ID29027A - Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv - Google Patents
Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hivInfo
- Publication number
- ID29027A ID29027A IDW00200101355A ID20011355A ID29027A ID 29027 A ID29027 A ID 29027A ID W00200101355 A IDW00200101355 A ID W00200101355A ID 20011355 A ID20011355 A ID 20011355A ID 29027 A ID29027 A ID 29027A
- Authority
- ID
- Indonesia
- Prior art keywords
- heteroaromatic
- damages
- hazard
- against hiv
- activities against
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP37127098 | 1998-12-25 | ||
| JP24747999 | 1999-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID29027A true ID29027A (id) | 2001-07-26 |
Family
ID=26538287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW00200101355A ID29027A (id) | 1998-12-25 | 1999-12-17 | Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6620841B1 (de) |
| EP (1) | EP1142872B1 (de) |
| JP (1) | JP3929244B2 (de) |
| KR (1) | KR20010089708A (de) |
| CN (1) | CN1178913C (de) |
| AP (1) | AP2001002169A0 (de) |
| AT (1) | ATE411286T1 (de) |
| AU (1) | AU763040B2 (de) |
| BR (1) | BR9916583A (de) |
| CA (1) | CA2353961A1 (de) |
| CZ (1) | CZ20012160A3 (de) |
| DE (1) | DE69939749D1 (de) |
| HK (1) | HK1042701A1 (de) |
| HU (1) | HUP0201472A3 (de) |
| ID (1) | ID29027A (de) |
| IL (1) | IL143958A0 (de) |
| NO (1) | NO20013179L (de) |
| NZ (1) | NZ512184A (de) |
| PL (1) | PL348596A1 (de) |
| RU (1) | RU2225860C2 (de) |
| TR (1) | TR200101886T2 (de) |
| WO (1) | WO2000039086A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306891B1 (en) | 1998-06-03 | 2001-10-23 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6262055B1 (en) | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6380249B1 (en) | 1998-06-03 | 2002-04-30 | Merck & Co., Inc. | HIV integrase inhibitors |
| ES2244204T3 (es) | 1998-07-27 | 2005-12-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Derivados de dicetoacidos como inhibidores de polimerasas. |
| GB9816358D0 (en) * | 1998-07-27 | 1998-09-23 | Angeletti P Ist Richerche Bio | Enzyme inhibitors |
| CA2376043A1 (en) * | 1999-06-02 | 2000-12-14 | Shionogi & Co., Ltd. | Novel processes for the preparation of substituted propenone derivatives |
| CA2370500A1 (en) * | 1999-06-25 | 2001-01-04 | Lekhanh O. Tran | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
| IL153363A0 (en) * | 2000-06-13 | 2003-07-06 | Shionogi & Co | Pharmaceutical compositions containing propenone derivatives |
| EP1297834A4 (de) * | 2000-06-14 | 2007-05-09 | Shionogi & Co | Enzyminhibitor mit zwei divalenten metallionen als aktiven zentren |
| WO2002038771A1 (fr) * | 2000-11-09 | 2002-05-16 | Shionogi & Co., Ltd. | Integrases du hiv tolerantes aux medicaments |
| KR100977701B1 (ko) * | 2001-08-10 | 2010-08-24 | 시오노기세이야쿠가부시키가이샤 | 항바이러스제 |
| CN1700918B (zh) * | 2001-10-26 | 2011-06-08 | P·安杰莱蒂分子生物学研究所 | 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂 |
| TW200407132A (en) * | 2001-11-15 | 2004-05-16 | Shionogi & Co | Process for producing 1-H-1,2,4-triazole-3-carboxylic acid ester |
| WO2003047564A1 (fr) * | 2001-12-05 | 2003-06-12 | Shionogi & Co., Ltd. | Dérivé ayant une activité d'inhibition de l'intégrase du vih |
| DE60322920D1 (de) | 2002-08-13 | 2008-09-25 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung |
| WO2004035577A2 (en) | 2002-10-16 | 2004-04-29 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| CN1569803B (zh) * | 2003-07-16 | 2011-04-13 | 中国科学院上海药物研究所 | 芳基β－二酮酸的新制备方法 |
| EP1715855A4 (de) * | 2004-01-29 | 2010-06-16 | Elixir Pharmaceuticals Inc | Antivirale therapeutika |
| JP4952943B2 (ja) * | 2004-08-25 | 2012-06-13 | アーディア・バイオサイエンシーズ・インコーポレイテッド | ＨＩＶ逆転写酵素のインヒビターとしてのＳ−トリアゾリルα−メルカプトアセトアニリド |
| US7550463B2 (en) | 2004-09-15 | 2009-06-23 | Shionogi & Co., Ltd. | Carbamoylpyridone derivatives having inhibitory activity against HIV integrase |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| AU2005311714B2 (en) * | 2004-12-03 | 2010-09-30 | Merck Sharp & Dohme Corp. | Pharmaceutical composition containing an anti-nucleating agent |
| US7250421B2 (en) * | 2005-01-31 | 2007-07-31 | University Of Georgia Research Foundation, Inc. | Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase |
| WO2006129134A1 (en) * | 2005-06-01 | 2006-12-07 | Bioalliance Pharma | Synergic combinations comprising a styrylquinoline compound and other hiv infection therapeutic agents |
| JP2009537546A (ja) * | 2006-05-16 | 2009-10-29 | ギリアード サイエンシーズ， インコーポレイテッド | インテグラーゼ阻害剤 |
| AU2007275805A1 (en) * | 2006-07-19 | 2008-01-24 | University Of Georgia Research Foundation, Inc. | Pyridinone diketo acids: Inhibitors of HIV replication in combination therapy |
| WO2008041882A1 (fr) * | 2006-10-03 | 2008-04-10 | Viktor Veniaminovich Tets | Procédé pour agir sur les virus au moyen d'une substance à base de 2,8-dithioxo-1h- pyrano[2,3-d;6,5-d'] dipyrimidine et de leurs analogues 10-aza (et variantes) |
| MX2010008148A (es) | 2008-01-25 | 2010-10-20 | Chimerix Inc | Métodos de tratamiento de infecciones virales. |
| US8664255B2 (en) | 2008-10-20 | 2014-03-04 | The Texas A&M University System | Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof |
| MX2012006485A (es) | 2009-12-07 | 2012-08-23 | Univ Georgia | Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas. |
| EP3216789A1 (de) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Verfahren zur behandlung von vireninfektionen |
| WO2011119920A2 (en) | 2010-03-25 | 2011-09-29 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| CN101928258B (zh) * | 2010-08-18 | 2014-10-29 | 杭州民生药业有限公司 | 1-(2-取代苯胺基-4-甲基-噻唑-5)-3-取代苯基-丙烯酮衍生物、制备方法及其制药用途 |
| HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
| WO2014026033A1 (en) | 2012-08-08 | 2014-02-13 | University Of Florida Research Foundation, Inc. | Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats |
| KR102040007B1 (ko) | 2012-12-21 | 2019-11-05 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
| ES2645192T3 (es) | 2013-07-12 | 2017-12-04 | Gilead Sciences, Inc. | Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH |
| NO2865735T3 (de) | 2013-07-12 | 2018-07-21 | ||
