ATE414071T1 - Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten - Google Patents
Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivatenInfo
- Publication number
- ATE414071T1 ATE414071T1 AT04770635T AT04770635T ATE414071T1 AT E414071 T1 ATE414071 T1 AT E414071T1 AT 04770635 T AT04770635 T AT 04770635T AT 04770635 T AT04770635 T AT 04770635T AT E414071 T1 ATE414071 T1 AT E414071T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- hydrogen
- derivatives
- alkali
- methyl
- Prior art date
Links
- VNZOLPIHDIJPBZ-UHFFFAOYSA-N 4-hydroxypyran-2-one Chemical class OC=1C=COC(=O)C=1 VNZOLPIHDIJPBZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000012535 impurity Substances 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Chemical group 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydrogen salts Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2004/000075 WO2005095374A1 (en) | 2004-03-30 | 2004-03-30 | An improved method for manufacture of 4-hydroxy pyran-2-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414071T1 true ATE414071T1 (de) | 2008-11-15 |
Family
ID=34958565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04770635T ATE414071T1 (de) | 2004-03-30 | 2004-03-30 | Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7777056B2 (de) |
| EP (1) | EP1732912B1 (de) |
| AT (1) | ATE414071T1 (de) |
| AU (1) | AU2004317826A1 (de) |
| BR (1) | BRPI0418644A (de) |
| DE (1) | DE602004017784D1 (de) |
| WO (1) | WO2005095374A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007009422A (es) * | 2005-02-04 | 2007-10-05 | Lupin Ltd | Proceso para la elaboracion de simvastatina. |
| JP2009114121A (ja) * | 2007-11-06 | 2009-05-28 | Kaneka Corp | シンバスタチンの製造方法 |
| CN116253675B (zh) * | 2023-05-10 | 2023-07-25 | 山东信谊制药有限公司 | 一种n-取代-2-哌啶酮的合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| DE3713178A1 (de) * | 1987-04-17 | 1988-11-03 | Bayer Ag | Verfahren zur herstellung eines verbundsystems aus einem gummielastischen material und einer polyurethanschaumstoff-schicht |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| US4916239A (en) * | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| EA000954B1 (ru) | 1995-12-06 | 2000-08-28 | Балканфарма - Разград Ад | Способ получения ловастатина |
| EP0877089A1 (de) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase |
| IN186880B (de) * | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| IN186879B (de) * | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| CA2388182A1 (en) * | 1999-10-27 | 2001-05-03 | Merck & Co., Inc. | Lactonization process |
| IN191580B (de) * | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd | |
| IN192861B (de) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| NL1017548C2 (nl) * | 2001-03-09 | 2002-09-10 | Synthon Bv | Een lactonisatie proces. |
| SI21235A (sl) | 2001-05-18 | 2003-12-31 | Aurobindo Pharma Limited | Postopek laktonizacije za proizvodnjo simvastatina |
| SK692003A3 (en) | 2001-05-18 | 2003-12-02 | Aurobindo Pharma Ltd | A process for lactonization to produce highly pure simvastatin |
| KR100407758B1 (ko) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
| US6472542B1 (en) * | 2001-11-29 | 2002-10-29 | Fermic S.A. De C.V. | Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin |
| KR100423892B1 (ko) * | 2001-12-03 | 2004-03-22 | 씨제이 주식회사 | 스타틴의 제조에 있어서 새로운 락톤화 방법 |
-
2004
- 2004-03-30 AT AT04770635T patent/ATE414071T1/de not_active IP Right Cessation
- 2004-03-30 WO PCT/IN2004/000075 patent/WO2005095374A1/en not_active Ceased
- 2004-03-30 US US11/547,533 patent/US7777056B2/en not_active Expired - Fee Related
- 2004-03-30 AU AU2004317826A patent/AU2004317826A1/en not_active Abandoned
- 2004-03-30 BR BRPI0418644-3A patent/BRPI0418644A/pt not_active IP Right Cessation
- 2004-03-30 EP EP04770635A patent/EP1732912B1/de not_active Expired - Lifetime
- 2004-03-30 DE DE602004017784T patent/DE602004017784D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004317826A1 (en) | 2005-10-13 |
| DE602004017784D1 (de) | 2008-12-24 |
| EP1732912A1 (de) | 2006-12-20 |
| US7777056B2 (en) | 2010-08-17 |
| US20080269508A1 (en) | 2008-10-30 |
| WO2005095374A1 (en) | 2005-10-13 |
| EP1732912B1 (de) | 2008-11-12 |
| BRPI0418644A (pt) | 2007-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |