DK2266958T1 - Antiviralt middel - Google Patents

Antiviralt middel Download PDF

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Publication number
DK2266958T1
DK2266958T1 DK10178132.6T DK10178132T DK2266958T1 DK 2266958 T1 DK2266958 T1 DK 2266958T1 DK 10178132 T DK10178132 T DK 10178132T DK 2266958 T1 DK2266958 T1 DK 2266958T1
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DK
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Prior art keywords
ring
optionally substituted
aryl
bond
alkyl
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DK10178132.6T
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English (en)
Inventor
Ryuichi Kiyama
Yasuhiko Kanda
Yukio Tada
Toshio Fujishita
Takashi Kawasuji
Shozo Takechi
Masahiro Fuji
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Shionogi & Co
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27347328&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2266958(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of DK2266958T1 publication Critical patent/DK2266958T1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/42—Oxazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Claims (3)

  1. PROVISORISKE KRAV
    1. Farmaceutisk sammensætning indeholdende som aktiv bestanddel en forbindelse med formel (I)
    (hvor Rc og RD, når taget sammen med nabocarbonatomerne, danner en 5- til 6-leddet ring der kan indeholde (a) heteroatom(er) af N og/eller O og kan kondenseres med en benzenring, Y er hydroxy; Z er O; RA er en gruppe vist med
    (hvor ring C er en N-indeholdende aromatisk heterocykel, hvor mindst ét naboliggende atom til det atom ved bindings-positionen er et ikke-substitueret N-atom; den punkterede linje viser tilstedeværelsen eller fraværet afen binding.) eller ved
    (hvor X er O; RB er en substituent valgt fra amino, aryl, eller heteroaryl); mindst én af ringen dannet ved Rc og RD, ring C eller RB er substitueret med en gruppe -Z1-Z2-Z3-R1 (hvor, Z1 og Z3 er hver uafhængigt en binding, alkylen eller alkenylen; Z2 er en binding, alkylen, alkenylen, -CH(OH)-, -S-, -SO-, -SO2-, -SO2NR2-, -NR2S02, -O-, -NR2-, -NR2CO-, -CONR2-, -0(=0)-0-, -0-0(=0) eller - C0-; R2 er hydrogen, alkyl, alkenyl, aryl eller heteroaryl; R1 er eventuelt substitueret aryl, eventuelt substitueret heteroaryl, eller eventuelt substitueret cycloalkyl); hvor R1 er eventuelt substutueret med én eller flere substituenter valgt fra C1-C6 alkyl, C1-C6 haloalkyl, halogen eller Ci-C6alkoxy; ringen dannet ved Rc og RD, ring C eller RB er eventuelt substitueret med en ikke-interfererende substituent valgt fra hydrogen, halogen, alkyl, aralkyl, cycloalkyl, aryl, alkoxy, alkoxyalkyl, amino, hydroxyalkyl, alkenyl, alkoxycarbonylalkyl, heteroarylalkyl eller hydroxy ved en hvilken som helst position udover den hvor gruppen af -Z1-Z2-Z3-R1 (hvor, Z1, Z2, Z3 og R1 er den samme som ovenfor) placeret; eller et farmaceutisk acceptabelt salt eller solvat deraf, til anvendelse som et anti-HIV-middel.
  2. 2. Farmaceutisk sammensætning ifølge krav 1 i kombination med andre HIV-midler med en forskellig virkningsmekanisme.
  3. 3. Farmaceutisk sammensætning ifølge krav 1 i kombination med en revers transkriptaseinhibitor og/eller en proteaseinhibitor.
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