DE60321548D1 - Carbonylamino- derivativate als neue inhibitoren von histone deacetylase - Google Patents
Carbonylamino- derivativate als neue inhibitoren von histone deacetylaseInfo
- Publication number
- DE60321548D1 DE60321548D1 DE60321548T DE60321548T DE60321548D1 DE 60321548 D1 DE60321548 D1 DE 60321548D1 DE 60321548 T DE60321548 T DE 60321548T DE 60321548 T DE60321548 T DE 60321548T DE 60321548 D1 DE60321548 D1 DE 60321548D1
- Authority
- DE
- Germany
- Prior art keywords
- carbonylamin
- derivatives
- histone deacetylase
- new inhibitors
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical class N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
BR0212510A (pt) | 2001-09-14 | 2004-08-24 | Methylgene Inc | Inibidor de histona desacetilase, composto e composição |
US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
PL214279B1 (pl) | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
AU2003218735B2 (en) * | 2002-03-13 | 2009-03-12 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
DK1485348T3 (da) | 2002-03-13 | 2008-09-29 | Janssen Pharmaceutica Nv | Carbonylamino-derivater som nye inhibitorer af histandeacetylase |
US7501417B2 (en) | 2002-03-13 | 2009-03-10 | Janssen Pharmaceutica, N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
US8163764B2 (en) * | 2002-04-26 | 2012-04-24 | Asan Laboratories Company (Cayman) Limited | Skincare methods |
CA2510322A1 (en) * | 2002-12-17 | 2004-07-01 | Pfizer Inc. | 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as nr2b receptor antagonists |
WO2005030704A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
EP1778683A1 (de) | 2004-06-14 | 2007-05-02 | F.Hoffmann-La Roche Ag | Thiophenderivate, ihre herstellung und ihre verwendung als pharmazeutische mittel |
EP1758881A1 (de) | 2004-06-14 | 2007-03-07 | F.Hoffmann-La Roche Ag | Hydroxamische thiophensäurederivate und deren verwendung als hdac-hemmer |
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RU2456990C2 (ru) | 2006-09-15 | 2012-07-27 | Янссен Фармацевтика Нв | Комбинации специфичных ингибиторов гистоновых деацетилаз класса i с ингибиторами протеасом |
GB0901749D0 (en) | 2009-02-03 | 2009-03-11 | Oxford Nanopore Tech Ltd | Adaptor method |
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2003
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- 2003-03-11 ES ES03708215T patent/ES2306858T3/es not_active Expired - Lifetime
- 2003-03-11 WO PCT/EP2003/002512 patent/WO2003076395A1/en active IP Right Grant
- 2003-03-11 JP JP2003574617A patent/JP4648628B2/ja not_active Expired - Lifetime
- 2003-03-11 EP EP03708215A patent/EP1485348B1/de not_active Expired - Lifetime
- 2003-03-11 OA OA1200400243A patent/OA12789A/en unknown
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- 2003-03-11 CA CA2476067A patent/CA2476067C/en not_active Expired - Lifetime
- 2003-03-11 KR KR10-2004-7011327A patent/KR20040090981A/ko not_active Application Discontinuation
- 2003-03-11 US US10/507,788 patent/US7446109B2/en active Active
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- 2003-03-11 AU AU2003212336A patent/AU2003212336B2/en not_active Ceased
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- 2003-03-11 CN CNB038058847A patent/CN100503599C/zh not_active Expired - Lifetime
- 2003-03-12 AR ARP030100852A patent/AR039564A1/es not_active Application Discontinuation
- 2003-03-12 TW TW092105281A patent/TW200404794A/zh unknown
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2004
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- 2004-09-30 NO NO20044146A patent/NO20044146L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
CA2476067C (en) | 2011-09-20 |
CN1642907A (zh) | 2005-07-20 |
MXPA04008796A (es) | 2004-11-26 |
HRP20040805A2 (en) | 2005-04-30 |
CN100503599C (zh) | 2009-06-24 |
JP4648628B2 (ja) | 2011-03-09 |
PL205531B1 (pl) | 2010-04-30 |
AU2003212336A1 (en) | 2003-09-22 |
ES2306858T3 (es) | 2008-11-16 |
US8071615B2 (en) | 2011-12-06 |
EA007908B1 (ru) | 2007-02-27 |
AU2003212336B2 (en) | 2008-12-18 |
BR0307607A (pt) | 2004-12-21 |
EA200401200A1 (ru) | 2005-02-24 |
EP1485348B1 (de) | 2008-06-11 |
NZ534831A (en) | 2007-01-26 |
US8394831B2 (en) | 2013-03-12 |
KR20040090981A (ko) | 2004-10-27 |
CA2476067A1 (en) | 2003-09-18 |
DK1485348T3 (da) | 2008-09-29 |
JP2005519950A (ja) | 2005-07-07 |
ATE398105T1 (de) | 2008-07-15 |
TW200404794A (en) | 2004-04-01 |
US20050148613A1 (en) | 2005-07-07 |
US7446109B2 (en) | 2008-11-04 |
PL370982A1 (en) | 2005-06-13 |
OA12789A (en) | 2006-07-10 |
EP1485348A1 (de) | 2004-12-15 |
AR039564A1 (es) | 2005-02-23 |
NO20044146L (no) | 2004-09-30 |
WO2003076395A1 (en) | 2003-09-18 |
US20090042920A1 (en) | 2009-02-12 |
US20120041001A1 (en) | 2012-02-16 |
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