MXPA04008796A - Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona. - Google Patents
Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona.Info
- Publication number
- MXPA04008796A MXPA04008796A MXPA04008796A MXPA04008796A MXPA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A MX PA04008796 A MXPA04008796 A MX PA04008796A
- Authority
- MX
- Mexico
- Prior art keywords
- histone deacetylase
- carbonylamino
- derivatives
- novel inhibitors
- novel
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/402—1-aryl substituted, e.g. piretanide
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract
Esta invencion comprende los compuestos novedosos de la formula (I)(Ver formula I)en la cual n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, y (Ver formula) tienen significados definidos, que poseen actividad enzimatica de inhibicion de desacetilasa de histona; su preparacion, composiciones que los contienen y su uso como una medicina.
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US36379902P | 2002-03-13 | 2002-03-13 | |
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PCT/EP2003/002512 WO2003076395A1 (en) | 2002-03-13 | 2003-03-11 | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
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MXPA04008796A MXPA04008796A (es) | 2002-03-13 | 2003-03-11 | Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona. |
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US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
CN101851173A (zh) | 2001-09-14 | 2010-10-06 | 梅特希尔基因公司 | 组蛋白脱乙酰化酶抑制剂 |
BR0307599A (pt) | 2002-03-13 | 2005-02-01 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inibidores de histona deacetilase |
JP4648628B2 (ja) | 2002-03-13 | 2011-03-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのカルボニルアミノ誘導体 |
EA007272B1 (ru) | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н. В. | Новые ингибиторы гистондеацетилазы |
CN100396679C (zh) * | 2002-03-13 | 2008-06-25 | 詹森药业有限公司 | 用作组蛋白脱乙酰化酶抑制剂的哌嗪基、哌啶基和吗啉基衍生物 |
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
US8163764B2 (en) * | 2002-04-26 | 2012-04-24 | Asan Laboratories Company (Cayman) Limited | Skincare methods |
WO2004054579A1 (en) * | 2002-12-17 | 2004-07-01 | Pfizer Japan Inc. | 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as nr2b receptor antagonists |
WO2005030705A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
EP1778683A1 (en) | 2004-06-14 | 2007-05-02 | F.Hoffmann-La Roche Ag | Thiophene derivatives, their manufacture and use as pharmaceutical agents |
JP2008501665A (ja) | 2004-06-14 | 2008-01-24 | エフ.ホフマン−ラ ロシュ アーゲー | チオフェンヒドロキサム酸誘導体及びhdac阻害剤としてのこれらの使用 |
EP1758880A1 (en) | 2004-06-14 | 2007-03-07 | F.Hoffmann-La Roche Ag | Hydroxamates, their manufacture and use as pharmaceutical agents |
UA86066C2 (ru) * | 2004-07-28 | 2009-03-25 | Янссен Фармацевтика Н.В. | Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы |
CN1993353B (zh) * | 2004-07-28 | 2010-12-01 | 詹森药业有限公司 | 作为组蛋白脱乙酰基酶新抑制剂的取代的吲哚基烷基氨基衍生物 |
AU2005266312C1 (en) * | 2004-07-28 | 2011-06-16 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
WO2006034279A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
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2008
- 2008-09-19 US US12/233,977 patent/US8071615B2/en not_active Expired - Fee Related
-
2011
- 2011-10-24 US US13/280,207 patent/US8394831B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2306858T3 (es) | 2008-11-16 |
JP2005519950A (ja) | 2005-07-07 |
KR20040090981A (ko) | 2004-10-27 |
EA200401200A1 (ru) | 2005-02-24 |
AU2003212336B2 (en) | 2008-12-18 |
EP1485348B1 (en) | 2008-06-11 |
CA2476067A1 (en) | 2003-09-18 |
CN1642907A (zh) | 2005-07-20 |
PL370982A1 (en) | 2005-06-13 |
HRP20040805A2 (en) | 2005-04-30 |
BR0307607A (pt) | 2004-12-21 |
JP4648628B2 (ja) | 2011-03-09 |
US20050148613A1 (en) | 2005-07-07 |
EA007908B1 (ru) | 2007-02-27 |
CN100503599C (zh) | 2009-06-24 |
CA2476067C (en) | 2011-09-20 |
EP1485348A1 (en) | 2004-12-15 |
TW200404794A (en) | 2004-04-01 |
DK1485348T3 (da) | 2008-09-29 |
NO20044146L (no) | 2004-09-30 |
US20090042920A1 (en) | 2009-02-12 |
WO2003076395A1 (en) | 2003-09-18 |
AU2003212336A1 (en) | 2003-09-22 |
NZ534831A (en) | 2007-01-26 |
PL205531B1 (pl) | 2010-04-30 |
US8071615B2 (en) | 2011-12-06 |
US7446109B2 (en) | 2008-11-04 |
DE60321548D1 (de) | 2008-07-24 |
ATE398105T1 (de) | 2008-07-15 |
OA12789A (en) | 2006-07-10 |
AR039564A1 (es) | 2005-02-23 |
US20120041001A1 (en) | 2012-02-16 |
US8394831B2 (en) | 2013-03-12 |
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