ID29027A - Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv - Google Patents

Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv

Info

Publication number
ID29027A
ID29027A IDW00200101355A ID20011355A ID29027A ID 29027 A ID29027 A ID 29027A ID W00200101355 A IDW00200101355 A ID W00200101355A ID 20011355 A ID20011355 A ID 20011355A ID 29027 A ID29027 A ID 29027A
Authority
ID
Indonesia
Prior art keywords
heteroaromatic
damages
hazard
against hiv
activities against
Prior art date
Application number
IDW00200101355A
Other languages
English (en)
Inventor
Toshio Fujishita
Tomokazu Yoshinaga
Akihito Sato
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of ID29027A publication Critical patent/ID29027A/id

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
IDW00200101355A 1998-12-25 1999-12-17 Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv ID29027A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP37127098 1998-12-25
JP24747999 1999-09-01

Publications (1)

Publication Number Publication Date
ID29027A true ID29027A (id) 2001-07-26

Family

ID=26538287

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW00200101355A ID29027A (id) 1998-12-25 1999-12-17 Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv

Country Status (22)

Country Link
US (3) US6620841B1 (id)
EP (1) EP1142872B1 (id)
JP (1) JP3929244B2 (id)
KR (1) KR20010089708A (id)
CN (1) CN1178913C (id)
AP (1) AP2001002169A0 (id)
AT (1) ATE411286T1 (id)
AU (1) AU763040B2 (id)
BR (1) BR9916583A (id)
CA (1) CA2353961A1 (id)
CZ (1) CZ20012160A3 (id)
DE (1) DE69939749D1 (id)
HK (1) HK1042701A1 (id)
HU (1) HUP0201472A3 (id)
ID (1) ID29027A (id)
IL (1) IL143958A0 (id)
NO (1) NO20013179L (id)
NZ (1) NZ512184A (id)
PL (1) PL348596A1 (id)
RU (1) RU2225860C2 (id)
TR (1) TR200101886T2 (id)
WO (1) WO2000039086A1 (id)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
DE69925918T2 (de) 1998-07-27 2006-05-11 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Diketosäure-derivate als hemmstoffe von polymerasen
GB9816358D0 (en) 1998-07-27 1998-09-23 Angeletti P Ist Richerche Bio Enzyme inhibitors
CN1367784A (zh) 1999-06-02 2002-09-04 盐野义制药株式会社 新的取代丙烯酮衍生物的制备方法
EP1196384A4 (en) * 1999-06-25 2002-10-23 Merck & Co Inc 1- (AROMATIC OR HETEROAROMATICALLY SUBSTITUTED) -3- (HETEROAROMATICALLY SUBSTITUTED) -1,3-PROPANDIONS AND THEIR APPLICATIONS
US20030171406A1 (en) * 2000-06-13 2003-09-11 Akihiko Sato Medicinal compositions containing propenone derivatives
EP1297834A4 (en) * 2000-06-14 2007-05-09 Shionogi & Co ENZYME INHIBITOR HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS
WO2002038771A1 (fr) * 2000-11-09 2002-05-16 Shionogi & Co., Ltd. Integrases du hiv tolerantes aux medicaments
EP3042894A1 (en) * 2001-08-10 2016-07-13 Shionogi & Co., Ltd. Antiviral agent
SI1441735T1 (sl) * 2001-10-26 2006-06-30 Angeletti P Ist Richerche Bio N-substituirani hidroksipirimidinon-karboksamidniinhibitorji HIV-integraze
TW200407132A (en) * 2001-11-15 2004-05-16 Shionogi & Co Process for producing 1-H-1,2,4-triazole-3-carboxylic acid ester
AU2002349675A1 (en) * 2001-12-05 2003-06-17 Shionogi And Co., Ltd. Derivative having hiv integrase inhibitory activity
US7358249B2 (en) 2002-08-13 2008-04-15 Shionogi & Co., Ltd. Heterocyclic compounds having inhibitory activity against HIV integrase
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
CN1569803B (zh) * 2003-07-16 2011-04-13 中国科学院上海药物研究所 芳基β－二酮酸的新制备方法
JP2007529422A (ja) * 2004-01-29 2007-10-25 エリクシアー ファーマシューティカルズ， インコーポレイテッド 抗ウイルス治療
EP2433633A1 (en) * 2004-08-25 2012-03-28 Ardea Biosciences, Inc. Triazolyl alpha -mercaptoacetanildes as inhibitors of HIV reverse transcriptase
EP1790638B1 (en) * 2004-09-15 2013-04-03 Shionogi Co., Ltd. Carbamoylpyridone derivative having hiv integrase inhibitory activity
AU2005311714B2 (en) * 2004-12-03 2010-09-30 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US7250421B2 (en) * 2005-01-31 2007-07-31 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
US20080280849A1 (en) * 2005-06-01 2008-11-13 Herve Leh Synergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents
WO2007136714A2 (en) * 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
CA2657034A1 (en) 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Pyridinone diketo acids: inhibitors of hiv replication in combination therapy
WO2008041882A1 (fr) * 2006-10-03 2008-04-10 Viktor Veniaminovich Tets Procédé pour agir sur les virus au moyen d'une substance à base de 2,8-dithioxo-1h- pyrano[2,3-d;6,5-d'] dipyrimidine et de leurs analogues 10-aza (et variantes)
US8993542B2 (en) 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
WO2010047774A2 (en) * 2008-10-20 2010-04-29 The Texas A & M University System Inhibitors of mycobacterium tuberculosis malate synthase, methods of marking and uses thereof
US8703801B2 (en) 2009-12-07 2014-04-22 University Of Georgia Research Foundation, Inc. Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
CN101928258B (zh) * 2010-08-18 2014-10-29 杭州民生药业有限公司 1-(2-取代苯胺基-4-甲基-噻唑-5)-3-取代苯基-丙烯酮衍生物、制备方法及其制药用途
DK2691530T3 (en) 2011-06-10 2018-05-22 Univ Oregon Health & Science CMV GLYCOPROTEIN AND RECOMBINANT VECTORS
WO2014026033A1 (en) * 2012-08-08 2014-02-13 University Of Florida Research Foundation, Inc. Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats
MX357940B (es) 2012-12-21 2018-07-31 Gilead Sciences Inc Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico.
NO2865735T3 (id) 2013-07-12 2018-07-21
SI3252058T1 (sl) 2013-07-12 2021-03-31 Gilead Sciences, Inc. Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje okužb s HIV
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (id) 2014-06-20 2018-06-23
TWI738321B (zh) 2014-12-23 2021-09-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
EP3736274A1 (en) 2015-04-02 2020-11-11 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
CN106905244B (zh) * 2017-02-27 2019-08-16 武汉工程大学 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法
KR20220100607A (ko) * 2019-10-28 2022-07-15 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 5원 헤테로사이클릭 옥소카르복실산 화합물 및 이의 의약 용도
CN111943899B (zh) * 2020-09-08 2023-04-21 河北凯诺中星科技有限公司 一种5-甲酸乙酯四氮唑的合成方法
CN113683574B (zh) * 2021-09-06 2023-11-17 上海晋鲁医药科技有限公司 一种合成1-甲基-1h-1,2,4-三唑-3-甲酸甲酯的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899508A (en) 1974-04-12 1975-08-12 Lilly Co Eli 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof
US3931247A (en) * 1974-12-11 1976-01-06 Morton-Norwich Products, Inc. 5-(Substituted)phenylfurfuryl alcohols
JPS5811878B2 (ja) * 1974-12-19 1983-03-04 大正製薬株式会社 フロ （ ３ ２−ｂ ） インド−ルルイノ セイホウ
JPS56100784A (en) 1980-01-16 1981-08-12 Yoshitomi Pharmaceut Ind Ltd Indolizine derivative
US4273776A (en) 1980-01-30 1981-06-16 E. R. Squibb & Sons, Inc. Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones
US4423063A (en) 1980-12-29 1983-12-27 Merck & Co., Inc. 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis
US4336397A (en) 1980-12-29 1982-06-22 Merck & Co., Inc. 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
US4332735A (en) * 1981-07-06 1982-06-01 Morton-Norwich Products, Inc. Antifungal compound
US4637829A (en) * 1984-04-27 1987-01-20 Ciba-Geigy Corporation Sulfonylureas
JPS61134346A (ja) 1984-12-03 1986-06-21 Shionogi & Co Ltd ４−オキソカルボン酸誘導体および抗潰瘍剤
CA1334975C (en) * 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
JPH0238403A (ja) 1988-07-28 1990-02-07 Canon Inc 光重合性組成物および記録媒体
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
TW224974B (id) 1991-07-02 1994-06-11 Hoffmann La Roche
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
JP2000510481A (ja) 1997-04-04 2000-08-15 ファイザー・プロダクツ・インク ニコチンアミド誘導体
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
PL343249A1 (en) 1998-03-26 2001-07-30 Shionogi & Co Indole derivatives with antiviral activity
WO1999048371A1 (en) 1998-03-27 1999-09-30 The Regents Of The University Of California Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors
EP1082121A4 (en) * 1998-06-03 2003-02-05 Merck & Co Inc INTEGRASE HIV INHIBITORS
WO1999062513A1 (en) * 1998-06-03 1999-12-09 Merck & Co., Inc. Hiv integrase inhibitors
EP1086091A4 (en) 1998-06-03 2001-10-10 Merck & Co Inc HIV INTEGRASE INHIBITORS
EP1196384A4 (en) 1999-06-25 2002-10-23 Merck & Co Inc 1- (AROMATIC OR HETEROAROMATICALLY SUBSTITUTED) -3- (HETEROAROMATICALLY SUBSTITUTED) -1,3-PROPANDIONS AND THEIR APPLICATIONS

Also Published As

Publication number Publication date
RU2225860C2 (ru) 2004-03-20
RU2001120016A (ru) 2003-12-10
EP1142872A4 (en) 2002-04-17
CN1335834A (zh) 2002-02-13
JP3929244B2 (ja) 2007-06-13
CA2353961A1 (en) 2000-07-06
HUP0201472A3 (en) 2006-03-28
ATE411286T1 (de) 2008-10-15
NO20013179L (no) 2001-08-27
US7098201B2 (en) 2006-08-29
DE69939749D1 (de) 2008-11-27
US20040002485A1 (en) 2004-01-01
EP1142872A1 (en) 2001-10-10
AP2001002169A0 (en) 2001-06-30
IL143958A0 (en) 2002-04-21
HK1042701A1 (zh) 2002-08-23
HUP0201472A2 (hu) 2003-10-28
TR200101886T2 (tr) 2001-12-21
WO2000039086A1 (fr) 2000-07-06
US6620841B1 (en) 2003-09-16
PL348596A1 (en) 2002-06-03
NZ512184A (en) 2003-08-29
AU763040B2 (en) 2003-07-10
BR9916583A (pt) 2001-09-25
EP1142872B1 (en) 2008-10-15
CN1178913C (zh) 2004-12-08
NO20013179D0 (no) 2001-06-22
CZ20012160A3 (cs) 2001-10-17
AU1797900A (en) 2000-07-31
US6645956B1 (en) 2003-11-11
KR20010089708A (ko) 2001-10-08

Similar Documents

Publication Publication Date Title
ID29027A (id) Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv
ID28376A (id) Pirimidina yang menghambat replikasi hiv
IS6164A (is) Málmpróteasa latar
DE60039829D1 (de) Pulversprühpistole
DE10197409A5 (de) Verringerung der gegenseitigen Störung von drahtlosen Systemen
SG75996A1 (en) Patterned laser zone texture
ATE423776T1 (de) Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
DE60006227D1 (de) Antimikrobielle gegenstände
DE60224568D1 (de) Nach dem hot-melt-verfahren arbeitende tinten
PL370664A1 (en) Hiv integrase inhibitors
AU6989501A (en) Hiv integrase inhibitors
NO20010873D0 (no) Mikropartikkel-blanding
PL351617A1 (en) Substituted benzoylisoxazoles and the use thereof as herbicides
ID30023A (id) Kombinasi senyawa aktif fungisida
IT1314012B1 (it) Apparecchiatura per la finitura di superfici metalliche.
PT1164877E (pt) Equipamento de pulverizacao
NO20020690D0 (no) Spröyteinnretning
HK1048315A1 (zh) 取代的雜芳基氧基乙酰苯胺類化合物及其作為除草劑的應用
ID27234A (id) Turunan-turunan triazol yang mempunyai aktivitas anti-jamur
ES1041767Y (es) Perfil metalico para estructuras y similares.
ES1042893Y (es) Dispositivo para prevencion de caidas.
GB9814925D0 (en) HIV integrase inhibitors
ES1039321Y (es) Tripode para formacion de mesas y similares.
ITSP990009U4 (it) Congegno di sollevo/sollievo lungodegenti.
AU2002321974A1 (en) Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents