CO4940443A1 - Analogos de vitamina d3 con dos cadenas laterales sobre el c-20 - Google Patents

Analogos de vitamina d3 con dos cadenas laterales sobre el c-20

Info

Publication number
CO4940443A1
CO4940443A1 CO98022703A CO98022703A CO4940443A1 CO 4940443 A1 CO4940443 A1 CO 4940443A1 CO 98022703 A CO98022703 A CO 98022703A CO 98022703 A CO98022703 A CO 98022703A CO 4940443 A1 CO4940443 A1 CO 4940443A1
Authority
CO
Colombia
Prior art keywords
bond
side chains
double bond
vitamin analogs
fluorcycloalkyl
Prior art date
Application number
CO98022703A
Other languages
English (en)
Inventor
Sarwood Manchand Percy
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4940443A1 publication Critical patent/CO4940443A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/21—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto de la fórmula I:en la que X es H2 o CH2 ; Y es hidrógeno, hidroxi o flúor; Z es hidroxi; R1 y R2 son alquilo o fluoralquilo (C1 -C4 ), o bien R1 y R2 junto con el C25 forman un cicloalquilo o fluorcicloalquilo (C3 -C6 ); R3 y R4 son alquilo o fluoralquilo (C1 -C4 ), o bien R3 y R4 junto con el C25 forman un cicloalquilo o fluorcicloalquilo (C3 -C6 ); A es un enlace simple o un doble enlace; B1 es un enlace simple, un doble enlace trans, un doble enlace cis o un triple enlace; y B2 es un enlace simple, un doble enlace trans, un doble enlace cis o un triple enlace.
CO98022703A 1997-04-28 1998-04-24 Analogos de vitamina d3 con dos cadenas laterales sobre el c-20 CO4940443A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4466197P 1997-04-28 1997-04-28

Publications (1)

Publication Number Publication Date
CO4940443A1 true CO4940443A1 (es) 2000-07-24

Family

ID=21933610

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98022703A CO4940443A1 (es) 1997-04-28 1998-04-24 Analogos de vitamina d3 con dos cadenas laterales sobre el c-20

Country Status (6)

Country Link
US (1) US6030962A (es)
AR (1) AR012598A1 (es)
CO (1) CO4940443A1 (es)
HR (1) HRP980224A2 (es)
PE (1) PE68499A1 (es)
ZA (1) ZA983350B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673782B2 (en) * 1999-04-29 2004-01-06 Wisconsin Alumni Research Foundation Treatment of systemic lupus erythematosis
WO2004098522A2 (en) * 2003-04-30 2004-11-18 Bioxell S.P.A. Gemini vitamin d3 compounds and methods of use thereof
US20050113348A1 (en) * 2003-06-12 2005-05-26 Yanchun Li Vitamin D and vitamin D analogs or derivatives as new anti-hypertensive agents
US20060171983A1 (en) * 2003-07-30 2006-08-03 Jin Tian Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
JP4795023B2 (ja) * 2004-02-03 2011-10-19 中外製薬株式会社 ビタミンｄ化合物及びそれらの合成中間体の合成方法
JP2007525533A (ja) 2004-03-01 2007-09-06 ビオエクセル エスピーエー 間質性膀胱炎の治療方法、並びに関連化合物及び組成物
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
EP1898924A1 (en) * 2005-03-23 2008-03-19 Bioxell S.p.a. Methods of treating osteoporosis and secondary hyperparathyroidism using 20-methyl, gemini vitamin d3 compounds
CA2601914A1 (en) * 2005-03-23 2006-09-28 Bioxell S.P.A. 20-alkyl, gemini vitamin d3 compounds and methods of use thereof
US20090298800A1 (en) * 2005-09-23 2009-12-03 Bioxell S.P.A. 1,25-dihydroxy, 20-cyclopropyl,26-27-deuteroalkyl vitamin d3 compounds and methods of use thereof
US20080280859A1 (en) * 2005-10-19 2008-11-13 Bioxell S.P.A. Gemini vitamin d3 compounds and methods of use thereof
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
US20120184514A1 (en) * 2009-07-01 2012-07-19 Vitamin Derivatives Inc. Vitamin d compounds and methods for preparing same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs

Also Published As

Publication number Publication date
AR012598A1 (es) 2000-11-08
PE68499A1 (es) 1999-07-10
HRP980224A2 (en) 1999-04-30
US6030962A (en) 2000-02-29
ZA983350B (en) 1998-10-28

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