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (de) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| EP3736274A1 (de) | 2015-04-02 | 2020-11-11 | Gilead Sciences, Inc. | Polycyclische carbamoylpyridonverbindungen und deren pharmazeutische verwendung |
| CN106905244B (zh) * | 2017-02-27 | 2019-08-16 | 武汉工程大学 | 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法 |
| AU2020373913B2 (en) * | 2019-10-28 | 2024-04-18 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof |
| CN111943899B (zh) * | 2020-09-08 | 2023-04-21 | 河北凯诺中星科技有限公司 | 一种5-甲酸乙酯四氮唑的合成方法 |
| CN113683574B (zh) * | 2021-09-06 | 2023-11-17 | 上海晋鲁医药科技有限公司 | 一种合成1-甲基-1h-1,2,4-三唑-3-甲酸甲酯的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899508A (en) | 1974-04-12 | 1975-08-12 | Lilly Co Eli | 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof |
| US3931247A (en) | 1974-12-11 | 1976-01-06 | Morton-Norwich Products, Inc. | 5-(Substituted)phenylfurfuryl alcohols |
| JPS5811878B2 (ja) | 1974-12-19 | 1983-03-04 | 大正製薬株式会社 | フロ （ ３ ２−ｂ ） インド−ルルイノ セイホウ |
| JPS56100784A (en) | 1980-01-16 | 1981-08-12 | Yoshitomi Pharmaceut Ind Ltd | Indolizine derivative |
| US4273776A (en) * | 1980-01-30 | 1981-06-16 | E. R. Squibb & Sons, Inc. | Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones |
| US4423063A (en) | 1980-12-29 | 1983-12-27 | Merck & Co., Inc. | 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis |
| US4336397A (en) | 1980-12-29 | 1982-06-22 | Merck & Co., Inc. | 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis |
| US4332735A (en) | 1981-07-06 | 1982-06-01 | Morton-Norwich Products, Inc. | Antifungal compound |
| US4637829A (en) | 1984-04-27 | 1987-01-20 | Ciba-Geigy Corporation | Sulfonylureas |
| JPS61134346A (ja) | 1984-12-03 | 1986-06-21 | Shionogi & Co Ltd | ４−オキソカルボン酸誘導体および抗潰瘍剤 |
| CA1334975C (en) | 1987-11-13 | 1995-03-28 | James H. Holms | Furan and pyrrole containing lipoxygenase inhibiting compounds |
| JPH0238403A (ja) | 1988-07-28 | 1990-02-07 | Canon Inc | 光重合性組成物および記録媒体 |
| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| TW224974B (de) | 1991-07-02 | 1994-06-11 | Hoffmann La Roche | |
| EP0658559A1 (de) * | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| US5693804A (en) * | 1994-11-17 | 1997-12-02 | Molecular Geriatrics Corporation | Substituted 1-aryl-3-piperazin-1'-yl propanones |
| TR199902432T2 (xx) | 1997-04-04 | 2000-01-21 | Prizer Products Inc. | Nikotinamid t�revleri. |
| IL122591A0 (en) | 1997-12-14 | 1998-06-15 | Arad Dorit | Pharmaceutical compositions comprising cystein protease inhibitors |
| RU2217421C2 (ru) | 1998-03-26 | 2003-11-27 | Шионоги & Ко., Лтд. | Производные индола, обладающие антивирусной активностью |
| EP1063888A1 (de) | 1998-03-27 | 2001-01-03 | The Regents of the University of California | Neue hiv integrase inhibitoren und auf integrase inhibitoren einschliessende medikamentzusammensetzungen basierte hiv-therapie |
| CA2333771A1 (en) | 1998-06-03 | 1999-12-09 | Mark W. Embrey | Hiv integrase inhibitors |
| JP2002516858A (ja) | 1998-06-03 | 2002-06-11 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬 |
| AU4225499A (en) | 1998-06-03 | 1999-12-20 | Merck & Co., Inc. | Hiv integrase inhibitors |
