ATE414071T1 - Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten - Google Patents

Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten

Info

Publication number
ATE414071T1
ATE414071T1 AT04770635T AT04770635T ATE414071T1 AT E414071 T1 ATE414071 T1 AT E414071T1 AT 04770635 T AT04770635 T AT 04770635T AT 04770635 T AT04770635 T AT 04770635T AT E414071 T1 ATE414071 T1 AT E414071T1
Authority
AT
Austria
Prior art keywords
formula
hydrogen
derivatives
alkali
methyl
Prior art date
Application number
AT04770635T
Other languages
English (en)
Inventor
Milind Moreshwar Gharpure
Swapnil Panditrao Sonawane
Srihari Shivaji Mane
Rajendra Dagesing Mahale
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Application granted granted Critical
Publication of ATE414071T1 publication Critical patent/ATE414071T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
AT04770635T 2004-03-30 2004-03-30 Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten ATE414071T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2004/000075 WO2005095374A1 (en) 2004-03-30 2004-03-30 An improved method for manufacture of 4-hydroxy pyran-2-one derivatives

Publications (1)

Publication Number Publication Date
ATE414071T1 true ATE414071T1 (de) 2008-11-15

Family

ID=34958565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04770635T ATE414071T1 (de) 2004-03-30 2004-03-30 Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten

Country Status (7)

Country Link
US (1) US7777056B2 (de)
EP (1) EP1732912B1 (de)
AT (1) ATE414071T1 (de)
AU (1) AU2004317826A1 (de)
BR (1) BRPI0418644A (de)
DE (1) DE602004017784D1 (de)
WO (1) WO2005095374A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678928B2 (en) 2005-02-04 2010-03-16 Lupin Limited Process for manufacture of simvastatin
JP2009114121A (ja) * 2007-11-06 2009-05-28 Kaneka Corp シンバスタチンの製造方法
CN116253675B (zh) * 2023-05-10 2023-07-25 山东信谊制药有限公司 一种n-取代-2-哌啶酮的合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
DE3713178A1 (de) * 1987-04-17 1988-11-03 Bayer Ag Verfahren zur herstellung eines verbundsystems aus einem gummielastischen material und einer polyurethanschaumstoff-schicht
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
SI9300303A (en) 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
DE877742T1 (de) 1995-12-06 1999-07-22 Antibiotic Co Verfahren zur herstellung von lovastatin
EP0877089A1 (de) 1997-05-07 1998-11-11 Gist-Brocades B.V. Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase
IN186880B (de) 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186879B (de) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
EP1228057A2 (de) * 1999-10-27 2002-08-07 Merck & Co., Inc. Laktonbildungsverfahren
IN191580B (de) 1999-12-17 2003-12-06 Ranbaxy Lab Ltd
IN192861B (de) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
NL1017548C2 (nl) * 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
SK692003A3 (en) 2001-05-18 2003-12-02 Aurobindo Pharma Ltd A process for lactonization to produce highly pure simvastatin
EP1294706A1 (de) 2001-05-18 2003-03-26 Aurobindo Pharma Limited Prozess zur herstellung von simvastatin durch lactonisierung
KR100407758B1 (ko) 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
US6472542B1 (en) * 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100423892B1 (ko) 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법

Also Published As

Publication number Publication date
US7777056B2 (en) 2010-08-17
EP1732912A1 (de) 2006-12-20
EP1732912B1 (de) 2008-11-12
WO2005095374A1 (en) 2005-10-13
US20080269508A1 (en) 2008-10-30
AU2004317826A1 (en) 2005-10-13
BRPI0418644A (pt) 2007-05-29
DE602004017784D1 (de) 2008-12-24

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