AU1234488A - New 2-(2,3-dihydro-2-oxo-3-benzofuranyl) acetic acid derivatives, processes for preparing them and the pharmaceutical compositions which contain them - Google Patents
New 2-(2,3-dihydro-2-oxo-3-benzofuranyl) acetic acid derivatives, processes for preparing them and the pharmaceutical compositions which contain themInfo
- Publication number
- AU1234488A AU1234488A AU12344/88A AU1234488A AU1234488A AU 1234488 A AU1234488 A AU 1234488A AU 12344/88 A AU12344/88 A AU 12344/88A AU 1234488 A AU1234488 A AU 1234488A AU 1234488 A AU1234488 A AU 1234488A
- Authority
- AU
- Australia
- Prior art keywords
- radical
- carbon atoms
- denotes
- linear
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PKMIRTMPTNEWOJ-UHFFFAOYSA-N 2-(2-oxo-3h-1-benzofuran-3-yl)acetic acid Chemical class C1=CC=C2C(CC(=O)O)C(=O)OC2=C1 PKMIRTMPTNEWOJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 alkyl radical Chemical class 0.000 abstract 18
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- 150000003254 radicals Chemical class 0.000 abstract 5
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 3
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical group C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
The invention relates to new 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds of general formula I: <IMAGE> (I) in which: R1 denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms or a phenyl radical optionally substituted with a halogen atom or with an alkoxy radical containing 1 to 4 carbon atoms or an alkyl radical having 1 to 4 carbon atoms, R2 denotes a hydrogen or halogen atom, a hydroxyl radical, an alkyl radical having 1 to 4 carbon atoms or an alkoxy radical containing 1 to 4 carbon atoms, R denotes a hydroxyl radical, a linear or branched alkoxy radical having 1 to 4 carbon atoms, a benzyloxy radical or a radical of general formula A: <IMAGE> (A) in which: X and Y, which may be identical or different, each denote a linear or branched alkyl radical containing 1 to 5 carbon atoms, a radical of general formula A1 (CHZ-COOH)-, in which Z denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms, a hydroxyalkyl radical having 1 to 4 carbon atoms, a 4-imidazolylmethylene radical or a benzyl radical optionally substituted with an alkyl radical having 1 to 4 carbon atoms or with a hydroxyl radical; a radical of general formula A2 (CH2W)-in which W denotes a linear or branched dialkylaminomethylene radical having 3 to 9 carbon atoms, a 2-pyrrolidinyl radical optionally substituted with an alkyl radical having 1 to 4 carbon atoms, a benzyl radical, a 1-isochromanyl radical or a 1-isoquinolyl radical, or form, together with the nitrogen to which they are attached, a 2-carboxy-2-pyrrolidinyl radical, a 4-morpholinyl radical, a piperidino radical optionally substituted with a phenyl radical or with an alkoxyphenyl radical having 7 to 10 carbon atoms, or a 1-piperazinly radical.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8702630 | 1987-02-27 | ||
| FR8702630A FR2611713B1 (en) | 1987-02-27 | 1987-02-27 | NOVEL ACID DERIVATIVES (2,3-DIHYDRO-2 OXO-2 BENZOFURANNYL-3) -2 ACETIC, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1234488A true AU1234488A (en) | 1988-09-01 |
| AU598345B2 AU598345B2 (en) | 1990-06-21 |
Family
ID=9348401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU12344/88A Ceased AU598345B2 (en) | 1987-02-27 | 1988-02-26 | New 2-(2,3-dihydro-2-oxo-3-benzofuranyl) acetic acid derivatives, processes for preparing them and the pharmaceutical compositions which contain them |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4859700A (en) |
| EP (1) | EP0282390B1 (en) |
| JP (1) | JPS63227582A (en) |
| AT (1) | ATE63309T1 (en) |
| AU (1) | AU598345B2 (en) |
| CA (1) | CA1313871C (en) |
| DE (1) | DE3862660D1 (en) |
| DK (1) | DK167063B1 (en) |
| ES (1) | ES2009553A6 (en) |
| FR (1) | FR2611713B1 (en) |
| GR (1) | GR1000125B (en) |
| IE (1) | IE60500B1 (en) |
| NZ (1) | NZ223663A (en) |
| OA (1) | OA08813A (en) |
| PT (1) | PT86851B (en) |
| ZA (1) | ZA881383B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2061953T3 (en) * | 1988-11-24 | 1994-12-16 | Akzo Nv | A PROCEDURE FOR PREPARING A PHARMACEUTICAL COMPOSITION. |
| GB9205049D0 (en) * | 1992-03-09 | 1992-04-22 | Ici Plc | Polycyclic dyes |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| EP1303502A2 (en) * | 2000-07-06 | 2003-04-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Tetrahydrobenzothiazole analogues as neuroprotective agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2513698A (en) * | 1945-03-09 | 1950-07-04 | Abbott Lab | 2 (3) benxofuranone derivatives and methods of making them |
| GB1173312A (en) * | 1966-03-17 | 1969-12-10 | Kefalas As | Heterocyclic Compounds |
| GB2042562B (en) * | 1979-02-05 | 1983-05-11 | Sandoz Ltd | Stabilising polymers |
| US4514415A (en) * | 1981-10-28 | 1985-04-30 | Ciba Geigy Corporation | Benzofuran-2(3H)-ones used as anti-inflammatory agents |
| US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| FR2593504B1 (en) * | 1986-01-30 | 1988-12-09 | Ile De France | NOVEL DIHYDROBENZOFURANNE - AND CHROMANE - CARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEUROLEPTICS |
-
1987
- 1987-02-27 FR FR8702630A patent/FR2611713B1/en not_active Expired - Lifetime
-
1988
- 1988-02-01 CA CA000557812A patent/CA1313871C/en not_active Expired - Fee Related
- 1988-02-12 US US07/155,352 patent/US4859700A/en not_active Expired - Fee Related
- 1988-02-26 DK DK104388A patent/DK167063B1/en not_active IP Right Cessation
- 1988-02-26 ZA ZA881383A patent/ZA881383B/en unknown
- 1988-02-26 AU AU12344/88A patent/AU598345B2/en not_active Ceased
- 1988-02-26 IE IE52888A patent/IE60500B1/en not_active IP Right Cessation
- 1988-02-26 GR GR880100111A patent/GR1000125B/en unknown
- 1988-02-26 NZ NZ223663A patent/NZ223663A/en unknown
- 1988-02-26 PT PT86851A patent/PT86851B/en not_active IP Right Cessation
- 1988-02-26 OA OA59290A patent/OA08813A/en unknown
- 1988-02-26 DE DE8888400441T patent/DE3862660D1/en not_active Expired - Lifetime
- 1988-02-26 AT AT88400441T patent/ATE63309T1/en not_active IP Right Cessation
- 1988-02-26 JP JP63044081A patent/JPS63227582A/en active Granted
- 1988-02-26 EP EP19880400441 patent/EP0282390B1/en not_active Expired - Lifetime
- 1988-02-27 ES ES8800577A patent/ES2009553A6/en not_active Expired
-
1989
- 1989-01-17 US US07/298,107 patent/US4885299A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU598345B2 (en) | 1990-06-21 |
| US4859700A (en) | 1989-08-22 |
| IE60500B1 (en) | 1994-07-27 |
| FR2611713A1 (en) | 1988-09-09 |
| FR2611713B1 (en) | 1990-11-30 |
| DK104388A (en) | 1988-08-28 |
| ES2009553A6 (en) | 1989-10-01 |
| ZA881383B (en) | 1988-12-28 |
| DK104388D0 (en) | 1988-02-26 |
| EP0282390A1 (en) | 1988-09-14 |
| GR1000125B (en) | 1991-07-31 |
| PT86851A (en) | 1988-03-01 |
| CA1313871C (en) | 1993-02-23 |
| OA08813A (en) | 1989-03-31 |
| JPS63227582A (en) | 1988-09-21 |
| DK167063B1 (en) | 1993-08-23 |
| ATE63309T1 (en) | 1991-05-15 |
| US4885299A (en) | 1989-12-05 |
| JPH0558633B2 (en) | 1993-08-27 |
| PT86851B (en) | 1992-05-29 |
| GR880100111A (en) | 1988-12-16 |
| DE3862660D1 (en) | 1991-06-13 |
| EP0282390B1 (en) | 1991-05-08 |
| IE880528L (en) | 1988-08-27 |
| NZ223663A (en) | 1990-01-29 |
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