KR870002076A - 토라세미드 안정변형체의 제조방법 및 그의 약제 조성물 - Google Patents

토라세미드 안정변형체의 제조방법 및 그의 약제 조성물 Download PDF

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Publication number
KR870002076A
KR870002076A KR1019860006689A KR860006689A KR870002076A KR 870002076 A KR870002076 A KR 870002076A KR 1019860006689 A KR1019860006689 A KR 1019860006689A KR 860006689 A KR860006689 A KR 860006689A KR 870002076 A KR870002076 A KR 870002076A
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South Korea
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variant
torasemide
pharmaceutical composition
rearrangement
space group
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KR1019860006689A
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KR930009818B1 (ko
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토프메이어 프리쯔
레텐바우어 구스타브
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마틴다움
뵈링거 만하임 게엠베하
허버트 포우퀘트
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Publication of KR870002076A publication Critical patent/KR870002076A/ko
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Publication of KR930009818B1 publication Critical patent/KR930009818B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

토라세미드 안정변형체의 제조방법 및 그의 약제 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 토라세미드 변형체(Ⅱ)의 부유물을 물에서 재배열이 끝날때까지 변형체(I)의 촉매적 양을 첨가하며 교반시켜, 코라세미드 변형체(Ⅱ)(단사적, 스페이스그룹 P2/n, 녹는점 169℃)로 부터 순수 변형체(I)(단사적, 스페이스그룹 P21/C, 녹는점 162℃)의 결정 토라세미드 제조방법.
  2. 제1항에 있어서, 재배열은 실온 내지 90℃에서 수행되며 재배열 시간은 14일 내지 3시간임을 특징으로 하는 방법.
  3. 제1항 또는 2항에 있어서, 토라세미드 변형체(Ⅱ)는 염이 함유된 형태, 알칼리용액으로 부터 토라세미드 침전에 의해 얻어진 중성에 가까운 용액의 형태로 사용됨을 특징으로 하는 방법.
  4. 제1항 내지 4항중 어느 한항에 있어서, 결정성 토라세미드 변형체(I)의 제조방법.
  5. 약학적으로 수용할 수 있는 운반체와 혼합시킨 토라세미드 변형체(I)가 함유된 약제 조성물.
  6. 순수 변형체(I)(단사적, 스페이스그룹 P21/C, 녹는점 162℃) 및 약학적으로 수용할 수 있는 운반체로 부터 제조된 약제 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860006689A 1985-08-17 1986-08-14 토라세미드 안정변형체의 제조방법 및 그의 약제 조성물 KR930009818B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19853529529 DE3529529A1 (de) 1985-08-17 1985-08-17 Verfahren zur herstellung einer stabilen modifikation von torasemid
DE3529529.5 1985-08-17
DEP3529529.5 1985-08-17

Publications (2)

Publication Number Publication Date
KR870002076A true KR870002076A (ko) 1987-03-30
KR930009818B1 KR930009818B1 (ko) 1993-10-11

Family

ID=6278766

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860006689A KR930009818B1 (ko) 1985-08-17 1986-08-14 토라세미드 안정변형체의 제조방법 및 그의 약제 조성물

Country Status (25)

Country Link
US (4) US4743693A (ko)
EP (1) EP0212537B1 (ko)
JP (2) JPS6245576A (ko)
KR (1) KR930009818B1 (ko)
AU (1) AU573454B2 (ko)
CA (1) CA1307277C (ko)
CS (2) CS259891B2 (ko)
DD (1) DD259858A5 (ko)
DE (2) DE3529529A1 (ko)
DK (1) DK162518C (ko)
ES (1) ES2001522A6 (ko)
FI (1) FI82189C (ko)
GR (1) GR862139B (ko)
HK (1) HK59994A (ko)
HU (1) HU195778B (ko)
IE (1) IE59237B1 (ko)
IL (1) IL79672A (ko)
LT (1) LT3596B (ko)
NO (1) NO170079C (ko)
NZ (1) NZ217172A (ko)
PL (1) PL146086B1 (ko)
PT (1) PT83186B (ko)
SU (1) SU1480766A3 (ko)
UA (1) UA7080A1 (ko)
ZA (1) ZA866151B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623620A1 (de) * 1986-07-12 1988-01-21 Boehringer Mannheim Gmbh Spritzfertige, waessrige, alkalische injektionsloesungen von torasemid und verfahren zu ihrer herstellung
US5166162A (en) * 1990-03-02 1992-11-24 Adir Et Compagnie Pyridylsulfonylurea and pyridylsulfonylthiourea compounds
JP3586471B2 (ja) * 1991-06-25 2004-11-10 三菱ウェルファーマ株式会社 トラセミド含有医薬組成物
HRP980532B1 (en) * 1998-10-02 2005-06-30 Pliva Novel crystalline torasemide modification
US6166045A (en) 1998-06-02 2000-12-26 Roche Diagnostics Gmbh Torasemide of modification III
US5914336A (en) 1998-06-02 1999-06-22 Boehringer Mannheim Gmbh Method of controlling the serum solubility of orally administered torasemide and composition relating thereto
US20030026835A1 (en) * 1999-02-15 2003-02-06 Sumitomo Pharmaceuticals Company Limited Tablets disintegrating rapidly in the oral cavity
TR200200353T2 (tr) 1999-08-11 2002-06-21 Teva Pharmaceutical Industries Ltd. Torsemid Polimorfları
CN1505512A (zh) 2000-02-17 2004-06-16 ������ҩ��ҵ���޹�˾ 包含托塞米变型ⅱ的稳定药物制剂
AU2001247592B2 (en) 2000-03-20 2005-08-18 Teva Pharmaceutical Industries Ltd. Novel processes for preparing torsemide intermediate
HRP20000162B1 (en) * 2000-03-20 2004-06-30 Pliva D D Amorphous torasemide modification
HRP20000765A2 (en) * 2000-11-10 2002-06-30 Pliva D D Compositions of n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridylsulfonamide and cyclic oligosaccharides with increased release
US20030022921A1 (en) * 2001-02-21 2003-01-30 Minutza Leibovici Stable pharmaceutical formulation comprising torsemide modification II
IN192178B (ko) * 2001-08-03 2004-03-06 Ranbaxy Lab
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
ITMI20020639A1 (it) * 2002-03-27 2003-09-29 Cosma S P A Composizioni farmaceutiche comprendenti come principio attivo 1-isopropil-3°(4-m-toluidino-3-pridil)sulfonil!-urea
HRP20020603B1 (en) * 2002-07-19 2008-11-30 Pliva D.D. New process for the preparation of modification i n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide
KR20050075424A (ko) * 2002-11-18 2005-07-20 테바 파마슈티컬 인더스트리즈 리미티드 500 ｐｐｍ을 초과하고 약 3,000 ｐｐｍ 이하인 물과 200ｐｐｍ을 초과하고 약 5,000 ｐｐｍ 이하인 알콜을함유하는 안정한 란소프라졸
EP1485373A1 (en) * 2003-02-05 2004-12-15 Teva Pharmaceutical Industries Limited Method of stabilizing lansoprazole
ES2244324B1 (es) * 2004-03-25 2006-11-16 Ferrer Internacional, S.A. Composiciones diureticas de liberacion prolongada.
AT500576B1 (de) * 2004-07-28 2006-11-15 Sanochemia Pharmazeutika Ag Verfahren zur reindarstellung von kristallformen von torsemid
US10178893B1 (en) * 2013-06-14 2019-01-15 Scott Bradley Baker Shoe
FR3018688A1 (fr) * 2014-03-19 2015-09-25 Virbac Utilisation de torasemide a faible dose dans une composition veterinaire
EP3031471A1 (en) * 2014-12-12 2016-06-15 Ceva Sante Animale Veterinary composition for the treatment of pulmonary edema associated with heart failure in domestic animals
SI3173075T1 (sl) * 2015-11-27 2019-02-28 Accupharma Spolka Z Ograniczona Odpowiedzialnoscia Farmacevtski kombinacijski pripravek inhibitorja ACE in diuretika zanke
CN115417810B (zh) * 2022-09-22 2023-10-10 南京正科医药股份有限公司 一种托拉塞米晶型ⅰ的精制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30633A (en) * 1860-11-13 Improvement in fire-escapes
GB1477664A (en) * 1974-04-17 1977-06-22 Christiaens Sa A Pyridine derivatives
GB1593609A (en) * 1978-01-31 1981-07-22 Christiaens Sa A Pyridine sulfonamides
LU85193A1 (fr) * 1984-01-31 1985-09-12 Christiaens Sa A Nouveaux derives de la 4-phenylaminopyridine,leur utilisation et leur preparation

Also Published As

Publication number Publication date
IE59237B1 (en) 1994-01-26
IL79672A0 (en) 1986-11-30
DE3529529A1 (de) 1987-02-19
HU195778B (en) 1988-07-28
HK59994A (en) 1994-07-08
NO170079B (no) 1992-06-01
FI82189C (fi) 1991-02-11
FI863305A (fi) 1987-02-18
EP0212537A1 (de) 1987-03-04
DD259858A5 (de) 1988-09-07
CS259891B2 (en) 1988-11-15
DK385586D0 (da) 1986-08-13
KR930009818B1 (ko) 1993-10-11
PT83186A (de) 1986-09-01
AU573454B2 (en) 1988-06-09
LTIP898A (en) 1995-03-27
DE3667970D1 (de) 1990-02-08
CS419991A3 (en) 1992-06-17
US4743693A (en) 1988-05-10
NO863305D0 (no) 1986-08-15
HUT42069A (en) 1987-06-29
JPH0415205B2 (ko) 1992-03-17
US4822807A (en) 1989-04-18
NO863305L (no) 1987-02-18
NZ217172A (en) 1989-02-24
NO170079C (no) 1992-09-09
UA7080A1 (uk) 1995-06-30
PL146086B1 (en) 1988-12-31
AU6105586A (en) 1987-02-19
FI82189B (fi) 1990-10-31
PL261052A1 (en) 1987-11-02
DK385586A (da) 1987-02-18
DE3529529C2 (ko) 1987-05-27
DK162518B (da) 1991-11-11
FI863305A0 (fi) 1986-08-15
JPS6245576A (ja) 1987-02-27
USRE34672E (en) 1994-07-26
JPH0643400B2 (ja) 1994-06-08
GR862139B (en) 1986-12-30
SU1480766A3 (ru) 1989-05-15
CS594586A2 (en) 1988-03-15
JPH02191255A (ja) 1990-07-27
EP0212537B1 (de) 1990-01-03
PT83186B (pt) 1988-07-01
LT3596B (en) 1995-12-27
DK162518C (da) 1992-03-30
IL79672A (en) 1990-01-18
ZA866151B (en) 1987-04-29
IE862179L (en) 1987-02-17
CA1307277C (en) 1992-09-08
USRE34580E (en) 1994-04-05
ES2001522A6 (es) 1988-06-01

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