PE20030044A1 - Isoxazolinonas biciclicas de formula i - Google Patents

Isoxazolinonas biciclicas de formula i

Info

Publication number
PE20030044A1
PE20030044A1 PE2001001126A PE2001001126A PE20030044A1 PE 20030044 A1 PE20030044 A1 PE 20030044A1 PE 2001001126 A PE2001001126 A PE 2001001126A PE 2001001126 A PE2001001126 A PE 2001001126A PE 20030044 A1 PE20030044 A1 PE 20030044A1
Authority
PE
Peru
Prior art keywords
alkyl
isoxazolinones
bicycle
het
formula
Prior art date
Application number
PE2001001126A
Other languages
English (en)
Inventor
Michael J Genin
Michael R Barbachyn
Hester
Paul D Johnson
Fred L Ciske
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20030044A1 publication Critical patent/PE20030044A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

SE REFIERE A ISOXAZOLINONAS BICICLICAS DE FORMULA I DONDE Y ES -NHC(=W)R2, -O-HET, -S-HET, -NH-HET; W ES O, S; X ES -S(=O)m-, -CHR3-; R1 ES ALQUILO C1-C8, -C(=O)R4, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, CICLOPROPILO, ENTRE OTROS; R3 ES H, ALQUILO C1-C4; R4 ES H, ALQUILO C1-C6, ENTRE OTROS; R5 ES HALO, CH, NO2, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, FENILO, HET. UN COMPUESTO PREFERIDO ES N-{[4-(N-FORMIL-2-METILINDOLINIL)-5-OXO-ISOXAZOL-2-IL]METIL}ACETAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS DERIVADOS DE ISOXAZOLINONAS BICICLICAS SON UTILES COMO AGENTES ANTIBACTERIANOS
PE2001001126A 2000-11-17 2001-11-13 Isoxazolinonas biciclicas de formula i PE20030044A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24955100P 2000-11-17 2000-11-17

Publications (1)

Publication Number Publication Date
PE20030044A1 true PE20030044A1 (es) 2003-02-09

Family

ID=22943978

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001126A PE20030044A1 (es) 2000-11-17 2001-11-13 Isoxazolinonas biciclicas de formula i

Country Status (6)

Country Link
US (1) US6825225B2 (es)
EP (1) EP1334090A1 (es)
JP (1) JP2004536087A (es)
CA (1) CA2422745A1 (es)
PE (1) PE20030044A1 (es)
WO (1) WO2002102785A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035073A1 (en) 2001-10-25 2003-05-01 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039690A (en) 1987-10-09 1991-08-13 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5032605A (en) 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5036092A (en) 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US5164510A (en) 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
DE4425609A1 (de) 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
HUP0103082A3 (en) 1998-06-05 2002-12-28 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
WO2002102785A1 (en) 2002-12-27
CA2422745A1 (en) 2002-12-27
EP1334090A1 (en) 2003-08-13
JP2004536087A (ja) 2004-12-02
US6825225B2 (en) 2004-11-30
US20040116413A1 (en) 2004-06-17

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Legal Events

Date Code Title Description
FC Refusal