DE3582057D1 - Amidinverbindungen. - Google Patents

Amidinverbindungen.

Info

Publication number
DE3582057D1
DE3582057D1 DE8585903394T DE3582057T DE3582057D1 DE 3582057 D1 DE3582057 D1 DE 3582057D1 DE 8585903394 T DE8585903394 T DE 8585903394T DE 3582057 T DE3582057 T DE 3582057T DE 3582057 D1 DE3582057 D1 DE 3582057D1
Authority
DE
Germany
Prior art keywords
amidinverbindungen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585903394T
Other languages
English (en)
Inventor
Setsurou Fujii
Toshiyuki Okutome
Toyoo Nakayama
Shigeki Nunomura
Kimio Sudo
Shinichi Watanabe
Masateru Kurumi
Takuo Aoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii and Co Ltd
Original Assignee
Torii and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii and Co Ltd filed Critical Torii and Co Ltd
Application granted granted Critical
Publication of DE3582057D1 publication Critical patent/DE3582057D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8585903394T 1984-07-25 1985-07-12 Amidinverbindungen. Expired - Fee Related DE3582057D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15504584A JPS6133173A (ja) 1984-07-25 1984-07-25 アミジン化合物
PCT/JP1985/000392 WO1986000893A1 (en) 1984-07-25 1985-07-12 Novel amidine compounds

Publications (1)

Publication Number Publication Date
DE3582057D1 true DE3582057D1 (en) 1991-04-11

Family

ID=15597463

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585903394T Expired - Fee Related DE3582057D1 (en) 1984-07-25 1985-07-12 Amidinverbindungen.

Country Status (19)

Country Link
US (2) US4777182A (de)
EP (1) EP0190356B1 (de)
JP (1) JPS6133173A (de)
KR (2) KR870001087B1 (de)
AU (1) AU567039B2 (de)
CA (1) CA1254205A (de)
CS (1) CS255891B2 (de)
DD (1) DD235637A5 (de)
DE (1) DE3582057D1 (de)
DK (1) DK169069B1 (de)
ES (1) ES8607218A1 (de)
FI (1) FI78461C (de)
HU (1) HU195769B (de)
MX (1) MX160912A (de)
NO (1) NO163954C (de)
PH (1) PH20585A (de)
SU (1) SU1456008A3 (de)
WO (1) WO1986000893A1 (de)
ZA (1) ZA855552B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3824236C1 (de) * 1988-07-16 1989-12-28 Heidelberger Druckmaschinen Ag, 6900 Heidelberg, De
CA2032420A1 (en) * 1989-12-22 1991-06-23 Akira Okuyama Guanidinobenzene derivatives
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
RU2142799C1 (ru) * 1995-01-05 1999-12-20 Тории Фармасьютикал Ко., Лтд Тромболитические средства
ATE222583T1 (de) * 1995-01-05 2002-09-15 Torii Pharmaceutical Co Ltd Derivate substituierter amidinonaphthylester
AU736951C (en) 1998-03-19 2003-02-20 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
WO2001077082A1 (fr) * 1999-06-02 2001-10-18 Torii Pharmaceutical Co., Ltd. Derives de naphtalene
AU2000252458A1 (en) * 2000-06-08 2001-12-17 Shizuoka Coffein Co., Ltd. Benzene derivatives
EP1884236B1 (de) * 2005-05-17 2011-03-02 Santen Pharmaceutical Co., Ltd. Ein aminderivat als wirkstoff enthaltender angiogeneseinhibitor
ES2354223T3 (es) * 2005-05-17 2011-03-11 Santen Pharmaceutical Co., Ltd. Derivados de amidina para uso en la prevención o el tratamiento de glaucoma.
WO2008058167A2 (en) * 2006-11-07 2008-05-15 Case Western Reserve University Method for treating disorders associated with complement activation
JP6042330B2 (ja) 2010-07-09 2016-12-14 ビーエイチヴィ ファーマ、インコーポレイテッド レモグリフロジンを含めた半減期が短い医薬品のための組合せ即時／遅延放出送達システム
JP6252991B2 (ja) * 2012-07-04 2017-12-27 味の素株式会社 ナファモスタットメシル酸塩の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292429A (en) * 1978-03-08 1981-09-29 Ciba-Geigy Corporation Imidazole urea and amido compounds
JPS57179146A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine compound
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
JPS60130561A (ja) * 1983-12-16 1985-07-12 Torii Yakuhin Kk アミジン誘導体およびそれを含む強心剤

Also Published As

Publication number Publication date
HUT42433A (en) 1987-07-28
US4820730A (en) 1989-04-11
JPS6133173A (ja) 1986-02-17
WO1986000893A1 (en) 1986-02-13
ZA855552B (en) 1986-03-26
DD235637A5 (de) 1986-05-14
NO163954B (no) 1990-05-07
HU195769B (en) 1988-07-28
EP0190356A4 (de) 1987-12-09
FI78461B (fi) 1989-04-28
CS255891B2 (en) 1988-03-15
AU4549285A (en) 1986-02-25
PH20585A (en) 1987-02-20
AU567039B2 (en) 1987-11-05
US4777182A (en) 1988-10-11
DK96286D0 (da) 1986-03-03
FI78461C (fi) 1989-08-10
DK96286A (da) 1986-03-03
ES545482A0 (es) 1986-05-16
JPH0461868B2 (de) 1992-10-02
FI860904A0 (fi) 1986-03-04
KR870001087B1 (ko) 1987-06-04
NO163954C (no) 1990-08-15
ES8607218A1 (es) 1986-05-16
CS546385A2 (en) 1987-07-16
EP0190356B1 (de) 1991-03-06
MX160912A (es) 1990-06-14
NO860865L (no) 1986-04-10
CA1254205A (en) 1989-05-16
DK169069B1 (da) 1994-08-08
SU1456008A3 (ru) 1989-01-30
EP0190356A1 (de) 1986-08-13
FI860904A (fi) 1986-03-04
KR860700250A (ko) 1986-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee