DE60304175D1 - Verfahren zur herstellung von losartan und losartan-kaliumsalz - Google Patents

Verfahren zur herstellung von losartan und losartan-kaliumsalz

Info

Publication number
DE60304175D1
DE60304175D1 DE60304175T DE60304175T DE60304175D1 DE 60304175 D1 DE60304175 D1 DE 60304175D1 DE 60304175 T DE60304175 T DE 60304175T DE 60304175 T DE60304175 T DE 60304175T DE 60304175 D1 DE60304175 D1 DE 60304175D1
Authority
DE
Germany
Prior art keywords
losartan
alcohol
triarylmethyl
potassium
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60304175T
Other languages
English (en)
Other versions
DE60304175T2 (de
Inventor
Ben-Zion Dolitzky
Gennady Nisnevich
Igor Rukhman
Julia Kaftanov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60304175D1 publication Critical patent/DE60304175D1/de
Publication of DE60304175T2 publication Critical patent/DE60304175T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DE60304175T 2002-04-29 2003-04-29 Verfahren zur herstellung von losartan und losartan-kaliumsalz Expired - Fee Related DE60304175T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37632202P 2002-04-29 2002-04-29
US376322P 2002-04-29
PCT/US2003/013369 WO2003093262A2 (en) 2002-04-29 2003-04-29 Processes for preparing losartan and losartan potassium

Publications (2)

Publication Number Publication Date
DE60304175D1 true DE60304175D1 (de) 2006-05-11
DE60304175T2 DE60304175T2 (de) 2007-03-15

Family

ID=29401331

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60304175T Expired - Fee Related DE60304175T2 (de) 2002-04-29 2003-04-29 Verfahren zur herstellung von losartan und losartan-kaliumsalz

Country Status (10)

Country Link
US (1) US7041832B2 (de)
EP (1) EP1474417B1 (de)
AT (1) ATE321039T1 (de)
AU (1) AU2003228767A1 (de)
CA (1) CA2482857A1 (de)
DE (1) DE60304175T2 (de)
ES (1) ES2259412T3 (de)
IL (1) IL164902A0 (de)
PT (1) PT1474417E (de)
WO (1) WO2003093262A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
EP1709034A2 (de) * 2004-01-06 2006-10-11 IPCA Laboratories Limited Verbessertes verfahren zur synthese von losartan-kalium
US20090111994A1 (en) 2005-02-03 2009-04-30 Ratiopharm Gmbh Method for The Production of Losartan
WO2006097121A1 (en) * 2005-03-16 2006-09-21 Ulkar Kimya Sanayii Ve Ticaret A.S. Method for producing biphenyl-tetrazole compounds
US20090076281A1 (en) * 2005-05-05 2009-03-19 Medichem, S.A. Process for the preparation of losartan and its salts
EP1741711A1 (de) * 2005-07-04 2007-01-10 KRKA, D.D., Novo Mesto Verfahren zur Herstellung von Losartanderivaten durch Chlorierung und Reduktion der entsprechenden 1H-imidazol-5-carbaldehyde
DE602005024726D1 (de) * 2005-12-01 2010-12-23 Ulkar Kimya Sanayii Ve Ticaret Artan
US20100184934A1 (en) * 2007-06-15 2010-07-22 The University Of Tokyo POLYROTAXANE HAVING MAIN CHAIN BACKBONE ESSENTIALLY COMPOSED OF -Si-O- AND METHOD FOR PRODUCING THE SAME, AND CROSSLINKED POLYROTAXANE OBTAINED BY CROSSLINKING THE POLYROTAXANE AND METHOD FOR PRODUCING THE SAME
CN108047208B (zh) * 2018-01-12 2022-03-22 浙江华海药业股份有限公司 一种降低氯沙坦二聚物杂质的方法
US11327065B1 (en) * 2021-08-27 2022-05-10 Jubilant Generics Limited Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671073A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US5138069A (en) 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0842925A1 (de) 1987-09-04 1998-05-20 Beecham Group Plc Substituierte Thiazolidindionderivate
US5210079A (en) 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5354867A (en) 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5155188A (en) 1988-12-29 1992-10-13 The B. F. Goodrich Company Oxide cocatalysts in ring opening polymerization of polycycloolefins
US5332744A (en) 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US5187069A (en) 1990-08-06 1993-02-16 Henry Ford Health System Active site labelling of plasminogen
GB9017482D0 (en) 1990-08-09 1990-09-26 Ici Plc Manufacturing process
IE914572A1 (en) 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5484955A (en) 1992-07-06 1996-01-16 Takeda Chemical Industries, Ltd. Tri-higher alkyl tin azide and its use
EP0736021A4 (de) 1993-12-23 1997-04-02 Merck & Co Inc Polymorphe von losartan und verfahren zur herstellung von form ii losartan
JP3883205B2 (ja) 1994-03-29 2007-02-21 メルク エンド カンパニー インコーポレーテッド アンギオテンシン▲ｉｉ▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療
GB9406573D0 (en) * 1994-03-31 1994-05-25 Merck Sharp & Dohme Medicaments
US5952509A (en) 1996-06-27 1999-09-14 Takeda Chemical Industries, Ltd. Production of benzaldehyde compounds
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
JP2001226372A (ja) 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
BR0102252B1 (pt) 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso

Also Published As

Publication number Publication date
WO2003093262A2 (en) 2003-11-13
CA2482857A1 (en) 2003-11-13
US7041832B2 (en) 2006-05-09
DE60304175T2 (de) 2007-03-15
PT1474417E (pt) 2006-06-30
IL164902A0 (en) 2005-12-18
EP1474417A2 (de) 2004-11-10
US20040034077A1 (en) 2004-02-19
EP1474417B1 (de) 2006-03-22
AU2003228767A1 (en) 2003-11-17
WO2003093262A3 (en) 2004-03-18
ATE321039T1 (de) 2006-04-15
ES2259412T3 (es) 2006-10-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee