ATE231871T1 - 3-(2-OXO-(1,3')BIPYRROLIDINYL-3-YLIDENE-METHYL)-CEPHEM DERIVATIVES - Google Patents

3-(2-OXO-(1,3')BIPYRROLIDINYL-3-YLIDENE-METHYL)-CEPHEM DERIVATIVES

Info

Publication number
ATE231871T1
ATE231871T1 AT99927894T AT99927894T ATE231871T1 AT E231871 T1 ATE231871 T1 AT E231871T1 AT 99927894 T AT99927894 T AT 99927894T AT 99927894 T AT99927894 T AT 99927894T AT E231871 T1 ATE231871 T1 AT E231871T1
Authority
AT
Austria
Prior art keywords
bipyrrolidinyl
ylidene
oxo
methyl
cephem derivatives
Prior art date
Application number
AT99927894T
Other languages
German (de)
Inventor
Paul Hebeisen
Christian Hubschwerlen
Jean-Luc Specklin
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Application granted granted Critical
Publication of ATE231871T1 publication Critical patent/ATE231871T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
AT99927894T 1998-06-15 1999-06-07 3-(2-OXO-(1,3')BIPYRROLIDINYL-3-YLIDENE-METHYL)-CEPHEM DERIVATIVES ATE231871T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98110888 1998-06-15
EP98117099 1998-09-10
PCT/EP1999/003907 WO1999065920A1 (en) 1998-06-15 1999-06-07 Derivatives of 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems

Publications (1)

Publication Number Publication Date
ATE231871T1 true ATE231871T1 (en) 2003-02-15

Family

ID=26149347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99927894T ATE231871T1 (en) 1998-06-15 1999-06-07 3-(2-OXO-(1,3')BIPYRROLIDINYL-3-YLIDENE-METHYL)-CEPHEM DERIVATIVES

Country Status (28)

Country Link
EP (1) EP1087980B1 (en)
JP (1) JP3872955B2 (en)
KR (1) KR100411915B1 (en)
CN (1) CN1136222C (en)
AR (1) AR018675A1 (en)
AT (1) ATE231871T1 (en)
AU (1) AU754732B2 (en)
BE (1) BE2014C034I2 (en)
BR (2) BRPI9911178B8 (en)
CA (1) CA2334568C (en)
CO (1) CO5080758A1 (en)
DE (1) DE69905162T2 (en)
DK (1) DK1087980T3 (en)
ES (1) ES2190222T3 (en)
FR (1) FR14C0044I2 (en)
GT (1) GT199900084A (en)
HU (1) HUP0105426A3 (en)
ID (1) ID27686A (en)
IL (1) IL139872A0 (en)
LU (1) LU92564I2 (en)
MA (1) MA26650A1 (en)
NO (1) NO20006350L (en)
PA (1) PA8475701A1 (en)
PE (1) PE20000645A1 (en)
PL (1) PL344994A1 (en)
SV (1) SV1999000075A (en)
TN (1) TNSN99114A1 (en)
WO (1) WO1999065920A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004127A1 (en) * 1999-07-07 2001-01-18 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring
DK1148140T3 (en) 2000-04-19 2007-01-08 Basilea Pharmaceutica Ag Process for the preparation of D-asparagine derivatives
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
SI1606293T1 (en) * 2003-03-27 2009-10-31 Basilea Pharmaceutica Ag Cephalosporin in crystalline form
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
AR071318A1 (en) 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag BENZHIDRIL ESTER OF THE ACID (6R, 7R) -7- {2- (5-AMINO- [1,2,4] TIADIAZOL-3-IL) -2 - [(Z) -TRITILOXIIMINO] -ACETILAMINO} -3- [ (R) -1'-TERC-BUTOXICARBONIL-2-OXO- [1,3 '] BIPIRROLIDINIL- (3E) -ILIDENOMETIL] -8-OXO-5-TIA-1-AZA-BICICLO [4.2.0] OCT- 2-ENO-2-CARBOXILICO CRISTALINO; YOUR ELABORATION AND USE
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
ES2565205T3 (en) * 2009-05-25 2016-04-01 Sandoz Ag Method for the production of ceftobiprol medocaril
MX2012012798A (en) 2010-05-10 2013-02-27 Basilea Pharmaceutica Internat Ltd Oxidation process for preparing 3-formyl-cephem derivatives.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0841339B1 (en) * 1996-11-06 2007-02-21 Basilea Pharmaceutica AG Vinylpyrrolidinon cephalosporin derivatives
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents

Also Published As

Publication number Publication date
CO5080758A1 (en) 2001-09-25
PA8475701A1 (en) 2000-09-29
CA2334568C (en) 2009-02-24
BR9911178A (en) 2001-03-13
MA26650A1 (en) 2004-12-20
BRPI9911178C1 (en) 2021-05-25
JP3872955B2 (en) 2007-01-24
EP1087980B1 (en) 2003-01-29
WO1999065920A1 (en) 1999-12-23
FR14C0044I2 (en) 2015-02-20
HUP0105426A2 (en) 2002-05-29
AU754732B2 (en) 2002-11-21
CA2334568A1 (en) 1999-12-23
DE69905162D1 (en) 2003-03-06
BRPI9911178B8 (en) 2017-03-07
AR018675A1 (en) 2001-11-28
ES2190222T3 (en) 2003-07-16
KR20010052866A (en) 2001-06-25
FR14C0044I1 (en) 2014-07-18
AU4508199A (en) 2000-01-05
SV1999000075A (en) 2000-05-02
IL139872A0 (en) 2002-02-10
EP1087980A1 (en) 2001-04-04
CN1305484A (en) 2001-07-25
DE69905162T2 (en) 2003-12-24
HUP0105426A3 (en) 2002-12-28
ID27686A (en) 2001-04-19
GT199900084A (en) 2000-12-05
CN1136222C (en) 2004-01-28
NO20006350D0 (en) 2000-12-13
TNSN99114A1 (en) 2005-11-10
KR100411915B1 (en) 2003-12-18
BR9911178B1 (en) 2013-10-29
LU92564I2 (en) 2014-12-01
PE20000645A1 (en) 2000-07-26
NO20006350L (en) 2000-12-13
BE2014C034I2 (en) 2018-08-24
DK1087980T3 (en) 2003-05-26
JP2002518401A (en) 2002-06-25
PL344994A1 (en) 2001-11-19

Similar Documents

Publication Publication Date Title
ATE435861T1 (en) 12,13-CYCLOPROPANE-EPOTHILONE DERIVATIVES
IS4970A (en) Determines 6,6-hetero-bicyclic derivatives
ATE340176T1 (en) SUBSTITUTED 6,5-HETEROBICYCLIC DERIVATIVES
ID29241A (en) TERANELASI KINOLIN DISTRICTS-1,2
DK1000048T3 (en) Substituted 1,2,3,4-tetrahydronaphthalane derivatives
DE69718771D1 (en) SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALINE DERIVATIVES
FR14C0044I2 (en) 3-(2-OXO-1,3']BIPYRROLIDINYL-3-YLIDENEMETHYL)-CEPHEMES DERIVATIVES
DE69917327D1 (en) 3,3-BIARYLPIPERIDIN AND 3,3-BIARYLMORPHOLINE DERIVATIVES
TR199800988A3 (en) 5 'Deoxy-Citidine derivatives.
EE200000447A (en) 1,3,4-oxadiazolone derivatives
DE60025958D1 (en) 14,15-BETA-METHYLENE SUBSTITUTED ANDROGENE
DK1149106T3 (en) 4,5-azolo-oxindoles
ID26368A (en) DECREASED 2, HYDROMICIN DEXY
ATE240941T1 (en) 1,25-DIHYDROXY-16,22,23-TRISDEHYDRO-CHOLECALCIFEROL DERIVATIVES
FI980405A0 (en) Industriellt, kontinuerligt foerfarande Foer framstaellning av "gravkalk"
MA25138A1 (en) 5- (2-ETHYL-2H-TATRAZOLE-5-YL) -METHYLE-1,2,3,6- TETRAHYDROPURIDINE
DZ2644A1 (en) Triazolo-Ä3,4-aÜ-pyridazine substituted at 1,2,4.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1087980

Country of ref document: EP