ATE321039T1 - Verfahren zur herstellung von losartan und losartan-kaliumsalz - Google Patents

Verfahren zur herstellung von losartan und losartan-kaliumsalz

Info

Publication number
ATE321039T1
ATE321039T1 AT03726536T AT03726536T ATE321039T1 AT E321039 T1 ATE321039 T1 AT E321039T1 AT 03726536 T AT03726536 T AT 03726536T AT 03726536 T AT03726536 T AT 03726536T AT E321039 T1 ATE321039 T1 AT E321039T1
Authority
AT
Austria
Prior art keywords
losartan
alcohol
triarylmethyl
potassium
producing
Prior art date
Application number
AT03726536T
Other languages
English (en)
Inventor
Ben-Zion Dolitzky
Gennady Nisnevich
Igor Rukhman
Julia Kaftanov
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE321039T1 publication Critical patent/ATE321039T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
AT03726536T 2002-04-29 2003-04-29 Verfahren zur herstellung von losartan und losartan-kaliumsalz ATE321039T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37632202P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
ATE321039T1 true ATE321039T1 (de) 2006-04-15

Family

ID=29401331

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726536T ATE321039T1 (de) 2002-04-29 2003-04-29 Verfahren zur herstellung von losartan und losartan-kaliumsalz

Country Status (10)

Country Link
US (1) US7041832B2 (de)
EP (1) EP1474417B1 (de)
AT (1) ATE321039T1 (de)
AU (1) AU2003228767A1 (de)
CA (1) CA2482857A1 (de)
DE (1) DE60304175T2 (de)
ES (1) ES2259412T3 (de)
IL (1) IL164902A0 (de)
PT (1) PT1474417E (de)
WO (1) WO2003093262A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
EP1709034A2 (de) * 2004-01-06 2006-10-11 IPCA Laboratories Limited Verbessertes verfahren zur synthese von losartan-kalium
UA90131C2 (en) 2005-02-03 2010-04-12 Рациофарм Гмбх Method for the production of losartan
WO2006097121A1 (en) * 2005-03-16 2006-09-21 Ulkar Kimya Sanayii Ve Ticaret A.S. Method for producing biphenyl-tetrazole compounds
US20090076281A1 (en) * 2005-05-05 2009-03-19 Medichem, S.A. Process for the preparation of losartan and its salts
EP1741711A1 (de) * 2005-07-04 2007-01-10 KRKA, D.D., Novo Mesto Verfahren zur Herstellung von Losartanderivaten durch Chlorierung und Reduktion der entsprechenden 1H-imidazol-5-carbaldehyde
WO2007062675A1 (en) * 2005-12-01 2007-06-07 Ulkar Kimya Sanayii Ve Ticaret A.S. Method for producing metal salts of losartan
KR20100021454A (ko) * 2007-06-15 2010-02-24 도꾜 다이가꾸 주쇄 골격이 ―Ｓｉ―Ｏ―로 본질적으로 이루어지는 폴리로탁산 및 그의 제조 방법, 및 상기 폴리로탁산을 가교시켜 이루어지는 가교 폴리로탁산 및 그의 제조 방법
CN108047208B (zh) * 2018-01-12 2022-03-22 浙江华海药业股份有限公司 一种降低氯沙坦二聚物杂质的方法
US11327065B1 (en) * 2021-08-27 2022-05-10 Jubilant Generics Limited Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671073A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US5138069A (en) 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0842925A1 (de) 1987-09-04 1998-05-20 Beecham Group Plc Substituierte Thiazolidindionderivate
US5210079A (en) 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5354867A (en) 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5155188A (en) 1988-12-29 1992-10-13 The B. F. Goodrich Company Oxide cocatalysts in ring opening polymerization of polycycloolefins
US5332744A (en) 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US5187069A (en) 1990-08-06 1993-02-16 Henry Ford Health System Active site labelling of plasminogen
GB9017482D0 (en) 1990-08-09 1990-09-26 Ici Plc Manufacturing process
IE914572A1 (en) 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5206374A (en) 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5484955A (en) 1992-07-06 1996-01-16 Takeda Chemical Industries, Ltd. Tri-higher alkyl tin azide and its use
AU685898B2 (en) 1993-12-23 1998-01-29 Du Pont Merck Pharmaceutical Company, The Polymorphs of losartan and the process for the preparation of form II of losartan
CA2186606A1 (en) 1994-03-29 1995-10-05 Edward B. Nelson Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles
GB9406573D0 (en) * 1994-03-31 1994-05-25 Merck Sharp & Dohme Medicaments
US5952509A (en) 1996-06-27 1999-09-14 Takeda Chemical Industries, Ltd. Production of benzaldehyde compounds
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
JP2001226372A (ja) 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
BR0102252B1 (pt) 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso

Also Published As

Publication number Publication date
EP1474417A2 (de) 2004-11-10
US7041832B2 (en) 2006-05-09
PT1474417E (pt) 2006-06-30
ES2259412T3 (es) 2006-10-01
IL164902A0 (en) 2005-12-18
AU2003228767A1 (en) 2003-11-17
CA2482857A1 (en) 2003-11-13
DE60304175D1 (de) 2006-05-11
WO2003093262A3 (en) 2004-03-18
DE60304175T2 (de) 2007-03-15
US20040034077A1 (en) 2004-02-19
EP1474417B1 (de) 2006-03-22
WO2003093262A2 (en) 2003-11-13

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