CO5170486A1 - Compuestos de imidazoles sustituidos que tienen actividad an tibacteriana - Google Patents

Compuestos de imidazoles sustituidos que tienen actividad an tibacteriana

Info

Publication number
CO5170486A1
CO5170486A1 CO00038198A CO00038198A CO5170486A1 CO 5170486 A1 CO5170486 A1 CO 5170486A1 CO 00038198 A CO00038198 A CO 00038198A CO 00038198 A CO00038198 A CO 00038198A CO 5170486 A1 CO5170486 A1 CO 5170486A1
Authority
CO
Colombia
Prior art keywords
substituted imidazol
tibacterial
activity
imidazol compounds
compounds
Prior art date
Application number
CO00038198A
Other languages
English (en)
Inventor
Dirk Heerding
Kenneth A Newlander
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO5170486A1 publication Critical patent/CO5170486A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto según la fórmula (I) o la fórmula (II) :<EMI FILE="00038198_1" ID="1" IMF=JPEG >en las que:R1 es alquilo C1-4 , Ar o 2-tienilo o 3-tienilo;R2 es alquilo C1-4 o Ar; yn es 0-3;o una de sus sales farmacéuticamente aceptables.
CO00038198A 1999-05-25 2000-05-24 Compuestos de imidazoles sustituidos que tienen actividad an tibacteriana CO5170486A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13594899P 1999-05-25 1999-05-25

Publications (1)

Publication Number Publication Date
CO5170486A1 true CO5170486A1 (es) 2002-06-27

Family

ID=22470518

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00038198A CO5170486A1 (es) 1999-05-25 2000-05-24 Compuestos de imidazoles sustituidos que tienen actividad an tibacteriana

Country Status (9)

Country Link
US (2) US6559172B1 (es)
EP (1) EP1194144B1 (es)
JP (1) JP4948708B2 (es)
AR (1) AR024077A1 (es)
AT (1) ATE344248T1 (es)
AU (1) AU5043500A (es)
CO (1) CO5170486A1 (es)
DE (1) DE60031682T2 (es)
WO (1) WO2000071120A1 (es)

Families Citing this family (41)

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CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
CA2387016C (en) * 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
US7297708B2 (en) * 2001-09-06 2007-11-20 Bristol-Myers Squibb Company Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス　テック　ファーマ，インコーポレイテッド 治療薬としての置換アゾール誘導体
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
CN1922151A (zh) * 2004-02-12 2007-02-28 特兰斯泰克制药公司 取代的吡咯衍生物、组合物和使用方法
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
US8835476B2 (en) 2005-03-04 2014-09-16 Fan Wu Synthesis of novel antimicrobials
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
JP2009524617A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー 置換２−イミダゾール又はイミダゾリン誘導体の使用
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
AU2007309568A1 (en) * 2006-10-20 2008-05-02 Merck Sharp & Dohme Corp. Substituted imidazoles as bombesin receptor subtype-3 modulators
CA2667003A1 (en) * 2006-10-20 2008-05-02 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
JP5047299B2 (ja) * 2006-10-20 2012-10-10 メルク・シャープ・エンド・ドーム・コーポレイション ボンベシン受容体サブタイプ−３モジュレータとしての置換イミダゾール
EP2125802A4 (en) * 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
JP5313044B2 (ja) * 2008-08-08 2013-10-09 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5301218B2 (ja) * 2008-08-25 2013-09-25 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5484795B2 (ja) * 2008-09-03 2014-05-07 四国化成工業株式会社 ２−ベンジル−４−（３，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5260367B2 (ja) * 2008-09-26 2013-08-14 四国化成工業株式会社 ２−（クロロベンジル）−４−フェニルイミダゾール化合物
MY158622A (en) 2008-10-06 2016-10-31 Shikoku Chem 2-benzyl-4-(2,4-dichlorophenyl)-5-methylimidazole compound
JP5368244B2 (ja) * 2009-10-14 2013-12-18 四国化成工業株式会社 ２−（２，４−ジクロロベンジル）−４−アリール−５−メチルイミダゾール化合物
JP5368263B2 (ja) * 2009-11-04 2013-12-18 四国化成工業株式会社 ４−（２，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5368271B2 (ja) * 2009-11-20 2013-12-18 四国化成工業株式会社 ４−（４−ビフェニリル）−２−（２，４−ジクロロベンジル）イミダゾールおよび表面処理液
JP5398076B2 (ja) * 2009-12-10 2014-01-29 四国化成工業株式会社 ２−（ブロモベンジル）−４−（ブロモフェニル）−５−メチルイミダゾール化合物
JP5398075B2 (ja) * 2010-01-13 2014-01-29 四国化成工業株式会社 ４−（ジクロロフェニル）−２−（４−フルオロベンジル）−５−メチルイミダゾール化合物
JP5615227B2 (ja) * 2011-05-23 2014-10-29 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5615233B2 (ja) * 2011-06-20 2014-10-29 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
IN2014KN02915A (es) 2012-06-19 2015-05-08 Debiopharm Int Sa
JP5892605B2 (ja) * 2012-08-17 2016-03-23 四国化成工業株式会社 ４−（２−チエニル）イミダゾール化合物
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
JP2020530446A (ja) 2017-08-09 2020-10-22 デナリ セラピューティクス インコーポレイテッドＤｅｎａｌｉ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 化合物、組成物、及び、方法
WO2019152977A2 (en) 2018-02-05 2019-08-08 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
MX2021009669A (es) 2019-02-13 2021-10-13 Denali Therapeutics Inc Compuestos, composiciones y métodos.
US20220177456A1 (en) * 2019-03-06 2022-06-09 Denali Therapeutics Inc. Compounds, compositions and methods
JP7479686B2 (ja) 2020-10-16 2024-05-09 株式会社岩や 壁パネル

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US3657441A (en) * 1970-07-30 1972-04-18 Merck & Co Inc Method of inhibiting the formation of phenylethanolamine n-methyl transferase with imidazoles
FR2122395A1 (en) * 1971-01-19 1972-09-01 Berlin Chemie Veb Pharmacologically active imidazoles - by condensing alpha-aminoketones with formamide
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
FR2482859A1 (fr) * 1980-05-22 1981-11-27 Fabre Sa Pierre Fluorhydrates d'heterocycles azotes insatures utilisables en therapeutique dentaire
DE4015535A1 (de) 1990-05-15 1991-11-21 Basf Ag Verfahren zur herstellung von n-substituierten imidazolen
CA2106337C (en) * 1992-09-26 1998-06-16 Hiroyuki Nakanishi Phenylimidazole derivatives, processes for production thereof, herbicides comprising said derivatives, and usages of said herbicides
JP3311858B2 (ja) * 1994-03-08 2002-08-05 四国化成工業株式会社 銅及び銅合金の表面処理剤
JPH10280162A (ja) * 1997-04-07 1998-10-20 Hideaki Yamaguchi プリント配線板の表面保護剤および表面保護膜の形成方法。
EP0996443A1 (en) * 1997-07-03 2000-05-03 Neurogen Corporation Certain diarylimidazole derivatives; a new class of npy specific ligands

Also Published As

Publication number Publication date
EP1194144B1 (en) 2006-11-02
ATE344248T1 (de) 2006-11-15
US20030149089A1 (en) 2003-08-07
JP2003500357A (ja) 2003-01-07
DE60031682T2 (de) 2007-09-06
AU5043500A (en) 2000-12-12
DE60031682D1 (de) 2006-12-14
WO2000071120A1 (en) 2000-11-30
EP1194144A4 (en) 2002-08-07
AR024077A1 (es) 2002-09-04
US6559172B1 (en) 2003-05-06
US6673941B2 (en) 2004-01-06
EP1194144A1 (en) 2002-04-10
JP4948708B2 (ja) 2012-06-06

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