A1 (en) |
| PE (1) | PE20000645A1 (en) |
| PL (1) | PL344994A1 (en) |
| SV (1) | SV1999000075A (en) |
| TN (1) | TNSN99114A1 (en) |
| WO (1) | WO1999065920A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6267100A (en) * | 1999-07-07 | 2001-01-30 | F. Hoffmann-La Roche Ag | Vinylpyrrolidinone derivatives with substituted thiazole ring |
| DK1148140T3 (en) | 2000-04-19 | 2007-01-08 | Basilea Pharmaceutica Ag | Process for the preparation of D-asparagine derivatives |
| US6504025B2 (en) * | 2000-05-24 | 2003-01-07 | Basilea Pharmaceutica Ag | Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives |
| ATE440101T1 (en) | 2003-03-27 | 2009-09-15 | Basilea Pharmaceutica Ag | CEPHALOSPORIN IN CRYSTALLINE FORM |
| EP1656930A1 (en) | 2004-11-10 | 2006-05-17 | Basilea Pharmaceutica AG | Stabilized freeze-dried formulation for cephalosporin derivatives |
| AR071318A1 (en) | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | BENZHIDRIL ESTER OF THE ACID (6R, 7R) -7- {2- (5-AMINO- [1,2,4] TIADIAZOL-3-IL) -2 - [(Z) -TRITILOXIIMINO] -ACETILAMINO} -3- [ (R) -1'-TERC-BUTOXICARBONIL-2-OXO- [1,3 '] BIPIRROLIDINIL- (3E) -ILIDENOMETIL] -8-OXO-5-TIA-1-AZA-BICICLO [4.2.0] OCT- 2-ENO-2-CARBOXILICO CRISTALINO; YOUR ELABORATION AND USE |
| WO2010072672A1 (en) | 2008-12-24 | 2010-07-01 | Basilea Pharmaceutica Ag | New crystal polymorphs of ceftobiprole |
| EP2435442B1 (en) * | 2009-05-25 | 2016-01-13 | Sandoz AG | Method for producing ceftobiprol medocaril |
| PL2569321T3 (en) | 2010-05-10 | 2015-07-31 | Basilea Pharmaceutica Int Ltd | Oxidation process for preparing 3-formyl-cephem derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0841339T3 (en) * | 1996-11-06 | 2007-07-02 | Basilea Pharmaceutica Ag | Vinylpyrrolidinone-cephalosporin derivatives |
| TW415949B (en) * | 1996-12-19 | 2000-12-21 | Hoffmann La Roche | Vinyl pyrrolidine cephalosporin derivatives with basic substituents |
-
1999
- 1999-06-07 IL IL13987299A patent/IL139872A0/en unknown
- 1999-06-07 EP EP99927894A patent/EP1087980B1/en not_active Expired - Lifetime
- 1999-06-07 AT AT99927894T patent/ATE231871T1/en active
- 1999-06-07 DE DE69905162T patent/DE69905162T2/en not_active Expired - Lifetime
- 1999-06-07 JP JP2000554745A patent/JP3872955B2/en not_active Expired - Lifetime
- 1999-06-07 ES ES99927894T patent/ES2190222T3/en not_active Expired - Lifetime
- 1999-06-07 BR BRPI9911178A patent/BRPI9911178B8/en not_active IP Right Cessation
- 1999-06-07 CN CNB998073474A patent/CN1136222C/en not_active Expired - Lifetime
- 1999-06-07 BR BRPI9911178A patent/BRPI9911178C1/en unknown
- 1999-06-07 CA CA002334568A patent/CA2334568C/en not_active Expired - Lifetime
- 1999-06-07 KR KR10-2000-7014203A patent/KR100411915B1/en not_active IP Right Cessation
- 1999-06-07 HU HU0105426A patent/HUP0105426A3/en unknown
- 1999-06-07 AU AU45081/99A patent/AU754732B2/en not_active Expired
- 1999-06-07 ID IDW20002565A patent/ID27686A/en unknown
- 1999-06-07 DK DK99927894T patent/DK1087980T3/en active
- 1999-06-07 PL PL99344994A patent/PL344994A1/en unknown
- 1999-06-07 WO PCT/EP1999/003907 patent/WO1999065920A1/en active IP Right Grant
- 1999-06-11 CO CO99036886A patent/CO5080758A1/en unknown
- 1999-06-11 AR ARP990102825A patent/AR018675A1/en active IP Right Grant
- 1999-06-11 PE PE1999000521A patent/PE20000645A1/en not_active Application Discontinuation
- 1999-06-14 PA PA19998475701A patent/PA8475701A1/en unknown
- 1999-06-14 GT GT199900084A patent/GT199900084A/en unknown
- 1999-06-15 SV SV1999000075A patent/SV1999000075A/en not_active Application Discontinuation
- 1999-06-15 MA MA25625A patent/MA26650A1/en unknown
- 1999-06-15 TN TNTNSN99114A patent/TNSN99114A1/en unknown
-
2000
- 2000-12-13 NO NO20006350A patent/NO20006350L/en not_active Application Discontinuation
-
2014
- 2014-05-15 BE BE2014C034C patent/BE2014C034I2/en unknown
- 2014-06-11 FR FR14C0044C patent/FR14C0044I2/en active Active
- 2014-10-01 LU LU92564C patent/LU92564I2/en unknown
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