KR890000496A - 무수 결정형 세파드록실 및 이의 제조방법 - Google Patents
무수 결정형 세파드록실 및 이의 제조방법 Download PDFInfo
- Publication number
- KR890000496A KR890000496A KR1019880000124A KR880000124A KR890000496A KR 890000496 A KR890000496 A KR 890000496A KR 1019880000124 A KR1019880000124 A KR 1019880000124A KR 880000124 A KR880000124 A KR 880000124A KR 890000496 A KR890000496 A KR 890000496A
- Authority
- KR
- South Korea
- Prior art keywords
- cepadroxyl
- water
- anhydrous crystalline
- substantially anhydrous
- cefadroxil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 함수량이 약 0.8% 내지 약 3.9%이고 하기 X-선 회절 특성을 갖는 실질적인 무수 결정형 세파드록실 :
- 7-ADCA로부터 바로 제조된 세파드록실 수용액의 pH를 5.5 내지 6으로 조절하면서 이 용액에 디메틸아세트아미드, N-메틸-2-피롤리돈, 모노메틸 포름아미드로 구성된 그룹으로부터 선택된 용매를 가하여 이에 상응하는 세파드록실 용매화물을 침전시키고 이를 여과하여, 건조시킨 후 약 2% 내지 4% 물 또는, 약 0.1% 내지 4% 물 및 0% 내지 약 60% 메탄올을 함유하는 이소프로필 알코올로 +45℃ 내지 +55℃ 온도에서 슬러리화하고, 목적하는 세파드록실을 여과하여 분리하여, 제 1 항에 따른 결정형 세파드록실을 제조하는 방법.
- 제 1 항에서 청구되거나, 또는 제 2 항에서 청구한 방법으로 생성된 실질적인 무수 결정형 세파드록실 및 약제학적으로 허용되는 담체 또는 희석제를 함유하는 약제학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8714180 | 1987-06-17 | ||
GB878714180A GB8714180D0 (en) | 1987-06-17 | 1987-06-17 | Anhydrous crystalline cefadroxil |
US07/825,737 US5329001A (en) | 1987-06-17 | 1992-01-27 | Substantially anhydrous crystalline cefadroxil and method for producing it |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890000496A true KR890000496A (ko) | 1989-03-15 |
KR950011744B1 KR950011744B1 (ko) | 1995-10-09 |
Family
ID=26292369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880000124A KR950011744B1 (ko) | 1986-06-17 | 1988-01-11 | 무수 결정형 세파드록실 및 이의 제조방법 |
Country Status (21)
Country | Link |
---|---|
US (1) | US5329001A (ko) |
EP (1) | EP0295333B1 (ko) |
JP (1) | JPS63316785A (ko) |
KR (1) | KR950011744B1 (ko) |
CN (1) | CN1022922C (ko) |
AT (1) | ATE78257T1 (ko) |
AU (1) | AU595410B2 (ko) |
CA (1) | CA1339213C (ko) |
DE (1) | DE3780454T2 (ko) |
DK (1) | DK680487A (ko) |
ES (1) | ES2051724T3 (ko) |
FI (1) | FI87787C (ko) |
GB (1) | GB8714180D0 (ko) |
GR (1) | GR3005733T3 (ko) |
HK (1) | HK32793A (ko) |
NO (1) | NO168360C (ko) |
PH (1) | PH24594A (ko) |
PT (1) | PT86525B (ko) |
SU (1) | SU1595340A3 (ko) |
YU (1) | YU44650B (ko) |
ZA (1) | ZA879700B (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4898938A (en) * | 1987-08-03 | 1990-02-06 | Rifar S.R.L. | Method for preparing crystalline cefadroxil monohydrate |
PL369406A1 (en) | 2001-10-24 | 2005-04-18 | Sepracor Inc. | Method of resolving amlodipine racemate |
US20040077849A1 (en) * | 2002-10-16 | 2004-04-22 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefadroxil |
CN1311830C (zh) * | 2004-02-27 | 2007-04-25 | 石药集团中奇制药技术(石家庄)有限公司 | 头孢羟氨苄口腔崩解片及其制备方法 |
BRPI0711924B1 (pt) | 2006-05-19 | 2023-11-28 | Centrient Pharmaceuticals Netherlands B.V. | Processo para a preparação de cefadroxil monoidratado em forma de cristal |
CN102134250B (zh) * | 2011-01-19 | 2013-03-13 | 天津大学 | 一种头孢羟氨苄单水合物的结晶方法及结晶 |
CN105534937B (zh) * | 2015-12-30 | 2019-12-03 | 石药集团欧意药业有限公司 | 一种头孢羟氨苄片剂及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2163514A1 (de) * | 1971-12-21 | 1973-07-05 | Toyama Chemical Co Ltd | Verfahren zur herstellung von cephalosporinen |
BE793191A (fr) * | 1971-12-28 | 1973-06-22 | Toyama Chemical Co Ltd | Procede pour produire des acides 7-acylamido-3-cephem-4- carboxyliques |
