IL143958A0 - Heteroaromatic derivatives having an inhibitory activity against hiv integrase - Google Patents

Heteroaromatic derivatives having an inhibitory activity against hiv integrase

Info

Publication number
IL143958A0
IL143958A0 IL14395899A IL14395899A IL143958A0 IL 143958 A0 IL143958 A0 IL 143958A0 IL 14395899 A IL14395899 A IL 14395899A IL 14395899 A IL14395899 A IL 14395899A IL 143958 A0 IL143958 A0 IL 143958A0
Authority
IL
Israel
Prior art keywords
inhibitory activity
activity against
against hiv
hiv integrase
heteroaromatic derivatives
Prior art date
Application number
IL14395899A
Other languages
English (en)
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of IL143958A0 publication Critical patent/IL143958A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
IL14395899A 1998-12-25 1999-12-17 Heteroaromatic derivatives having an inhibitory activity against hiv integrase IL143958A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP37127098 1998-12-25
JP24747999 1999-09-01
PCT/JP1999/007101 WO2000039086A1 (fr) 1998-12-25 1999-12-17 Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih

Publications (1)

Publication Number Publication Date
IL143958A0 true IL143958A0 (en) 2002-04-21

Family

ID=26538287

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14395899A IL143958A0 (en) 1998-12-25 1999-12-17 Heteroaromatic derivatives having an inhibitory activity against hiv integrase

Country Status (22)

Country Link
US (3) US6620841B1 (de)
EP (1) EP1142872B1 (de)
JP (1) JP3929244B2 (de)
KR (1) KR20010089708A (de)
CN (1) CN1178913C (de)
AP (1) AP2001002169A0 (de)
AT (1) ATE411286T1 (de)
AU (1) AU763040B2 (de)
BR (1) BR9916583A (de)
CA (1) CA2353961A1 (de)
CZ (1) CZ20012160A3 (de)
DE (1) DE69939749D1 (de)
HK (1) HK1042701A1 (de)
HU (1) HUP0201472A3 (de)
ID (1) ID29027A (de)
IL (1) IL143958A0 (de)
NO (1) NO20013179L (de)
NZ (1) NZ512184A (de)
PL (1) PL348596A1 (de)
RU (1) RU2225860C2 (de)
TR (1) TR200101886T2 (de)
WO (1) WO2000039086A1 (de)

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CA2370500A1 (en) * 1999-06-25 2001-01-04 Lekhanh O. Tran 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
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WO2003047564A1 (fr) * 2001-12-05 2003-06-12 Shionogi & Co., Ltd. Dérivé ayant une activité d'inhibition de l'intégrase du vih
DE60322920D1 (de) 2002-08-13 2008-09-25 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung
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CN1569803B (zh) * 2003-07-16 2011-04-13 中国科学院上海药物研究所 芳基β－二酮酸的新制备方法
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TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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TWI738321B (zh) 2014-12-23 2021-09-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
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CN106905244B (zh) * 2017-02-27 2019-08-16 武汉工程大学 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法
AU2020373913B2 (en) * 2019-10-28 2024-04-18 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof
CN111943899B (zh) * 2020-09-08 2023-04-21 河北凯诺中星科技有限公司 一种5-甲酸乙酯四氮唑的合成方法
CN113683574B (zh) * 2021-09-06 2023-11-17 上海晋鲁医药科技有限公司 一种合成1-甲基-1h-1,2,4-三唑-3-甲酸甲酯的方法

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Also Published As

Publication number Publication date
EP1142872B1 (de) 2008-10-15
RU2001120016A (ru) 2003-12-10
EP1142872A1 (de) 2001-10-10
RU2225860C2 (ru) 2004-03-20
ID29027A (id) 2001-07-26
TR200101886T2 (tr) 2001-12-21
US20040002485A1 (en) 2004-01-01
CN1335834A (zh) 2002-02-13
US6645956B1 (en) 2003-11-11
EP1142872A4 (de) 2002-04-17
US6620841B1 (en) 2003-09-16
CN1178913C (zh) 2004-12-08
HUP0201472A2 (hu) 2003-10-28
KR20010089708A (ko) 2001-10-08
BR9916583A (pt) 2001-09-25
AU1797900A (en) 2000-07-31
NO20013179D0 (no) 2001-06-22
NO20013179L (no) 2001-08-27
HUP0201472A3 (en) 2006-03-28
US7098201B2 (en) 2006-08-29
CA2353961A1 (en) 2000-07-06
AU763040B2 (en) 2003-07-10
DE69939749D1 (de) 2008-11-27
HK1042701A1 (zh) 2002-08-23
JP3929244B2 (ja) 2007-06-13
NZ512184A (en) 2003-08-29
WO2000039086A1 (fr) 2000-07-06
AP2001002169A0 (en) 2001-06-30
CZ20012160A3 (cs) 2001-10-17
PL348596A1 (en) 2002-06-03
ATE411286T1 (de) 2008-10-15

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