IL127177A - ANTIPYSYCHOTIC 5-(1, 3, 4, 4a, 5, 9b-HEXAHYDRO-PYRIDO (3, 4-b) INDOL-2-YLALKYL) PYRIMIDIN-4-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

ANTIPYSYCHOTIC 5-(1, 3, 4, 4a, 5, 9b-HEXAHYDRO-PYRIDO (3, 4-b) INDOL-2-YLALKYL) PYRIMIDIN-4-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IL127177A
IL127177A IL12717797A IL12717797A IL127177A IL 127177 A IL127177 A IL 127177A IL 12717797 A IL12717797 A IL 12717797A IL 12717797 A IL12717797 A IL 12717797A IL 127177 A IL127177 A IL 127177A
Authority
IL
Israel
Prior art keywords
6alkyl
hydrogen
pct
preparation
compositions containing
Prior art date
Application number
IL12717797A
Other languages
English (en)
Other versions
IL127177A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL127177A0 publication Critical patent/IL127177A0/xx
Publication of IL127177A publication Critical patent/IL127177A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
IL12717797A 1996-05-23 1997-05-15 ANTIPYSYCHOTIC 5-(1, 3, 4, 4a, 5, 9b-HEXAHYDRO-PYRIDO (3, 4-b) INDOL-2-YLALKYL) PYRIMIDIN-4-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL127177A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201450 1996-05-23
PCT/EP1997/002710 WO1997044040A1 (en) 1996-05-23 1997-05-15 Hexahydro-pyrido(4,3-b)indole derivatives as antipsychotic drugs

Publications (2)

Publication Number Publication Date
IL127177A0 IL127177A0 (en) 1999-09-22
IL127177A true IL127177A (en) 2003-10-31

Family

ID=8224021

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12717797A IL127177A (en) 1996-05-23 1997-05-15 ANTIPYSYCHOTIC 5-(1, 3, 4, 4a, 5, 9b-HEXAHYDRO-PYRIDO (3, 4-b) INDOL-2-YLALKYL) PYRIMIDIN-4-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (22)

Country Link
US (1) US6057325A (xx)
EP (1) EP0902684B1 (xx)
JP (1) JP2000510860A (xx)
CN (1) CN1149996C (xx)
AT (1) ATE236636T1 (xx)
AU (1) AU714113B2 (xx)
CA (1) CA2254755C (xx)
CY (1) CY2381B1 (xx)
CZ (1) CZ287961B6 (xx)
DE (1) DE69720715T2 (xx)
DK (1) DK0902684T3 (xx)
ES (1) ES2196332T3 (xx)
IL (1) IL127177A (xx)
MY (1) MY125562A (xx)
NO (1) NO311724B1 (xx)
NZ (1) NZ332310A (xx)
PL (1) PL187345B1 (xx)
PT (1) PT902684E (xx)
SI (1) SI0902684T1 (xx)
TW (1) TW470745B (xx)
WO (1) WO1997044040A1 (xx)
ZA (1) ZA974470B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1136493A1 (en) * 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
JP2005526691A (ja) * 2001-08-08 2005-09-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療剤１Ｈ−ピリド［４，３−ｂ］インドール
JP4486505B2 (ja) * 2002-12-19 2010-06-23 ブリストル−マイヤーズ スクイブ カンパニー セロトニン・レセプタ作用薬および拮抗薬としての置換トリ環式ガンマ−カルボリン化合物
EP1905774B1 (en) * 2003-09-17 2013-02-20 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as serotonin receptor modulators
CA2782783C (en) * 2003-09-17 2018-03-27 Janssen Pharmaceutical, N.V. Fused heterocyclic compounds
ATE420881T1 (de) * 2003-09-17 2009-01-15 Janssen Pharmaceutica Nv Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
KR101168611B1 (ko) 2003-09-17 2012-08-03 얀센 파마슈티카 엔.브이. 세로토닌 수용체 조절자로서의 융합된 헤테로사이클릭 화합물
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
BRPI0815850A2 (pt) * 2007-08-01 2014-10-07 Medivation Neurology Inc "método para tratar, retardar a progressão, prevenir ou atrasar o desenvolvimento de esquizofrenia em um individuo, composiçã farmaceuticamente aceitável, kit e método para reforçar uma resposta de um individuo a um antipsicótico"
CA2742320A1 (en) 2008-10-31 2010-05-06 Medivation Technologies, Inc. Pyrido[4,3-b]indoles containing rigid moieties
JP5551708B2 (ja) 2008-10-31 2014-07-16 メディベイション テクノロジーズ， インコーポレイテッド アゼピノ［４，５−ｂ］インドール化合物およびその使用方法
CA2827642A1 (en) 2011-02-18 2012-11-15 Medivation Technologies, Inc. Compounds and methods of treating diabetes
WO2014031165A1 (en) * 2012-08-22 2014-02-27 Medivation Technologies, Inc. Compounds and methods of treating diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
US4337250A (en) * 1979-07-30 1982-06-29 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents

Also Published As

Publication number Publication date
PL330079A1 (en) 1999-04-26
EP0902684A1 (en) 1999-03-24
NO985389D0 (no) 1998-11-19
JP2000510860A (ja) 2000-08-22
NZ332310A (en) 1999-08-30
PL187345B1 (pl) 2004-06-30
AU2961697A (en) 1997-12-09
CZ287961B6 (cs) 2001-03-14
CY2381B1 (en) 2004-06-04
CZ377498A3 (cs) 1999-02-17
ES2196332T3 (es) 2003-12-16
IL127177A0 (en) 1999-09-22
WO1997044040A1 (en) 1997-11-27
CA2254755A1 (en) 1997-11-27
NO985389L (no) 1999-01-20
ATE236636T1 (de) 2003-04-15
DK0902684T3 (da) 2004-03-29
DE69720715D1 (en) 2003-05-15
ZA974470B (en) 1998-11-23
US6057325A (en) 2000-05-02
AU714113B2 (en) 1999-12-16
DE69720715T2 (de) 2004-03-11
TW470745B (en) 2002-01-01
SI0902684T1 (en) 2003-10-31
CA2254755C (en) 2007-01-16
MY125562A (en) 2006-08-30
NO311724B1 (no) 2002-01-14
PT902684E (pt) 2003-08-29
EP0902684B1 (en) 2003-04-09
CN1149996C (zh) 2004-05-19
CN1219875A (zh) 1999-06-16

Similar Documents

Publication Publication Date Title
AP1468A (en) Hiv inhibiting pyrimidine derivatives.
BG104716A (en) Trisubstituted 1,3,5-triazine derivatives for the treatment of hiv infection
ATE184281T1 (de) 9-hydroxy-pyrido (1,2-a> pyrimidin-4-on-ether- derivate
IL123655A (en) Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them
IL127177A (en) ANTIPYSYCHOTIC 5-(1, 3, 4, 4a, 5, 9b-HEXAHYDRO-PYRIDO (3, 4-b) INDOL-2-YLALKYL) PYRIMIDIN-4-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ZA937241B (en) 5h, 10h-imidazo(,2-a) indeno(1,2-e)pyrazin-4-one derivatives their preparation and medicinal products containing them
MY130950A (en) 4-(1h-indol-1-yl)-1-piperidinyl derivatives
AU2896197A (en) Adenosine derivatives
IL113254A0 (en) Substituted azolone derivatives their preparation and pharmaceutical compositions containing them
NO973340L (no) Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for behandling eller profylakse av fedme
HK1032404A1 (en) 2,4,4-Trisubstituted-1,3-dioxolane antifungals.
NO973242L (no) Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for behandling eller profylakse av idiopatisk eller fysiologisk gynekomasti
IL133653A (en) Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives, their preparation and pharmaceutical compositions comprising them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees