MXPA04008795A - Derivados de piperazinilo, piperidinilo y morfolino como novedosos inhibidores de la desacetilasa de histona. - Google Patents

Derivados de piperazinilo, piperidinilo y morfolino como novedosos inhibidores de la desacetilasa de histona.

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Publication number
MXPA04008795A
MXPA04008795A MXPA04008795A MXPA04008795A MXPA04008795A MX PA04008795 A MXPA04008795 A MX PA04008795A MX PA04008795 A MXPA04008795 A MX PA04008795A MX PA04008795 A MXPA04008795 A MX PA04008795A MX PA04008795 A MXPA04008795 A MX PA04008795A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
piperazinyl
morpholinyl
piperidinyl
derivatives
Prior art date
Application number
MXPA04008795A
Other languages
English (en)
Inventor
Emelen Kristof Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04008795A publication Critical patent/MXPA04008795A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

Esta invencion comprende los compuestos novedosos de la formula (I)(Ver formula I)en la cual t, R1, R2. L, Q, X, Y, Z y (Ver formula) tienen significados definidos, que poseen actividad enzimatica de inhibicion de la desacetilasa de histona; su preparacion, composiciones que los contienen y su empleo como una medicina.
MXPA04008795A 2002-03-13 2003-03-11 Derivados de piperazinilo, piperidinilo y morfolino como novedosos inhibidores de la desacetilasa de histona. MXPA04008795A (es)

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PCT/EP2003/002510 WO2003076438A1 (en) 2002-03-13 2003-03-11 Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase

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EA007272B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н. В. Новые ингибиторы гистондеацетилазы
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US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
CA2566515A1 (en) 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Thiophene hydroxamic acid derivatives and their use as hdac inhibitors
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