ES8500907A1 - Procedimiento para preparar derivados de (indenil-2)-2-imidazolina - Google Patents

Procedimiento para preparar derivados de (indenil-2)-2-imidazolina

Info

Publication number
ES8500907A1
ES8500907A1 ES530681A ES530681A ES8500907A1 ES 8500907 A1 ES8500907 A1 ES 8500907A1 ES 530681 A ES530681 A ES 530681A ES 530681 A ES530681 A ES 530681A ES 8500907 A1 ES8500907 A1 ES 8500907A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
compositions containing
imidazolines
indenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530681A
Other languages
English (en)
Other versions
ES530681A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES8500907A1 publication Critical patent/ES8500907A1/es
Publication of ES530681A0 publication Critical patent/ES530681A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE (INDENIL-2)-2-IMIDAZOLINA Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R2 ES HIDROGENO O METILO; Y R1 PUEDE SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA DIAMINA DE FORMULA R2NHCH2CH2NH2 EN LAS QUE R ES METILO O ETILO Y R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN PRESENCIA DE TRIMETILALUMINIO EN UN DISOLVENTE ORGANICO INERTE A TEMPERATURAS ENTRE 0JC Y LA DE REFLUJO DE LA MEZCLA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA DEPRESION, HIPOTENSION Y EL ILEO PARALITICO POST-OPERATORIO.
ES530681A 1983-03-18 1984-03-16 Procedimiento para preparar derivados de (indenil-2)-2-imidazolina Granted ES530681A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8304524A FR2542738A1 (fr) 1983-03-18 1983-03-18 Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Publications (2)

Publication Number Publication Date
ES8500907A1 true ES8500907A1 (es) 1984-11-01
ES530681A0 ES530681A0 (es) 1984-11-01

Family

ID=9287026

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530681A Granted ES530681A0 (es) 1983-03-18 1984-03-16 Procedimiento para preparar derivados de (indenil-2)-2-imidazolina

Country Status (16)

Country Link
US (1) US4559356A (es)
EP (1) EP0125937A2 (es)
JP (1) JPS59186962A (es)
AU (1) AU559177B2 (es)
CA (1) CA1217776A (es)
DK (1) DK112884A (es)
ES (1) ES530681A0 (es)
FI (1) FI841077A (es)
FR (1) FR2542738A1 (es)
GR (1) GR81885B (es)
HU (1) HU191597B (es)
IL (1) IL71270A0 (es)
NO (1) NO841021L (es)
NZ (1) NZ207524A (es)
PT (1) PT78272B (es)
ZA (1) ZA841985B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166937B1 (en) * 1984-06-06 1991-08-28 Abbott Laboratories Adrenergic compounds
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
FR2787451B1 (fr) * 1998-12-18 2001-01-26 Adir Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2388979C (en) * 1999-10-29 2010-09-14 Orion Corporation Treatment or prevention of hypotension and shock with use of an imidazole derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731471A (en) * 1956-01-17 Nxg hi
US2842478A (en) * 1955-08-25 1958-07-08 Pfizer & Co C Tetrahydrozoline-central nervous system depressant veterinary compositions and method of using same
US3287469A (en) * 1963-09-27 1966-11-22 Du Pont Naphthyl-and indanylimidazolines

Also Published As

Publication number Publication date
US4559356A (en) 1985-12-17
NO841021L (no) 1984-09-19
NZ207524A (en) 1986-07-11
IL71270A0 (en) 1984-06-29
FI841077A (fi) 1984-09-19
ZA841985B (en) 1984-10-31
DK112884D0 (da) 1984-02-28
AU2581984A (en) 1984-09-20
CA1217776A (en) 1987-02-10
AU559177B2 (en) 1987-02-26
PT78272A (fr) 1984-04-01
FR2542738A1 (fr) 1984-09-21
FI841077A0 (fi) 1984-03-16
HU191597B (en) 1987-03-30
GR81885B (es) 1984-12-12
HUT34165A (en) 1985-02-28
PT78272B (fr) 1986-08-08
ES530681A0 (es) 1984-11-01
DK112884A (da) 1984-09-19
EP0125937A2 (fr) 1984-11-21
JPS59186962A (ja) 1984-10-23

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