HK1080465A1 - 作為組蛋白脫乙酰酶新穎抑制劑的磺酰基氨基衍生物 - Google Patents

作為組蛋白脫乙酰酶新穎抑制劑的磺酰基氨基衍生物

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Publication number
HK1080465A1
HK1080465A1 HK06100206.4A HK06100206A HK1080465A1 HK 1080465 A1 HK1080465 A1 HK 1080465A1 HK 06100206 A HK06100206 A HK 06100206A HK 1080465 A1 HK1080465 A1 HK 1080465A1
Authority
HK
Hong Kong
Prior art keywords
sulfonylamino
derivatives
histone deacetylase
novel inhibitors
inhibitors
Prior art date
Application number
HK06100206.4A
Other languages
English (en)
Inventor
Emelen Kristof Van
Leo Jacobus Jozef Backx
Brandt Sven Franciscus Anna Van
Patrick René Angibaud
Isabelle Noëlle Constance Pilatte
Marc Gustaaf Celine Verdonck
Winter Hans Louis Jos De
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1080465A1 publication Critical patent/HK1080465A1/zh

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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HK06100206.4A 2002-03-13 2006-01-05 作為組蛋白脫乙酰酶新穎抑制劑的磺酰基氨基衍生物 HK1080465A1 (zh)

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EA007270B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н.В. Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы
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US7205304B2 (en) * 2002-03-13 2007-04-17 Janssen Pharmaceutica N.V. Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
ATE396971T1 (de) 2002-03-13 2008-06-15 Janssen Pharmaceutica Nv Sulfonylaminoderivate als neue inhibitoren von histondeacetylase
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
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WO2005011656A2 (en) 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
BRPI0412343A (pt) 2003-07-30 2006-09-05 Xenon Pharmaceuticals Inc derivados de piridazina e seu uso como agentes terapêuticos
ATE532772T1 (de) 2003-07-30 2011-11-15 Xenon Pharmaceuticals Inc Piperazinderivate und deren verwendung als therapeutische mittel
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