ES2190222T3 - Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem. - Google Patents

Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem.

Info

Publication number
ES2190222T3
ES2190222T3 ES99927894T ES99927894T ES2190222T3 ES 2190222 T3 ES2190222 T3 ES 2190222T3 ES 99927894 T ES99927894 T ES 99927894T ES 99927894 T ES99927894 T ES 99927894T ES 2190222 T3 ES2190222 T3 ES 2190222T3
Authority
ES
Spain
Prior art keywords
hydrogen
ocor
formula
cooch
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99927894T
Other languages
English (en)
Inventor
Paul Hebeisen
Christian Hubschwerlen
Jean-Luc Specklin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Application granted granted Critical
Publication of ES2190222T3 publication Critical patent/ES2190222T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de fórmula I **(Fórmula)** donde R1 es un hidrógeno, C1-6-alquilo, sustituido opcionalmente por flúor, o bien el C3-6-cicloalquilo; R2 es un hidrógeno o un grupo elegido entre -CH2C(=CHR)-COOR, -CH2OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CH2COCH2OCOR y **(Fórmula)** -R3 es un hidrógeno o un grupo elegido entre -CH2C(=CH2)-COOR, -COOCH2C(=CHR)-COOR, -COOCH2OCOR, -COOCH(R)OCOR, -COOCH(R)OCOOR, -COOCH(OCOR)OCOR, -COOCH2COCH2OCOR, y **(Fórmula)** con la condición de que R2 o R3 sea un hidrógeno y el otro R2 o R3 sea distinto de un hidrógeno, R es un hidrógeno o C1-6-alquilo; R4 es un hidrógeno o un grupo hidroxi, R5 es un hidrógeno o un omega-hidroxialquilo; y X es CH ó N, así como sales de dichos compuestos aceptables farmacéuticamente e hidratos de los compuestos de fórmula I y de sus sales.
ES99927894T 1998-06-15 1999-06-07 Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem. Expired - Lifetime ES2190222T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98110888 1998-06-15
EP98117099 1998-09-10

Publications (1)

Publication Number Publication Date
ES2190222T3 true ES2190222T3 (es) 2003-07-16

Family

ID=26149347

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99927894T Expired - Lifetime ES2190222T3 (es) 1998-06-15 1999-06-07 Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem.

Country Status (28)

Country Link
EP (1) EP1087980B1 (es)
JP (1) JP3872955B2 (es)
KR (1) KR100411915B1 (es)
CN (1) CN1136222C (es)
AR (1) AR018675A1 (es)
AT (1) ATE231871T1 (es)
AU (1) AU754732B2 (es)
BE (1) BE2014C034I2 (es)
BR (2) BRPI9911178C1 (es)
CA (1) CA2334568C (es)
CO (1) CO5080758A1 (es)
DE (1) DE69905162T2 (es)
DK (1) DK1087980T3 (es)
ES (1) ES2190222T3 (es)
FR (1) FR14C0044I2 (es)
GT (1) GT199900084A (es)
HU (1) HUP0105426A3 (es)
ID (1) ID27686A (es)
IL (1) IL139872A0 (es)
LU (1) LU92564I2 (es)
MA (1) MA26650A1 (es)
NO (1) NO20006350D0 (es)
PA (1) PA8475701A1 (es)
PE (1) PE20000645A1 (es)
PL (1) PL344994A1 (es)
SV (1) SV1999000075A (es)
TN (1) TNSN99114A1 (es)
WO (1) WO1999065920A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6267100A (en) * 1999-07-07 2001-01-30 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring
DK1148140T3 (da) 2000-04-19 2007-01-08 Basilea Pharmaceutica Ag Fremgangsmåde til fremstilling af D-asparaginderivater
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
JP5230934B2 (ja) * 2003-03-27 2013-07-10 バジリア ファルマスーチカ アーゲー 結晶形態のセファロスポリン
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
AR071318A1 (es) 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
ES2565952T3 (es) * 2009-05-25 2016-04-07 Sandoz Ag Método para la producción de ceftobiprol medocaril
BR112012028678A2 (pt) 2010-05-10 2015-09-15 Basilea Pharmaceutica Internat Ltd processo de oxidação para preparar derivados de 3-formil-cefem

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2281090T3 (es) * 1996-11-06 2007-09-16 Basilea Pharmaceutica Ag Derivados de vinilpirrolidona-cefalosporina.
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents

Also Published As

Publication number Publication date
EP1087980B1 (en) 2003-01-29
JP3872955B2 (ja) 2007-01-24
MA26650A1 (fr) 2004-12-20
AU4508199A (en) 2000-01-05
DE69905162D1 (de) 2003-03-06
DE69905162T2 (de) 2003-12-24
HUP0105426A3 (en) 2002-12-28
PL344994A1 (en) 2001-11-19
ATE231871T1 (de) 2003-02-15
DK1087980T3 (da) 2003-05-26
CA2334568C (en) 2009-02-24
JP2002518401A (ja) 2002-06-25
ID27686A (id) 2001-04-19
BRPI9911178C1 (pt) 2021-05-25
BRPI9911178B8 (pt) 2017-03-07
SV1999000075A (es) 2000-05-02
KR100411915B1 (ko) 2003-12-18
BR9911178B1 (pt) 2013-10-29
NO20006350L (no) 2000-12-13
TNSN99114A1 (fr) 2005-11-10
BE2014C034I2 (en) 2018-08-24
PA8475701A1 (es) 2000-09-29
PE20000645A1 (es) 2000-07-26
CA2334568A1 (en) 1999-12-23
NO20006350D0 (no) 2000-12-13
EP1087980A1 (en) 2001-04-04
AR018675A1 (es) 2001-11-28
IL139872A0 (en) 2002-02-10
GT199900084A (es) 2000-12-05
KR20010052866A (ko) 2001-06-25
LU92564I2 (fr) 2014-12-01
CN1305484A (zh) 2001-07-25
HUP0105426A2 (hu) 2002-05-29
BR9911178A (pt) 2001-03-13
CN1136222C (zh) 2004-01-28
WO1999065920A1 (en) 1999-12-23
CO5080758A1 (es) 2001-09-25
AU754732B2 (en) 2002-11-21
FR14C0044I1 (es) 2014-07-18
FR14C0044I2 (fr) 2015-02-20

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