GB1184395A - Substituted Piperazine Derivatives - Google Patents

Substituted Piperazine Derivatives

Info

Publication number
GB1184395A
GB1184395A GB918368A GB918368A GB1184395A GB 1184395 A GB1184395 A GB 1184395A GB 918368 A GB918368 A GB 918368A GB 918368 A GB918368 A GB 918368A GB 1184395 A GB1184395 A GB 1184395A
Authority
GB
United Kingdom
Prior art keywords
general formula
alkyl
same meanings
piperazine
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB918368A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyesult Gyogyszer es Tapszergyar
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyesult Gyogyszer es Tapszergyar
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyesult Gyogyszer es Tapszergyar, Egyt Gyogyszervegyeszeti Gyar filed Critical Egyesult Gyogyszer es Tapszergyar
Publication of GB1184395A publication Critical patent/GB1184395A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A63—SPORTS; GAMES; AMUSEMENTS
    • A63F—CARD, BOARD, OR ROULETTE GAMES; INDOOR GAMES USING SMALL MOVING PLAYING BODIES; VIDEO GAMES; GAMES NOT OTHERWISE PROVIDED FOR
    • A63F2250/00—Miscellaneous game characteristics
    • A63F2250/04—Miscellaneous game characteristics containing a liquid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,184,395. Substituted piperazine derivatives. EGYESULT CYOGYSZER ES TAPSZERGYAR. 26 Feb., 1968 [8 March, 1967 (2)], No. 9183/68. Heading C2C. Novel N - (1 - substituted cycloalkyloxyalkyl) - N<SP>1</SP> - carboalkoxy - piperazine derivatives of the general formula wherein R<SP>1</SP> represents hydrogen, phenyl or monohalogenphenyl, R<SP>2</SP> represents a C 1-4 alkyl, m is 0 or an integer from 0 to 12, n is an integer from 4 to 7 and A represents a saturated or unsaturated, straight or branched chain alkylene group of 2 to 5 carbon atoms; and pharmaceutically acceptable acid addition salts and quaternary ammonium derivatives are prepared by reacting a tertiary alcohol of the general formula wherein R<SP>1</SP>, m and n have the same meanings as above, or an alkali salt thereof with an N-halogen alkyl-N<SP>1</SP>-carboalkoxy-piperazine of the general formula wherein R<SP>2</SP> and A have the same meanings as above and the Hal represents a halogen atom; or reacting a substituted piperazine derivative of the general formula wherein R<SP>1</SP>, A, m and n have the same meanings as above and R<SP>3</SP> represents C 1-4 alkyl, with a chloroformic acid ester of the general formula Cl-COOR<SP>2</SP> wherein R<SP>2</SP> has the same meaning as above, in the presence of an anhydrous solvent and of a basic condensing agent and optionally converting the obtained product into a pharmaceutically acceptable acid addition salt or a quaternary ammonium derivative. Pharmaceutical compositions of the above compounds have a spasmolytic effect and also a marked analgetic activity.
GB918368A 1967-03-08 1968-02-26 Substituted Piperazine Derivatives Expired GB1184395A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUGY001348 1967-03-08
HUGY001347 1967-03-08

Publications (1)

Publication Number Publication Date
GB1184395A true GB1184395A (en) 1970-03-18

Family

ID=26318484

Family Applications (1)

Application Number Title Priority Date Filing Date
GB918368A Expired GB1184395A (en) 1967-03-08 1968-02-26 Substituted Piperazine Derivatives

Country Status (1)

Country Link
GB (1) GB1184395A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037982A1 (en) * 1996-04-10 1997-10-16 Ucb S.A. Novel substituted [2-(1-piperazinyl)ethoxy]methyl

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037982A1 (en) * 1996-04-10 1997-10-16 Ucb S.A. Novel substituted [2-(1-piperazinyl)ethoxy]methyl
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
EA000831B1 (en) * 1996-04-10 2000-04-24 ЮСиБи С.А. Novel substituted [2-(1-piperazinyle)etoxy]methyl compounds, method for preparing said compounds and the use thereof
US6140501A (en) * 1996-04-10 2000-10-31 Ucb, S.A. Substituted [2-(1-piperazinyl)ethoxy]methyl compounds
US6255487B1 (en) 1996-04-10 2001-07-03 Ucb, S.A. Process of preparing [2-(1-piperazinyl)ethoxy]methyl compounds

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee