DK1087980T3 - 3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivater - Google Patents

3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivater

Info

Publication number
DK1087980T3
DK1087980T3 DK99927894T DK99927894T DK1087980T3 DK 1087980 T3 DK1087980 T3 DK 1087980T3 DK 99927894 T DK99927894 T DK 99927894T DK 99927894 T DK99927894 T DK 99927894T DK 1087980 T3 DK1087980 T3 DK 1087980T3
Authority
DK
Denmark
Prior art keywords
cephemderivater
bipyrrolidinyl
ylidene
oxo
methyl
Prior art date
Application number
DK99927894T
Other languages
English (en)
Inventor
Paul Hebeisen
Christian Hubschwerlen
Jean-Luc Specklin
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Application granted granted Critical
Publication of DK1087980T3 publication Critical patent/DK1087980T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK99927894T 1998-06-15 1999-06-07 3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivater DK1087980T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98110888 1998-06-15
EP98117099 1998-09-10
PCT/EP1999/003907 WO1999065920A1 (en) 1998-06-15 1999-06-07 Derivatives of 3-(2-oxo-[1,3']bipyrrolidinyl-3-ylidenemethyl)-cephems

Publications (1)

Publication Number Publication Date
DK1087980T3 true DK1087980T3 (da) 2003-05-26

Family

ID=26149347

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99927894T DK1087980T3 (da) 1998-06-15 1999-06-07 3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivater

Country Status (28)

Country Link
EP (1) EP1087980B1 (da)
JP (1) JP3872955B2 (da)
KR (1) KR100411915B1 (da)
CN (1) CN1136222C (da)
AR (1) AR018675A1 (da)
AT (1) ATE231871T1 (da)
AU (1) AU754732B2 (da)
BE (1) BE2014C034I2 (da)
BR (2) BRPI9911178B8 (da)
CA (1) CA2334568C (da)
CO (1) CO5080758A1 (da)
DE (1) DE69905162T2 (da)
DK (1) DK1087980T3 (da)
ES (1) ES2190222T3 (da)
FR (1) FR14C0044I2 (da)
GT (1) GT199900084A (da)
HU (1) HUP0105426A3 (da)
ID (1) ID27686A (da)
IL (1) IL139872A0 (da)
LU (1) LU92564I2 (da)
MA (1) MA26650A1 (da)
NO (1) NO20006350D0 (da)
PA (1) PA8475701A1 (da)
PE (1) PE20000645A1 (da)
PL (1) PL344994A1 (da)
SV (1) SV1999000075A (da)
TN (1) TNSN99114A1 (da)
WO (1) WO1999065920A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6267100A (en) * 1999-07-07 2001-01-30 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring
DE60123513T2 (de) 2000-04-19 2007-05-10 Basilea Pharmaceutica Ag Verfahren zur Herstellung von D-Asparaginderivaten
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
ES2329244T3 (es) * 2003-03-27 2009-11-24 Basilea Pharmaceutica Ag Cefalosporina en forma cristalina.
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
AR071318A1 (es) 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
EP2435442B1 (de) * 2009-05-25 2016-01-13 Sandoz AG Verfahren zur herstellung von ceftobiprol medocaril
PT2569321E (pt) 2010-05-10 2015-05-25 Basilea Pharmaceutica Int Ltd Processo de oxidação para a preparação de derivados 3-formil cefeme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE354577T1 (de) * 1996-11-06 2007-03-15 Basilea Pharmaceutica Ag Vinylpyrrolidinon-cephalosporin-derivate
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents

Also Published As

Publication number Publication date
FR14C0044I1 (da) 2014-07-18
NO20006350L (no) 2000-12-13
EP1087980B1 (en) 2003-01-29
CN1305484A (zh) 2001-07-25
JP3872955B2 (ja) 2007-01-24
PE20000645A1 (es) 2000-07-26
TNSN99114A1 (fr) 2005-11-10
ES2190222T3 (es) 2003-07-16
IL139872A0 (en) 2002-02-10
CA2334568C (en) 2009-02-24
NO20006350D0 (no) 2000-12-13
DE69905162T2 (de) 2003-12-24
PL344994A1 (en) 2001-11-19
PA8475701A1 (es) 2000-09-29
DE69905162D1 (de) 2003-03-06
EP1087980A1 (en) 2001-04-04
SV1999000075A (es) 2000-05-02
LU92564I2 (fr) 2014-12-01
AU4508199A (en) 2000-01-05
BE2014C034I2 (en) 2018-08-24
KR100411915B1 (ko) 2003-12-18
JP2002518401A (ja) 2002-06-25
BR9911178A (pt) 2001-03-13
ID27686A (id) 2001-04-19
CN1136222C (zh) 2004-01-28
FR14C0044I2 (fr) 2015-02-20
CA2334568A1 (en) 1999-12-23
AR018675A1 (es) 2001-11-28
MA26650A1 (fr) 2004-12-20
CO5080758A1 (es) 2001-09-25
AU754732B2 (en) 2002-11-21
HUP0105426A2 (hu) 2002-05-29
WO1999065920A1 (en) 1999-12-23
ATE231871T1 (de) 2003-02-15
BR9911178B1 (pt) 2013-10-29
GT199900084A (es) 2000-12-05
HUP0105426A3 (en) 2002-12-28
BRPI9911178C1 (pt) 2021-05-25
KR20010052866A (ko) 2001-06-25
BRPI9911178B8 (pt) 2017-03-07

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