KR890003775A - 결정성 세파드록실 모노하이드레이트의 제조방법 - Google Patents

결정성 세파드록실 모노하이드레이트의 제조방법 Download PDF

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Publication number
KR890003775A
KR890003775A KR1019880000123A KR880000123A KR890003775A KR 890003775 A KR890003775 A KR 890003775A KR 1019880000123 A KR1019880000123 A KR 1019880000123A KR 880000123 A KR880000123 A KR 880000123A KR 890003775 A KR890003775 A KR 890003775A
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KR
South Korea
Prior art keywords
crystalline
monohydrate
solvent compound
cefadroxil
filtration
Prior art date
Application number
KR1019880000123A
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English (en)
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KR960002910B1 (ko
Inventor
레오나르도.마르실리
Original Assignee
니콜라 피에트로 레오나르도
리파르 에스.알.엘.
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Application filed by 니콜라 피에트로 레오나르도, 리파르 에스.알.엘. filed Critical 니콜라 피에트로 레오나르도
Publication of KR890003775A publication Critical patent/KR890003775A/ko
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Publication of KR960002910B1 publication Critical patent/KR960002910B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

결정성 세파드록실 모노하이드레이트의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 세파드록실 용매 화합물을 약 +45℃ 내지 +55℃ 범위의 온도에서 1 내지 2시간 동안 약 6% 내지 약 18중량%의 물을 함유하는 이소프로필 알코올롤 슬러리화시킨 후, 결정성 세파드록실 모노하이드레이트를 여과로 분리함을 특징으로 하여, 결정성 세파드록실 모놔이드레이트를 제조하는 방법.
  2. 제 1 항에 있어서, 언급된 세파드록실 용매 화합물이 공지 기술에 따라 7-ADCA로부터 수득된 세파드록실 수용액의 pH를 5.5 내지 6의 범위로 조정하면서 디메틸아세트아미드, N-메틸-2-피롤리돈 및 모노메틸아미드로 이루어진 그룹중에서 선택된 용매를 가하여 상응하는 세파드록실 용매 화하물을 수득하고, 이를 침전 시키고 여과함으로써 제조된 디메틸아세트아미드, N-메틸-2-피롤리돈 또는 모노메틸 포름아미드의 용매 화합물인 방법.
  3. 제 1 항 또는 제 2 항에 청구된 방법에 따라 제조된 결정성 세파드록실 모노하이드레이트 및 약제학적으로 허용되는 담체 또는 희석제를 함유하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000123A 1987-08-03 1988-01-11 결정성 세파드록실 1수화물의 제조방법 KR960002910B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/080,999 US4898938A (en) 1987-08-03 1987-08-03 Method for preparing crystalline cefadroxil monohydrate
US080,999 1987-08-03
US080999 1987-08-03

Publications (2)

Publication Number Publication Date
KR890003775A true KR890003775A (ko) 1989-04-18
KR960002910B1 KR960002910B1 (ko) 1996-02-28

Family

ID=22161022

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880000123A KR960002910B1 (ko) 1987-08-03 1988-01-11 결정성 세파드록실 1수화물의 제조방법

Country Status (18)

Country Link
US (1) US4898938A (ko)
EP (1) EP0302145B1 (ko)
JP (1) JP2655664B2 (ko)
KR (1) KR960002910B1 (ko)
CN (1) CN1016607B (ko)
AT (1) ATE105560T1 (ko)
AU (1) AU597136B2 (ko)
CA (1) CA1285554C (ko)
DE (1) DE3789810T2 (ko)
DK (1) DK680387A (ko)
ES (1) ES2056059T3 (ko)
FI (1) FI88043C (ko)
NO (1) NO168425C (ko)
PH (1) PH23648A (ko)
PT (1) PT86526B (ko)
RU (1) RU1804461C (ko)
YU (1) YU44649B (ko)
ZA (1) ZA879701B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023560A6 (es) * 1989-07-10 1992-01-16 Gema Sa Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
US5589593A (en) * 1991-11-11 1996-12-31 Biochimica Opos Spa Crystalline form of a cephalosporin antibiotic
IT1251999B (it) * 1991-11-11 1995-05-27 Opos Biochimica Srl Forma cristallina di un antibiotico cefalosporinico
WO2003092626A2 (en) * 2002-05-03 2003-11-13 Smithkline Beecham Pharmco Puerto Rico, Inc. Carvedilol pharmasolve solvate
US20040077849A1 (en) * 2002-10-16 2004-04-22 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefadroxil
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
CN1311830C (zh) * 2004-02-27 2007-04-25 石药集团中奇制药技术（石家庄）有限公司 头孢羟氨苄口腔崩解片及其制备方法
CN102351884B (zh) * 2006-05-19 2015-06-17 中化帝斯曼制药有限公司荷兰公司 一种用于结晶头孢羟氨苄的方法
CN102134250B (zh) * 2011-01-19 2013-03-13 天津大学 一种头孢羟氨苄单水合物的结晶方法及结晶
CN104447795B (zh) * 2014-11-28 2016-08-17 珠海金鸿药业股份有限公司 一种头孢羟氨苄化合物及其药物组合物
CN105534937B (zh) * 2015-12-30 2019-12-03 石药集团欧意药业有限公司 一种头孢羟氨苄片剂及其制备方法
CN106588953B (zh) * 2016-11-08 2018-11-27 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物头孢羟氨苄晶型化合物及其组合物
CN106588954B (zh) * 2016-11-08 2018-11-27 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物羟氨苄晶体化合物及其组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
GB8714180D0 (en) * 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
WO1988008320A1 (en) * 1987-04-24 1988-11-03 Invenmark Limited Puzzle

Also Published As

Publication number Publication date
FI881040A (fi) 1989-02-04
JP2655664B2 (ja) 1997-09-24
ATE105560T1 (de) 1994-05-15
ES2056059T3 (es) 1994-10-01
AU8304587A (en) 1989-02-09
CN1016607B (zh) 1992-05-13
YU242787A (en) 1989-02-28
DE3789810D1 (de) 1994-06-16
DK680387D0 (da) 1987-12-22
JPS6442487A (en) 1989-02-14
EP0302145A3 (en) 1989-08-23
YU44649B (en) 1990-10-31
FI881040A0 (fi) 1988-03-07
NO880026D0 (no) 1988-01-05
EP0302145A2 (en) 1989-02-08
AU597136B2 (en) 1990-05-24
DE3789810T2 (de) 1994-08-18
ZA879701B (en) 1988-06-23
EP0302145B1 (en) 1994-05-11
KR960002910B1 (ko) 1996-02-28
NO168425B (no) 1991-11-11
DK680387A (da) 1989-02-04
FI88043C (fi) 1993-03-25
CN1031085A (zh) 1989-02-15
CA1285554C (en) 1991-07-02
NO168425C (no) 1992-02-19
FI88043B (fi) 1992-12-15
PT86526B (pt) 1994-10-31
NO880026L (no) 1989-02-06
RU1804461C (ru) 1993-03-23
PT86526A (pt) 1989-09-14
PH23648A (en) 1989-09-27
US4898938A (en) 1990-02-06

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