ATE513818T1 - Chinazolinonderivate als tubulinpolymerisationshemmer - Google Patents

Chinazolinonderivate als tubulinpolymerisationshemmer

Info

Publication number
ATE513818T1
ATE513818T1 AT09724207T AT09724207T ATE513818T1 AT E513818 T1 ATE513818 T1 AT E513818T1 AT 09724207 T AT09724207 T AT 09724207T AT 09724207 T AT09724207 T AT 09724207T AT E513818 T1 ATE513818 T1 AT E513818T1
Authority
AT
Austria
Prior art keywords
tubulin polymerization
polymerization inhibitors
quinazolinone derivatives
formula
inhibitors
Prior art date
Application number
AT09724207T
Other languages
English (en)
Inventor
Eddy Jean Edgard Freyne
Laurence Anne Mevellec
Jorge Eduardo Vialard
Christophe Meyer
Elisabeth Therese Jeanne Pasquier
Xavier Marc Bourdrez
Patrick Rene Angibaud
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE513818T1 publication Critical patent/ATE513818T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT09724207T 2008-03-27 2009-03-26 Chinazolinonderivate als tubulinpolymerisationshemmer ATE513818T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153428 2008-03-27
PCT/EP2009/053604 WO2009118384A1 (en) 2008-03-27 2009-03-26 Quinazolinone derivatives as tubulin polymerization inhibitors

Publications (1)

Publication Number Publication Date
ATE513818T1 true ATE513818T1 (de) 2011-07-15

Family

ID=40445540

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09724207T ATE513818T1 (de) 2008-03-27 2009-03-26 Chinazolinonderivate als tubulinpolymerisationshemmer

Country Status (8)

Country Link
US (1) US8168644B2 (de)
EP (1) EP2260026B1 (de)
JP (1) JP5464609B2 (de)
AT (1) ATE513818T1 (de)
AU (1) AU2009228945B2 (de)
CA (1) CA2716088C (de)
ES (1) ES2367760T3 (de)
WO (1) WO2009118384A1 (de)

Families Citing this family (8)

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TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用
US9719970B2 (en) 2012-11-30 2017-08-01 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin D metabolites
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US20240208969A1 (en) * 2021-04-12 2024-06-27 Impact Therapeutics (Shanghai), Inc. Substituted fused bicyclic compounds as parp inhibitors and the use thereof

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Also Published As

Publication number Publication date
US20110028433A1 (en) 2011-02-03
JP2011515451A (ja) 2011-05-19
ES2367760T3 (es) 2011-11-08
AU2009228945A1 (en) 2009-10-01
WO2009118384A1 (en) 2009-10-01
US8168644B2 (en) 2012-05-01
CA2716088A1 (en) 2009-10-01
EP2260026B1 (de) 2011-06-22
CA2716088C (en) 2017-03-07
EP2260026A1 (de) 2010-12-15
JP5464609B2 (ja) 2014-04-09
AU2009228945B2 (en) 2013-05-02

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