US3985741A (en) * | 1972-09-15 | 1976-10-12 | Bristol-Myers Company | Production of p-hydroxycephalexin |
GB1532682A (en) * | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
DE3313818A1 (de) * | 1983-04-16 | 1984-10-18 | Hoechst Ag, 6230 Frankfurt | Neue kristallmodifikation von ceftazidim |
JPS60231683A (ja) * | 1984-05-02 | 1985-11-18 | Teijin Ltd | セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤 |
US4904776A (en) * | 1987-04-24 | 1990-02-27 | Rifar S.R.L. | Method for producing crystalline cefadroxil hemihydrate |
-
1987
- 1987-06-17 GB GB878714180A patent/GB8714180D0/en active Pending
- 1987-11-23 ES ES87117225T patent/ES2051724T3/es not_active Expired - Lifetime
- 1987-11-23 DE DE8787117225T patent/DE3780454T2/de not_active Expired - Lifetime
- 1987-11-23 EP EP87117225A patent/EP0295333B1/en not_active Expired - Lifetime
- 1987-11-23 AT AT87117225T patent/ATE78257T1/de not_active IP Right Cessation
- 1987-12-22 DK DK680487A patent/DK680487A/da not_active Application Discontinuation
- 1987-12-24 AU AU83041/87A patent/AU595410B2/en not_active Ceased
- 1987-12-28 ZA ZA879700A patent/ZA879700B/xx unknown
- 1987-12-29 CA CA000555491A patent/CA1339213C/en not_active Expired - Fee Related
- 1987-12-29 YU YU2428/87A patent/YU44650B/xx unknown
-
1988
- 1988-01-05 NO NO880027A patent/NO168360C/no unknown
- 1988-01-11 PT PT86525A patent/PT86525B/pt not_active IP Right Cessation
- 1988-01-11 KR KR1019880000124A patent/KR950011744B1/ko not_active IP Right Cessation
- 1988-01-25 SU SU884355130A patent/SU1595340A3/ru active
- 1988-02-04 JP JP63024867A patent/JPS63316785A/ja active Pending
- 1988-02-10 CN CN88100566A patent/CN1022922C/zh not_active Expired - Fee Related
- 1988-03-07 FI FI881039A patent/FI87787C/fi not_active IP Right Cessation
- 1988-04-04 PH PH36728A patent/PH24594A/en unknown
-
1992
- 1992-01-27 US US07/825,737 patent/US5329001A/en not_active Expired - Fee Related
- 1992-09-17 GR GR920402056T patent/GR3005733T3/el unknown
-
1993
- 1993-04-01 HK HK327/93A patent/HK32793A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI87787C (fi) | 1993-02-25 |
EP0295333A2 (en) | 1988-12-21 |
PT86525B (pt) | 1992-07-31 |
ZA879700B (ko) | 1988-06-23 |
YU44650B (en) | 1990-10-31 |
NO880027D0 (no) | 1988-01-05 |
CN88100566A (zh) | 1988-12-28 |
DK680487D0 (da) | 1987-12-22 |
PH24594A (en) | 1990-08-17 |
KR950011744B1 (ko) | 1995-10-09 |
FI87787B (fi) | 1992-11-13 |
GB8714180D0 (en) | 1987-07-22 |
AU8304187A (en) | 1988-12-22 |
ES2051724T3 (es) | 1994-07-01 |
DE3780454T2 (de) | 1992-12-17 |
CA1339213C (en) | 1997-08-05 |
NO168360C (no) | 1992-02-12 |
NO168360B (no) | 1991-11-04 |
CN1022922C (zh) | 1993-12-01 |
US5329001A (en) | 1994-07-12 |
FI881039A (fi) | 1988-12-18 |
AU595410B2 (en) | 1990-03-29 |
ATE78257T1 (de) | 1992-08-15 |
SU1595340A3 (ru) | 1990-09-23 |
HK32793A (en) | 1993-04-08 |
DK680487A (da) | 1988-12-18 |
FI881039A0 (fi) | 1988-03-07 |
JPS63316785A (ja) | 1988-12-26 |
PT86525A (en) | 1989-05-31 |
EP0295333A3 (en) | 1989-10-18 |
GR3005733T3 (ko) | 1993-06-07 |
YU242887A (en) | 1988-12-31 |
NO880027L (no) | 1988-12-19 |
EP0295333B1 (en) | 1992-07-15 |
DE3780454D1 (de) | 1992-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |