EA200401204A1 - Сульфонилпроизводные в качестве новых ингибиторов гистон-деацетилазы - Google Patents

Сульфонилпроизводные в качестве новых ингибиторов гистон-деацетилазы

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Publication number
EA200401204A1
EA200401204A1 EA200401204A EA200401204A EA200401204A1 EA 200401204 A1 EA200401204 A1 EA 200401204A1 EA 200401204 A EA200401204 A EA 200401204A EA 200401204 A EA200401204 A EA 200401204A EA 200401204 A1 EA200401204 A1 EA 200401204A1
Authority
EA
Eurasian Patent Office
Prior art keywords
histon
new
deacetylase inhibitors
sulphinyl
derivatives
Prior art date
Application number
EA200401204A
Other languages
English (en)
Other versions
EA007099B1 (ru
Inventor
Кристоф Ван Эмелен
Лео Якобус Йозеф Бакс
Свен Францискус Анна Ван Брандт
Патрик Рене Анжибо
Изабелль Ноэлль Констанс Пилатт
Марк Густаф Селин Вердонк
Ханс Луи Йос Де Винтер
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200401204A1 publication Critical patent/EA200401204A1/ru
Publication of EA007099B1 publication Critical patent/EA007099B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

Данное изобретение включает в себя новые соединения формулы (I), где n, m, t, R, R, R, R, R, L, Q, X, Y, Z имеют определенные значения, ингибирующие ферментную активность гистон-деацетилазы; их получение, содержащие их композиции и их применение в качестве лекарственного препарата.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401204A 2002-03-13 2003-03-11 Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы EA007099B1 (ru)

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PCT/EP2003/002517 WO2003076401A1 (en) 2002-03-13 2003-03-11 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase

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US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
DE60320957D1 (en) 2002-03-13 2008-06-26 Janssen Pharmaceutica Nv Sulfonylderivate als histone-deacetylase-inhibitoren
US7501417B2 (en) 2002-03-13 2009-03-10 Janssen Pharmaceutica, N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
DK1485348T3 (da) 2002-03-13 2008-09-29 Janssen Pharmaceutica Nv Carbonylamino-derivater som nye inhibitorer af histandeacetylase
AU2003218735B2 (en) * 2002-03-13 2009-03-12 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
PL214279B1 (pl) 2002-03-13 2013-07-31 Janssen Pharmaceutica Nv Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania
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