ATE539073T1 - Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase - Google Patents
Heterocyclylalkylderivate als neue inhibitoren von histondeacetylaseInfo
- Publication number
- ATE539073T1 ATE539073T1 AT07703885T AT07703885T ATE539073T1 AT E539073 T1 ATE539073 T1 AT E539073T1 AT 07703885 T AT07703885 T AT 07703885T AT 07703885 T AT07703885 T AT 07703885T AT E539073 T1 ATE539073 T1 AT E539073T1
- Authority
- AT
- Austria
- Prior art keywords
- histone deacetylase
- heterocyclylalkyl
- derivatives
- new inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100561 | 2006-01-19 | ||
| PCT/EP2007/050370 WO2007082873A1 (en) | 2006-01-19 | 2007-01-16 | Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539073T1 true ATE539073T1 (de) | 2012-01-15 |
Family
ID=36572364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07703885T ATE539073T1 (de) | 2006-01-19 | 2007-01-16 | Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7834011B2 (de) |
| EP (1) | EP1981871B1 (de) |
| JP (1) | JP5225103B2 (de) |
| CN (1) | CN101374828B (de) |
| AT (1) | ATE539073T1 (de) |
| AU (1) | AU2007206941B2 (de) |
| CA (1) | CA2630273C (de) |
| DK (1) | DK1981871T3 (de) |
| ES (1) | ES2376121T3 (de) |
| WO (1) | WO2007082873A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7446109B2 (en) | 2002-03-13 | 2008-11-04 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| KR20040090979A (ko) | 2002-03-13 | 2004-10-27 | 얀센 파마슈티카 엔.브이. | 히스톤 데아세틸레이즈의 신규한 억제제 |
| JP4725945B2 (ja) | 2002-03-13 | 2011-07-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体 |
| US7592450B2 (en) | 2002-03-13 | 2009-09-22 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
| EP1781639B1 (de) | 2004-07-28 | 2012-01-25 | Janssen Pharmaceutica NV | Substituierte indolylalkylaminoderivate als neue inhibitoren von histondeacetylase |
| CA2605272C (en) | 2005-05-18 | 2013-12-10 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| US7884105B2 (en) * | 2005-10-27 | 2011-02-08 | Janssen Pharmaceutica, N.V. | Squaric acid derivatives as inhibitors of histone deacetylase |
| JP5247470B2 (ja) * | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| CN101370791B (zh) * | 2006-01-19 | 2012-05-02 | 詹森药业有限公司 | 作为组蛋白脱乙酰基酶抑制剂的吡啶和嘧啶衍生物 |
| CN101370789B (zh) * | 2006-01-19 | 2012-05-30 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的吡啶和嘧啶衍生物 |
| WO2007082878A1 (en) * | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
| US7834025B2 (en) * | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| CA2735593C (en) | 2008-09-03 | 2017-08-15 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| DK2385832T3 (en) | 2009-01-08 | 2015-09-21 | Curis Inc | Phosphoinositid-3-kinase-inhibitorer med en zink-bindingsdel |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| EP3524324A1 (de) | 2011-02-28 | 2019-08-14 | BioMarin Pharmaceutical Inc. | Histondeacetylaseinhibitoren |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| AU2012226586B2 (en) | 2011-03-09 | 2017-04-13 | Cereno Scientific Ab | Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors |
| PL3111938T3 (pl) | 2011-04-01 | 2019-09-30 | Curis, Inc. | Inhibitor 3-kinazy fosfoinozytydowej z grupą wiążącą cynk |
| US10029988B2 (en) | 2013-03-15 | 2018-07-24 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
| RU2016148863A (ru) * | 2014-05-14 | 2018-06-18 | Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт | Гетероциклические гидроксамовые кислоты в качестве ингибиторов протеин-деацетилазы и двойных ингибиторов протеин-деацетилазы-протеин-киназы и способы их применения |
| CN104356087B (zh) * | 2014-10-11 | 2016-01-13 | 南通大学附属医院 | 一氧化氮供体型hdac抑制剂及其制备方法和医药用途 |
| CN113164466B (zh) | 2018-09-11 | 2025-07-08 | 柯瑞斯公司 | 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗 |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0827742A1 (de) | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Verwendung von Histondeacetylasehemmern zur Behandlung von Fibrose oder Zirrhose |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| EP1472216A2 (de) | 2002-02-07 | 2004-11-03 | Axys Pharmaceuticals | Neue bicyclische hydroxamsäuren als hemmer der histon deacetylase |
| MXPA04007775A (es) | 2002-03-13 | 2004-10-15 | Janssen Pharmaceutica Nv | Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa. |
| EP1485378B1 (de) | 2002-03-13 | 2008-06-18 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase |
| US7446109B2 (en) * | 2002-03-13 | 2008-11-04 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| US7592450B2 (en) * | 2002-03-13 | 2009-09-22 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase |
| KR20040090979A (ko) | 2002-03-13 | 2004-10-27 | 얀센 파마슈티카 엔.브이. | 히스톤 데아세틸레이즈의 신규한 억제제 |
| JP4725945B2 (ja) | 2002-03-13 | 2011-07-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体 |
| ATE399012T1 (de) | 2002-04-03 | 2008-07-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine piperazin verknüpfung als hdac-inhibitoren |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| DE10233412A1 (de) | 2002-07-23 | 2004-02-12 | 4Sc Ag | Neue Verbindungen als Histondeacetylase-Inhibitoren |
| MXPA05001334A (es) | 2002-08-02 | 2005-09-08 | Argenta Discovery Ltd | Acidos tienil-hidroxamicos sustituidos como inhibidores de la desacetilasa de histona. |
| ITMI20030025A1 (it) | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
| TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
| TW200424174A (en) | 2003-02-06 | 2004-11-16 | Hoffmann La Roche | New TP diamide |
| AU2003900608A0 (en) | 2003-02-11 | 2003-02-27 | Fujisawa Pharmaceutical Co., Ltd. | Hdac inhibitor |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| TW200424187A (en) | 2003-04-04 | 2004-11-16 | Hoffmann La Roche | New oxime derivatives and their use as pharmaceutically active agents |
| HRP20090487T1 (hr) | 2003-04-07 | 2009-12-31 | Pharmacyclics | Hidroksamati kao terapeutski agensi |
| NZ545864A (en) | 2003-09-22 | 2009-12-24 | S Bio Pte Ltd | Benzimidazole derivates: preparation and pharmaceutical applications |
| WO2005030704A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| AR046605A1 (es) | 2003-10-27 | 2005-12-14 | S Bio Pte Ltd | Hidroxamatos unidos a biarilo; preparacion y aplicaciones farmaceuticas |
| JP2007509930A (ja) | 2003-10-27 | 2007-04-19 | エス＊バイオ プライベート リミティッド | アシル尿素およびスルホニル尿素が結合したヒドロキサマート |
| GB0402496D0 (en) | 2004-02-04 | 2004-03-10 | Argenta Discovery Ltd | Novel compounds |
| US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| WO2005092899A1 (en) | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
-
2007
- 2007-01-16 US US12/160,120 patent/US7834011B2/en active Active
- 2007-01-16 ES ES07703885T patent/ES2376121T3/es active Active
- 2007-01-16 DK DK07703885.9T patent/DK1981871T3/da active
- 2007-01-16 CA CA2630273A patent/CA2630273C/en active Active
- 2007-01-16 JP JP2008550738A patent/JP5225103B2/ja active Active
- 2007-01-16 AU AU2007206941A patent/AU2007206941B2/en not_active Ceased
- 2007-01-16 EP EP07703885A patent/EP1981871B1/de active Active
- 2007-01-16 WO PCT/EP2007/050370 patent/WO2007082873A1/en not_active Ceased
- 2007-01-16 CN CN2007800032994A patent/CN101374828B/zh active Active
- 2007-01-16 AT AT07703885T patent/ATE539073T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| US7834011B2 (en) | 2010-11-16 |
| CN101374828B (zh) | 2012-09-19 |
| CA2630273C (en) | 2014-06-17 |
| EP1981871B1 (de) | 2011-12-28 |
| ES2376121T3 (es) | 2012-03-09 |
| HK1128286A1 (en) | 2009-10-23 |
| WO2007082873A1 (en) | 2007-07-26 |
| EP1981871A1 (de) | 2008-10-22 |
| JP2009523759A (ja) | 2009-06-25 |
| DK1981871T3 (da) | 2012-02-13 |
| JP5225103B2 (ja) | 2013-07-03 |
| AU2007206941A1 (en) | 2007-07-26 |
| AU2007206941B2 (en) | 2012-09-13 |
| CN101374828A (zh) | 2009-02-25 |
| US20090023726A1 (en) | 2009-01-22 |
| CA2630273A1 (en) | 2007-07-26 |
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