KR890003775A - 결정성 세파드록실 모노하이드레이트의 제조방법 - Google Patents
결정성 세파드록실 모노하이드레이트의 제조방법 Download PDFInfo
- Publication number
- KR890003775A KR890003775A KR1019880000123A KR880000123A KR890003775A KR 890003775 A KR890003775 A KR 890003775A KR 1019880000123 A KR1019880000123 A KR 1019880000123A KR 880000123 A KR880000123 A KR 880000123A KR 890003775 A KR890003775 A KR 890003775A
- Authority
- KR
- South Korea
- Prior art keywords
- crystalline
- monohydrate
- solvent compound
- cefadroxil
- filtration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 세파드록실 용매 화합물을 약 +45℃ 내지 +55℃ 범위의 온도에서 1 내지 2시간 동안 약 6% 내지 약 18중량%의 물을 함유하는 이소프로필 알코올롤 슬러리화시킨 후, 결정성 세파드록실 모노하이드레이트를 여과로 분리함을 특징으로 하여, 결정성 세파드록실 모놔이드레이트를 제조하는 방법.
- 제 1 항에 있어서, 언급된 세파드록실 용매 화합물이 공지 기술에 따라 7-ADCA로부터 수득된 세파드록실 수용액의 pH를 5.5 내지 6의 범위로 조정하면서 디메틸아세트아미드, N-메틸-2-피롤리돈 및 모노메틸아미드로 이루어진 그룹중에서 선택된 용매를 가하여 상응하는 세파드록실 용매 화하물을 수득하고, 이를 침전 시키고 여과함으로써 제조된 디메틸아세트아미드, N-메틸-2-피롤리돈 또는 모노메틸 포름아미드의 용매 화합물인 방법.
- 제 1 항 또는 제 2 항에 청구된 방법에 따라 제조된 결정성 세파드록실 모노하이드레이트 및 약제학적으로 허용되는 담체 또는 희석제를 함유하는 약제학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US080,999 | 1987-08-03 | ||
US07/080,999 US4898938A (en) | 1987-08-03 | 1987-08-03 | Method for preparing crystalline cefadroxil monohydrate |
US080999 | 1987-08-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890003775A true KR890003775A (ko) | 1989-04-18 |
KR960002910B1 KR960002910B1 (ko) | 1996-02-28 |
Family
ID=22161022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880000123A KR960002910B1 (ko) | 1987-08-03 | 1988-01-11 | 결정성 세파드록실 1수화물의 제조방법 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4898938A (ko) |
EP (1) | EP0302145B1 (ko) |
JP (1) | JP2655664B2 (ko) |
KR (1) | KR960002910B1 (ko) |
CN (1) | CN1016607B (ko) |
AT (1) | ATE105560T1 (ko) |
AU (1) | AU597136B2 (ko) |
CA (1) | CA1285554C (ko) |
DE (1) | DE3789810T2 (ko) |
DK (1) | DK680387A (ko) |
ES (1) | ES2056059T3 (ko) |
FI (1) | FI88043C (ko) |
NO (1) | NO168425C (ko) |
PH (1) | PH23648A (ko) |
PT (1) | PT86526B (ko) |
RU (1) | RU1804461C (ko) |
YU (1) | YU44649B (ko) |
ZA (1) | ZA879701B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69013305T2 (de) * | 1989-07-10 | 1995-05-18 | Chemferm Vof | Stabile form von cephradin, verfahren zu dessen herstellung und darin verwendete zwischenprodukte. |
IT1251999B (it) * | 1991-11-11 | 1995-05-27 | Opos Biochimica Srl | Forma cristallina di un antibiotico cefalosporinico |
US5589593A (en) * | 1991-11-11 | 1996-12-31 | Biochimica Opos Spa | Crystalline form of a cephalosporin antibiotic |
CA2484624A1 (en) * | 2002-05-03 | 2003-11-13 | Smithkline Beecham Pharmco Puerto Rico, Inc. | Carvedilol pharmasolve solvate |
US20040077849A1 (en) * | 2002-10-16 | 2004-04-22 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefadroxil |
US7842791B2 (en) * | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
CN1311830C (zh) * | 2004-02-27 | 2007-04-25 | 石药集团中奇制药技术(石家庄)有限公司 | 头孢羟氨苄口腔崩解片及其制备方法 |
MX2008014711A (es) * | 2006-05-19 | 2008-12-03 | Dsm Ip Assets Bv | Procedimiento para la cristalizacion de cefadroxilo. |
CN102134250B (zh) * | 2011-01-19 | 2013-03-13 | 天津大学 | 一种头孢羟氨苄单水合物的结晶方法及结晶 |
CN104447795B (zh) * | 2014-11-28 | 2016-08-17 | 珠海金鸿药业股份有限公司 | 一种头孢羟氨苄化合物及其药物组合物 |
CN105534937B (zh) * | 2015-12-30 | 2019-12-03 | 石药集团欧意药业有限公司 | 一种头孢羟氨苄片剂及其制备方法 |
CN106588954B (zh) * | 2016-11-08 | 2018-11-27 | 山东罗欣药业集团恒欣药业有限公司 | 一种抗感染药物羟氨苄晶体化合物及其组合物 |
CN106588953B (zh) * | 2016-11-08 | 2018-11-27 | 山东罗欣药业集团恒欣药业有限公司 | 一种抗感染药物头孢羟氨苄晶型化合物及其组合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1532682A (en) * | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
US4160863A (en) * | 1977-04-07 | 1979-07-10 | Bristol-Myers Company | Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid |
GB8714180D0 (en) * | 1987-06-17 | 1987-07-22 | Rifar Srl | Anhydrous crystalline cefadroxil |
AU1628588A (en) * | 1987-04-24 | 1988-12-02 | Invenmark Limited | Puzzle |
-
1987
- 1987-08-03 US US07/080,999 patent/US4898938A/en not_active Expired - Fee Related
- 1987-12-22 DK DK680387A patent/DK680387A/da not_active Application Discontinuation
- 1987-12-22 DE DE3789810T patent/DE3789810T2/de not_active Expired - Fee Related
- 1987-12-22 EP EP87119079A patent/EP0302145B1/en not_active Expired - Lifetime
- 1987-12-22 AT AT8787119079T patent/ATE105560T1/de not_active IP Right Cessation
- 1987-12-22 ES ES87119079T patent/ES2056059T3/es not_active Expired - Lifetime
- 1987-12-24 AU AU83045/87A patent/AU597136B2/en not_active Ceased
- 1987-12-28 ZA ZA879701A patent/ZA879701B/xx unknown
- 1987-12-29 YU YU2427/87A patent/YU44649B/xx unknown
- 1987-12-30 CA CA000555571A patent/CA1285554C/en not_active Expired - Lifetime
-
1988
- 1988-01-05 NO NO880026A patent/NO168425C/no unknown
- 1988-01-11 KR KR1019880000123A patent/KR960002910B1/ko not_active IP Right Cessation
- 1988-01-11 PT PT86526A patent/PT86526B/pt not_active IP Right Cessation
- 1988-01-18 RU SU884204000A patent/RU1804461C/ru active
- 1988-02-04 JP JP63024868A patent/JP2655664B2/ja not_active Expired - Lifetime
- 1988-02-10 CN CN88100573A patent/CN1016607B/zh not_active Expired
- 1988-03-07 FI FI881040A patent/FI88043C/fi not_active IP Right Cessation
- 1988-04-04 PH PH36730A patent/PH23648A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA1285554C (en) | 1991-07-02 |
EP0302145A2 (en) | 1989-02-08 |
FI88043C (fi) | 1993-03-25 |
NO880026D0 (no) | 1988-01-05 |
CN1031085A (zh) | 1989-02-15 |
DK680387D0 (da) | 1987-12-22 |
DE3789810D1 (de) | 1994-06-16 |
JPS6442487A (en) | 1989-02-14 |
ATE105560T1 (de) | 1994-05-15 |
FI881040A (fi) | 1989-02-04 |
DE3789810T2 (de) | 1994-08-18 |
DK680387A (da) | 1989-02-04 |
PT86526A (pt) | 1989-09-14 |
RU1804461C (ru) | 1993-03-23 |
PT86526B (pt) | 1994-10-31 |
ES2056059T3 (es) | 1994-10-01 |
NO168425C (no) | 1992-02-19 |
AU597136B2 (en) | 1990-05-24 |
JP2655664B2 (ja) | 1997-09-24 |
YU242787A (en) | 1989-02-28 |
KR960002910B1 (ko) | 1996-02-28 |
FI88043B (fi) | 1992-12-15 |
NO880026L (no) | 1989-02-06 |
CN1016607B (zh) | 1992-05-13 |
ZA879701B (en) | 1988-06-23 |
FI881040A0 (fi) | 1988-03-07 |
YU44649B (en) | 1990-10-31 |
AU8304587A (en) | 1989-02-09 |
EP0302145A3 (en) | 1989-08-23 |
EP0302145B1 (en) | 1994-05-11 |
US4898938A (en) | 1990-02-06 |
NO168425B (no) | 1991-11-11 |
PH23648A (en) | 1989-09-27 |
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Legal Events
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |