DE60327813D1 - Verfahren zu herstellung von lovastatin. - Google Patents
Verfahren zu herstellung von lovastatin.Info
- Publication number
- DE60327813D1 DE60327813D1 DE60327813T DE60327813T DE60327813D1 DE 60327813 D1 DE60327813 D1 DE 60327813D1 DE 60327813 T DE60327813 T DE 60327813T DE 60327813 T DE60327813 T DE 60327813T DE 60327813 D1 DE60327813 D1 DE 60327813D1
- Authority
- DE
- Germany
- Prior art keywords
- lovastatin
- impure
- preparing
- preparing lovastatin
- lactonisation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title abstract 6
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title abstract 5
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title abstract 5
- 229960004844 lovastatin Drugs 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- QLJODMDSTUBWDW-BXMDZJJMSA-N mevinolinic acid Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C=C21 QLJODMDSTUBWDW-BXMDZJJMSA-N 0.000 abstract 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000333 WO2005035515A1 (en) | 2003-10-14 | 2003-10-14 | A method for the manufacture of lovastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60327813D1 true DE60327813D1 (de) | 2009-07-09 |
Family
ID=34430672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60327813T Expired - Lifetime DE60327813D1 (de) | 2003-10-14 | 2003-10-14 | Verfahren zu herstellung von lovastatin. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7566792B2 (de) |
| EP (1) | EP1673361B1 (de) |
| AT (1) | ATE432270T1 (de) |
| AU (1) | AU2003290396A1 (de) |
| CA (1) | CA2540068C (de) |
| DE (1) | DE60327813D1 (de) |
| ES (1) | ES2325498T3 (de) |
| PT (1) | PT1673361E (de) |
| WO (1) | WO2005035515A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993145B (zh) * | 2011-09-19 | 2015-06-03 | 北大方正集团有限公司 | 一种提取纯化洛伐他汀的方法 |
| EP2597092A1 (de) * | 2011-11-24 | 2013-05-29 | Sterling Biotech Limited | Verfahren zum Reinigen von Lovastatin |
| CN111718317A (zh) * | 2019-03-21 | 2020-09-29 | 福安药业集团烟台只楚药业有限公司 | 一种洛伐他汀的提炼方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0877742B1 (de) * | 1995-12-06 | 2001-08-16 | Balkanpharma-Razgrad AD | Verfahren zur herstellung von lovastatin |
| PL346392A1 (en) * | 1999-06-29 | 2002-02-11 | Kaneka Corp | Process for selective lactonization |
| US6380401B1 (en) * | 1999-10-27 | 2002-04-30 | Merck & Co., Inc. | Lactonization process |
| IN192861B (de) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd |
-
2003
- 2003-10-14 US US10/571,192 patent/US7566792B2/en not_active Expired - Fee Related
- 2003-10-14 AU AU2003290396A patent/AU2003290396A1/en not_active Abandoned
- 2003-10-14 ES ES03782759T patent/ES2325498T3/es not_active Expired - Lifetime
- 2003-10-14 DE DE60327813T patent/DE60327813D1/de not_active Expired - Lifetime
- 2003-10-14 CA CA2540068A patent/CA2540068C/en not_active Expired - Fee Related
- 2003-10-14 PT PT03782759T patent/PT1673361E/pt unknown
- 2003-10-14 EP EP03782759A patent/EP1673361B1/de not_active Expired - Lifetime
- 2003-10-14 WO PCT/IN2003/000333 patent/WO2005035515A1/en active Application Filing
- 2003-10-14 AT AT03782759T patent/ATE432270T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2540068C (en) | 2012-05-29 |
| CA2540068A1 (en) | 2003-10-14 |
| US20070238885A1 (en) | 2007-10-11 |
| US7566792B2 (en) | 2009-07-28 |
| EP1673361A1 (de) | 2006-06-28 |
| EP1673361B1 (de) | 2009-05-27 |
| WO2005035515A1 (en) | 2005-04-21 |
| AU2003290396A1 (en) | 2005-04-27 |
| ATE432270T1 (de) | 2009-06-15 |
| PT1673361E (pt) | 2009-07-13 |
| ES2325498T3 (es) | 2009-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |