DE69614571D1 - Verfahren zur herstellung von lovastatin - Google Patents
Verfahren zur herstellung von lovastatinInfo
- Publication number
- DE69614571D1 DE69614571D1 DE69614571T DE69614571T DE69614571D1 DE 69614571 D1 DE69614571 D1 DE 69614571D1 DE 69614571 T DE69614571 T DE 69614571T DE 69614571 T DE69614571 T DE 69614571T DE 69614571 D1 DE69614571 D1 DE 69614571D1
- Authority
- DE
- Germany
- Prior art keywords
- producing lovastatin
- lovastatin
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG100197A BG62651B1 (bg) | 1995-12-06 | 1995-12-06 | Метод за изолиране и пречистване на ловастатин |
BG100316A BG63011B1 (bg) | 1996-01-29 | 1996-01-29 | метод за получаване на ловастатин |
PCT/BG1996/000013 WO1997020834A1 (en) | 1995-12-06 | 1996-10-22 | Method of production of lovastatin |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69614571D1 true DE69614571D1 (de) | 2001-09-20 |
DE69614571T2 DE69614571T2 (de) | 2002-06-27 |
Family
ID=25663364
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0877742T Pending DE877742T1 (de) | 1995-12-06 | 1996-10-22 | Verfahren zur herstellung von lovastatin |
DE69614571T Expired - Fee Related DE69614571T2 (de) | 1995-12-06 | 1996-10-22 | Verfahren zur herstellung von lovastatin |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0877742T Pending DE877742T1 (de) | 1995-12-06 | 1996-10-22 | Verfahren zur herstellung von lovastatin |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0877742B1 (de) |
AU (1) | AU7271696A (de) |
CA (1) | CA2243592C (de) |
DE (2) | DE877742T1 (de) |
EA (1) | EA000954B1 (de) |
ES (1) | ES2131037T3 (de) |
UA (1) | UA44922C2 (de) |
WO (1) | WO1997020834A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9800046A (sl) * | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
DE69922348T2 (de) * | 1998-12-10 | 2005-12-01 | Kaneka Corp. | Verfahren zur herstellung eines simvastatin precursors |
SK282679B6 (sk) * | 1999-04-16 | 2002-11-06 | Biotika, A. S. | Spôsob izolácie lovastatínu z vyfermentovanej pôdy |
JP2003525935A (ja) | 2000-03-03 | 2003-09-02 | ビオガル ジョジセルジャール アール テー. | 低下したレベルの二量体不純物を伴うロバスタチン及びシンバスタチンの精製方法 |
IN192861B (de) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
ES2204285B1 (es) * | 2002-05-20 | 2005-03-01 | Ercros Industrial, S.A. | Procedimiento para el aislamiento y purificacion de lovastatina. |
US7566792B2 (en) | 2003-10-14 | 2009-07-28 | Lupin Limited | Method for the manufacture of Lovastatin |
ATE414071T1 (de) | 2004-03-30 | 2008-11-15 | Lupin Ltd | Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten |
WO2009013764A2 (en) * | 2007-07-24 | 2009-01-29 | Jubilant Organosys Limited | Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one |
CN103012344B (zh) * | 2011-09-28 | 2014-11-12 | 北大方正集团有限公司 | 从洛伐他汀结晶母液中回收洛伐他汀的方法 |
EP2597092A1 (de) | 2011-11-24 | 2013-05-29 | Sterling Biotech Limited | Verfahren zum Reinigen von Lovastatin |
CN102875505B (zh) * | 2012-08-02 | 2015-08-05 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
CN106083789A (zh) * | 2016-06-07 | 2016-11-09 | 山东鲁抗医药股份有限公司 | 从发酵液中沉淀分离提取洛伐他汀的方法 |
CN108976190B (zh) * | 2017-12-21 | 2020-09-04 | 北大方正集团有限公司 | 一种从洛伐他汀结晶母液中回收洛伐他汀的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
-
1996
- 1996-10-22 EP EP96934242A patent/EP0877742B1/de not_active Expired - Lifetime
- 1996-10-22 DE DE0877742T patent/DE877742T1/de active Pending
- 1996-10-22 CA CA002243592A patent/CA2243592C/en not_active Expired - Fee Related
- 1996-10-22 AU AU72716/96A patent/AU7271696A/en not_active Abandoned
- 1996-10-22 WO PCT/BG1996/000013 patent/WO1997020834A1/en active IP Right Grant
- 1996-10-22 EA EA199800522A patent/EA000954B1/ru not_active IP Right Cessation
- 1996-10-22 ES ES96934242T patent/ES2131037T3/es not_active Expired - Lifetime
- 1996-10-22 UA UA98073524A patent/UA44922C2/uk unknown
- 1996-10-22 DE DE69614571T patent/DE69614571T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2131037T1 (es) | 1999-07-16 |
AU7271696A (en) | 1997-06-27 |
EP0877742B1 (de) | 2001-08-16 |
EA000954B1 (ru) | 2000-08-28 |
UA44922C2 (uk) | 2002-03-15 |
CA2243592C (en) | 2001-12-25 |
ES2131037T3 (es) | 2001-12-16 |
EA199800522A1 (ru) | 1999-02-25 |
DE69614571T2 (de) | 2002-06-27 |
CA2243592A1 (en) | 1997-06-12 |
EP0877742A1 (de) | 1998-11-18 |
WO1997020834A1 (en) | 1997-06-12 |
DE877742T1 (de) | 1999-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |