BG100316A - Method for the preparation of lovastatin - Google Patents
Method for the preparation of lovastatinInfo
- Publication number
- BG100316A BG100316A BG100316A BG10031696A BG100316A BG 100316 A BG100316 A BG 100316A BG 100316 A BG100316 A BG 100316A BG 10031696 A BG10031696 A BG 10031696A BG 100316 A BG100316 A BG 100316A
- Authority
- BG
- Bulgaria
- Prior art keywords
- lovastatin
- extracted
- preparation
- lactonized
- sedimented
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The method is used in the pharmaceutical industry. The lovastatin produced has higher purity and yield, and is stable during storage. It is extracted by filtration from the cultural liquor at pH values from 9.5 to 13.0 and is sedimented from the filtrate included in solid mass at pH 2-4 in the presence of inert filler, antioxidant and 0.1-3% organic solvent which does not mix in water. It is extracted and lactonized in chlorine-containing solvent medium. The latter is concentrated and the residue is dissolved in a mixture of solvents of different polarity. In cooling from -10 to -30°C the lovastatin crystallizes. is isolated and is dried.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG100316A BG63011B1 (en) | 1996-01-29 | 1996-01-29 | Method for the preparation of lovastatin |
ES96934242T ES2131037T3 (en) | 1995-12-06 | 1996-10-22 | LOVASTATIN PREPARATION PROCEDURE. |
EA199800522A EA000954B1 (en) | 1995-12-06 | 1996-10-22 | Method of production of lovastatin |
UA98073524A UA44922C2 (en) | 1995-12-06 | 1996-10-22 | METHOD OF OBTAINING LOVASTATIN |
CA002243592A CA2243592C (en) | 1995-12-06 | 1996-10-22 | Method of production of lovastatin |
PCT/BG1996/000013 WO1997020834A1 (en) | 1995-12-06 | 1996-10-22 | Method of production of lovastatin |
AU72716/96A AU7271696A (en) | 1995-12-06 | 1996-10-22 | Method of production of lovastatin |
EP96934242A EP0877742B1 (en) | 1995-12-06 | 1996-10-22 | Method of production of lovastatin |
DE69614571T DE69614571T2 (en) | 1995-12-06 | 1996-10-22 | METHOD FOR PRODUCING LOVASTATIN |
DE0877742T DE877742T1 (en) | 1995-12-06 | 1996-10-22 | METHOD FOR PRODUCING LOVASTATIN |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG100316A BG63011B1 (en) | 1996-01-29 | 1996-01-29 | Method for the preparation of lovastatin |
Publications (2)
Publication Number | Publication Date |
---|---|
BG100316A true BG100316A (en) | 1997-07-31 |
BG63011B1 BG63011B1 (en) | 2001-01-31 |
Family
ID=3926451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG100316A BG63011B1 (en) | 1995-12-06 | 1996-01-29 | Method for the preparation of lovastatin |
Country Status (1)
Country | Link |
---|---|
BG (1) | BG63011B1 (en) |
-
1996
- 1996-01-29 BG BG100316A patent/BG63011B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BG63011B1 (en) | 2001-01-31 |
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