DK0902684T3 - Hexahydro-pyrido (4,3-B) indolderivater som antipsykotiske lægemidler - Google Patents

Hexahydro-pyrido (4,3-B) indolderivater som antipsykotiske lægemidler

Info

Publication number
DK0902684T3
DK0902684T3 DK97924014T DK97924014T DK0902684T3 DK 0902684 T3 DK0902684 T3 DK 0902684T3 DK 97924014 T DK97924014 T DK 97924014T DK 97924014 T DK97924014 T DK 97924014T DK 0902684 T3 DK0902684 T3 DK 0902684T3
Authority
DK
Denmark
Prior art keywords
6alkyl
hydrogen
pct
formula
date nov
Prior art date
Application number
DK97924014T
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0902684T3 publication Critical patent/DK0902684T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DK97924014T 1996-05-23 1997-05-15 Hexahydro-pyrido (4,3-B) indolderivater som antipsykotiske lægemidler DK0902684T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201450 1996-05-23
PCT/EP1997/002710 WO1997044040A1 (en) 1996-05-23 1997-05-15 Hexahydro-pyrido(4,3-b)indole derivatives as antipsychotic drugs

Publications (1)

Publication Number Publication Date
DK0902684T3 true DK0902684T3 (da) 2004-03-29

Family

ID=8224021

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97924014T DK0902684T3 (da) 1996-05-23 1997-05-15 Hexahydro-pyrido (4,3-B) indolderivater som antipsykotiske lægemidler

Country Status (22)

Country Link
US (1) US6057325A (da)
EP (1) EP0902684B1 (da)
JP (1) JP2000510860A (da)
CN (1) CN1149996C (da)
AT (1) ATE236636T1 (da)
AU (1) AU714113B2 (da)
CA (1) CA2254755C (da)
CY (1) CY2381B1 (da)
CZ (1) CZ287961B6 (da)
DE (1) DE69720715T2 (da)
DK (1) DK0902684T3 (da)
ES (1) ES2196332T3 (da)
IL (1) IL127177A (da)
MY (1) MY125562A (da)
NO (1) NO311724B1 (da)
NZ (1) NZ332310A (da)
PL (1) PL187345B1 (da)
PT (1) PT902684E (da)
SI (1) SI0902684T1 (da)
TW (1) TW470745B (da)
WO (1) WO1997044040A1 (da)
ZA (1) ZA974470B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1136493A1 (en) * 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
MXPA04001203A (es) * 2001-08-08 2004-05-20 Pharmacia & Upjhon Company 1-h-pirido[4,3-b] indoles terapeuticos.
AU2003303210A1 (en) * 2002-12-19 2004-07-14 Bristol-Myers Squibb Company Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
ATE420881T1 (de) * 2003-09-17 2009-01-15 Janssen Pharmaceutica Nv Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
CN1882590B (zh) * 2003-09-17 2014-03-05 詹森药业有限公司 作为血清素受体调节剂的稠合杂环化合物
EP1905774B1 (en) * 2003-09-17 2013-02-20 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as serotonin receptor modulators
KR101168611B1 (ko) 2003-09-17 2012-08-03 얀센 파마슈티카 엔.브이. 세로토닌 수용체 조절자로서의 융합된 헤테로사이클릭 화합물
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
CA2719824A1 (en) * 2007-08-01 2009-02-05 Medivation Neurology, Inc. Methods and compositions for treating schizophrenia using antipsychotic combination therapy
TWI482773B (zh) 2008-10-31 2015-05-01 Medivation Technologies Inc 氮呯并〔４，５－ｂ〕吲哚及使用方法
AU2009308706C1 (en) * 2008-10-31 2016-01-21 Medivation Technologies, Inc. Pyrido (4,3-b) indoles containing rigid moieties
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法
US20150315188A1 (en) * 2012-08-22 2015-11-05 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
US4337250A (en) * 1979-07-30 1982-06-29 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents

Also Published As

Publication number Publication date
MY125562A (en) 2006-08-30
SI0902684T1 (en) 2003-10-31
WO1997044040A1 (en) 1997-11-27
CN1219875A (zh) 1999-06-16
CZ377498A3 (cs) 1999-02-17
EP0902684A1 (en) 1999-03-24
NZ332310A (en) 1999-08-30
EP0902684B1 (en) 2003-04-09
AU2961697A (en) 1997-12-09
DE69720715D1 (en) 2003-05-15
CA2254755C (en) 2007-01-16
NO985389D0 (no) 1998-11-19
IL127177A0 (en) 1999-09-22
AU714113B2 (en) 1999-12-16
NO985389L (no) 1999-01-20
PL187345B1 (pl) 2004-06-30
ATE236636T1 (de) 2003-04-15
CN1149996C (zh) 2004-05-19
CA2254755A1 (en) 1997-11-27
JP2000510860A (ja) 2000-08-22
TW470745B (en) 2002-01-01
CY2381B1 (en) 2004-06-04
ES2196332T3 (es) 2003-12-16
PL330079A1 (en) 1999-04-26
PT902684E (pt) 2003-08-29
CZ287961B6 (cs) 2001-03-14
IL127177A (en) 2003-10-31
DE69720715T2 (de) 2004-03-11
ZA974470B (en) 1998-11-23
US6057325A (en) 2000-05-02
NO311724B1 (no) 2002-01-14

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