BG100316A - Method for the preparation of lovastatin - Google Patents

Method for the preparation of lovastatin

Info

Publication number
BG100316A
BG100316A BG100316A BG10031696A BG100316A BG 100316 A BG100316 A BG 100316A BG 100316 A BG100316 A BG 100316A BG 10031696 A BG10031696 A BG 10031696A BG 100316 A BG100316 A BG 100316A
Authority
BG
Bulgaria
Prior art keywords
lovastatin
extracted
preparation
lactonized
sedimented
Prior art date
Application number
BG100316A
Other languages
Bulgarian (bg)
Other versions
BG63011B1 (en
Inventor
Димчо ДИМОВ
Неделчо ПЕТКОВ
Георги ГРОЗДАНОВ
Димитра ТОДОРОВА
Original Assignee
"Биовет" Ад
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Биовет" Ад filed Critical "Биовет" Ад
Priority to BG100316A priority Critical patent/BG63011B1/en
Priority to ES96934242T priority patent/ES2131037T3/en
Priority to EA199800522A priority patent/EA000954B1/en
Priority to UA98073524A priority patent/UA44922C2/en
Priority to CA002243592A priority patent/CA2243592C/en
Priority to PCT/BG1996/000013 priority patent/WO1997020834A1/en
Priority to AU72716/96A priority patent/AU7271696A/en
Priority to EP96934242A priority patent/EP0877742B1/en
Priority to DE69614571T priority patent/DE69614571T2/en
Priority to DE0877742T priority patent/DE877742T1/en
Publication of BG100316A publication Critical patent/BG100316A/en
Publication of BG63011B1 publication Critical patent/BG63011B1/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The method is used in the pharmaceutical industry. The lovastatin produced has higher purity and yield, and is stable during storage. It is extracted by filtration from the cultural liquor at pH values from 9.5 to 13.0 and is sedimented from the filtrate included in solid mass at pH 2-4 in the presence of inert filler, antioxidant and 0.1-3% organic solvent which does not mix in water. It is extracted and lactonized in chlorine-containing solvent medium. The latter is concentrated and the residue is dissolved in a mixture of solvents of different polarity. In cooling from -10 to -30°C the lovastatin crystallizes. is isolated and is dried.
BG100316A 1995-12-06 1996-01-29 Method for the preparation of lovastatin BG63011B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BG100316A BG63011B1 (en) 1996-01-29 1996-01-29 Method for the preparation of lovastatin
ES96934242T ES2131037T3 (en) 1995-12-06 1996-10-22 LOVASTATIN PREPARATION PROCEDURE.
EA199800522A EA000954B1 (en) 1995-12-06 1996-10-22 Method of production of lovastatin
UA98073524A UA44922C2 (en) 1995-12-06 1996-10-22 METHOD OF OBTAINING LOVASTATIN
CA002243592A CA2243592C (en) 1995-12-06 1996-10-22 Method of production of lovastatin
PCT/BG1996/000013 WO1997020834A1 (en) 1995-12-06 1996-10-22 Method of production of lovastatin
AU72716/96A AU7271696A (en) 1995-12-06 1996-10-22 Method of production of lovastatin
EP96934242A EP0877742B1 (en) 1995-12-06 1996-10-22 Method of production of lovastatin
DE69614571T DE69614571T2 (en) 1995-12-06 1996-10-22 METHOD FOR PRODUCING LOVASTATIN
DE0877742T DE877742T1 (en) 1995-12-06 1996-10-22 METHOD FOR PRODUCING LOVASTATIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG100316A BG63011B1 (en) 1996-01-29 1996-01-29 Method for the preparation of lovastatin

Publications (2)

Publication Number Publication Date
BG100316A true BG100316A (en) 1997-07-31
BG63011B1 BG63011B1 (en) 2001-01-31

Family

ID=3926451

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100316A BG63011B1 (en) 1995-12-06 1996-01-29 Method for the preparation of lovastatin

Country Status (1)

Country Link
BG (1) BG63011B1 (en)

Also Published As

Publication number Publication date
BG63011B1 (en) 2001-01-31

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