| CA2370500A1 (en) | 1999-06-25 | 2001-01-04 | Lekhanh O. Tran | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
-
1999
- 1999-12-17 JP JP2000590998A patent/JP3929244B2/ja not_active Expired - Fee Related
- 1999-12-17 AT AT99961299T patent/ATE411286T1/de not_active IP Right Cessation
- 1999-12-17 EP EP99961299A patent/EP1142872B1/de not_active Expired - Lifetime
- 1999-12-17 AU AU17979/00A patent/AU763040B2/en not_active Ceased
- 1999-12-17 US US09/857,632 patent/US6620841B1/en not_active Expired - Fee Related
- 1999-12-17 KR KR1020017008150A patent/KR20010089708A/ko not_active Application Discontinuation
- 1999-12-17 DE DE69939749T patent/DE69939749D1/de not_active Expired - Lifetime
- 1999-12-17 TR TR2001/01886T patent/TR200101886T2/xx unknown
- 1999-12-17 CZ CZ20012160A patent/CZ20012160A3/cs unknown
- 1999-12-17 BR BR9916583-0A patent/BR9916583A/pt not_active IP Right Cessation
- 1999-12-17 ID IDW00200101355A patent/ID29027A/id unknown
- 1999-12-17 CA CA002353961A patent/CA2353961A1/en not_active Abandoned
- 1999-12-17 NZ NZ512184A patent/NZ512184A/xx unknown
- 1999-12-17 CN CNB99816285XA patent/CN1178913C/zh not_active Expired - Fee Related
- 1999-12-17 HU HU0201472A patent/HUP0201472A3/hu unknown
- 1999-12-17 PL PL99348596A patent/PL348596A1/xx not_active Application Discontinuation
- 1999-12-17 WO PCT/JP1999/007101 patent/WO2000039086A1/ja not_active Application Discontinuation
- 1999-12-17 IL IL14395899A patent/IL143958A0/xx unknown
- 1999-12-17 AP APAP/P/2001/002169A patent/AP2001002169A0/en unknown
- 1999-12-17 RU RU2001120016/04A patent/RU2225860C2/ru not_active IP Right Cessation
-
2001
- 2001-06-22 NO NO20013179A patent/NO20013179L/no not_active Application Discontinuation
-
2002
- 2002-06-04 HK HK02104241.7A patent/HK1042701A1/zh unknown
- 2002-11-06 US US10/288,380 patent/US6645956B1/en not_active Expired - Fee Related
-
2003
- 2003-06-18 US US10/463,816 patent/US7098201B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1142872B1 (de) | 2008-10-15 |
| RU2001120016A (ru) | 2003-12-10 |
| EP1142872A1 (de) | 2001-10-10 |
| RU2225860C2 (ru) | 2004-03-20 |
| TR200101886T2 (tr) | 2001-12-21 |
| IL143958A0 (en) | 2002-04-21 |
| US20040002485A1 (en) | 2004-01-01 |
| CN1335834A (zh) | 2002-02-13 |
| US6645956B1 (en) | 2003-11-11 |
| EP1142872A4 (de) | 2002-04-17 |
| US6620841B1 (en) | 2003-09-16 |
| CN1178913C (zh) | 2004-12-08 |
| HUP0201472A2 (hu) | 2003-10-28 |
| KR20010089708A (ko) | 2001-10-08 |
| BR9916583A (pt) | 2001-09-25 |
| AU1797900A (en) | 2000-07-31 |
| NO20013179D0 (no) | 2001-06-22 |
| NO20013179L (no) | 2001-08-27 |
| HUP0201472A3 (en) | 2006-03-28 |
| US7098201B2 (en) | 2006-08-29 |
| CA2353961A1 (en) | 2000-07-06 |
| AU763040B2 (en) | 2003-07-10 |
| DE69939749D1 (de) | 2008-11-27 |
| HK1042701A1 (zh) | 2002-08-23 |
| JP3929244B2 (ja) | 2007-06-13 |
| NZ512184A (en) | 2003-08-29 |
| WO2000039086A1 (fr) | 2000-07-06 |
| AP2001002169A0 (en) | 2001-06-30 |
| CZ20012160A3 (cs) | 2001-10-17 |
| PL348596A1 (en) | 2002-06-03 |
| ATE411286T1 (de) | 2008-10-15 |
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