ATE398615T1 - Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase - Google Patents

Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase

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Publication number
ATE398615T1
ATE398615T1 AT03711979T AT03711979T ATE398615T1 AT E398615 T1 ATE398615 T1 AT E398615T1 AT 03711979 T AT03711979 T AT 03711979T AT 03711979 T AT03711979 T AT 03711979T AT E398615 T1 ATE398615 T1 AT E398615T1
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AT
Austria
Prior art keywords
piperazinyl
piperidinyl
histone deacetylase
new inhibitors
morpholinyl derivatives
Prior art date
Application number
AT03711979T
Other languages
English (en)
Inventor
Emelen Kristof Van
Original Assignee
Janssen Pharmaceutica Nv
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Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE398615T1 publication Critical patent/ATE398615T1/de

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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AT03711979T 2002-03-13 2003-03-11 Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase ATE398615T1 (de)

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EP1429765A2 (de) 2001-09-14 2004-06-23 Methylgene, Inc. Histone deacetylase-hemmer
IL164007A0 (en) 2002-03-13 2005-12-18 Janssen Pharmaceutica Nv New inhibitors of histone deacetylase
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ATE398105T1 (de) * 2002-03-13 2008-07-15 Janssen Pharmaceutica Nv Carbonylamino- derivativate als neue inhibitoren von histone deacetylase
BR0307599A (pt) 2002-03-13 2005-02-01 Janssen Pharmaceutica Nv Derivados de sulfonilamino como inibidores de histona deacetilase
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
EP1663953A1 (de) 2003-09-24 2006-06-07 Methylgene, Inc. Histondeacetylase-hemmer
US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
WO2005121134A1 (en) 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Thiophene derivatives, their manufacture and use as pharmaceutical agents
CN1964962A (zh) 2004-06-14 2007-05-16 霍夫曼-拉罗奇有限公司 噻吩异羟肟酸衍生物以及它们作为hdac抑制剂的应用
MX2007001120A (es) 2004-07-28 2007-03-15 Janssen Pharmaceutica Nv Derivados de indolil alquil sustituidos como nuevos inhibidores de la histona desacetilasa.
ATE432274T1 (de) * 2004-07-28 2009-06-15 Janssen Pharmaceutica Nv Substituierte propenylpiperazinderivate als neue inhibitoren von histondeacetylase
UA86066C2 (ru) * 2004-07-28 2009-03-25 Янссен Фармацевтика Н.В. Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы
BRPI0515015A (pt) * 2004-08-11 2008-07-01 Kyorin Seiyaku Kk derivado cìclico de ácido aminobenzóico; medicamento; agonista ppar(alpha); agonista duplo ppar(alpha), y; agonista duplo ppar(alpha), (delta); modulador ppar; agente lipìdeo; agente profilático ou terapêutico compreendendo pelo menos um dos derivados cìclicos de ácido aminobenzóico ou sal do mesmo farmacêuticamente aceitável
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