ATE370950T1 - Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol - Google Patents

Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol

Info

Publication number
ATE370950T1
ATE370950T1 AT04764776T AT04764776T ATE370950T1 AT E370950 T1 ATE370950 T1 AT E370950T1 AT 04764776 T AT04764776 T AT 04764776T AT 04764776 T AT04764776 T AT 04764776T AT E370950 T1 ATE370950 T1 AT E370950T1
Authority
AT
Austria
Prior art keywords
cyclopentene
purine
cis
chlorine
methanol
Prior art date
Application number
AT04764776T
Other languages
English (en)
Inventor
Ronnie Lawrence
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE370950T1 publication Critical patent/ATE370950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT04764776T 2003-09-04 2004-09-02 Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol ATE370950T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0320738.8A GB0320738D0 (en) 2003-09-04 2003-09-04 Novel process

Publications (1)

Publication Number Publication Date
ATE370950T1 true ATE370950T1 (de) 2007-09-15

Family

ID=29226501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04764776T ATE370950T1 (de) 2003-09-04 2004-09-02 Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol

Country Status (8)

Country Link
US (1) US7557209B2 (de)
EP (1) EP1660498B1 (de)
JP (1) JP2007504196A (de)
AT (1) ATE370950T1 (de)
DE (1) DE602004008486T2 (de)
ES (1) ES2291918T3 (de)
GB (1) GB0320738D0 (de)
WO (1) WO2005023811A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1857458A1 (de) * 2006-05-05 2007-11-21 SOLMAG S.p.A. Verfahren zur Herstellung von Abacavir
EP1939196A1 (de) * 2006-12-21 2008-07-02 Esteve Quimica, S.A. Abacavir-Herstellungsprozess
EP2085397A1 (de) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Kristalline Form von Abacavir
EP2305680A3 (de) * 2009-09-30 2011-05-18 Aurobindo Pharma Limited Neuartige Salze von (1S,4R)-cis-4-[2-amino-6-(cyclopropylamin)-9H-purin-9-yl]-2-cyclopenten-1-methanol
CN103626745B (zh) * 2013-12-04 2016-02-24 青岛黄海制药有限责任公司 一种替卡格雷中间体的制备方法
CN117050024B (zh) * 2023-10-13 2024-01-05 苏州开元民生科技股份有限公司 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728736A (en) * 1984-03-28 1988-03-01 Southern Research Institute Carbocyclic analogs of purine ribofuranosides
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
US4931559A (en) 1988-01-20 1990-06-05 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
JPH05178746A (ja) * 1991-02-12 1993-07-20 Takeda Chem Ind Ltd 抗ウイルス剤
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
JPH07138259A (ja) * 1993-06-30 1995-05-30 Asahi Glass Co Ltd イミダゾール誘導体の製造法
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9709945D0 (en) 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
US6119162A (en) * 1998-09-25 2000-09-12 Actiontec Electronics, Inc. Methods and apparatus for dynamic internet server selection

Also Published As

Publication number Publication date
DE602004008486T2 (de) 2008-05-15
US7557209B2 (en) 2009-07-07
GB0320738D0 (en) 2003-10-08
JP2007504196A (ja) 2007-03-01
WO2005023811A1 (en) 2005-03-17
US20070027316A1 (en) 2007-02-01
EP1660498B1 (de) 2007-08-22
EP1660498A1 (de) 2006-05-31
DE602004008486D1 (de) 2007-10-04
ES2291918T3 (es) 2008-03-01

Similar Documents

Publication Publication Date Title
ATE425136T1 (de) Verfahren zur herstellung substituierter 3-aryl- butyl-aminverbindungen
ATE417036T1 (de) Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen
ATE354583T1 (de) Verfahren zur herstellung c-7 substituierter 5- androstene
ATE370950T1 (de) Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol
DE60015563D1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
ATE415404T1 (de) Lösungsmittelfreies verfahren zur herstellung von diketopyrrolopyrrol-derivaten
ATE489352T1 (de) Verfahren zur herstellung von brenztraubensäure
ATE310735T1 (de) Verfahren zur herstellung von spirocyclischen tetronsäurederivaten
ATE496038T1 (de) Verfahren zur herstellung von quetiapin
DE602004014822D1 (de) Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol
ATE282594T1 (de) Verfahren zur herstellung von (+)-trans-4-p- fluorophenyl-3-hydroxymethyl-1-methylpiperidin
DE602004030091D1 (de) Verfahren zur reduktiven deshalogenierung
ATE417826T1 (de) Verfahren zur herstellung von zwischenprodukten
ATE330612T1 (de) Verfahren zur herstellung von benazeprilhydrochloride
ATE423096T1 (de) Verfahren zur herstellung von 2- azabicycloä3.3.0üoctan-3-carbonsäurederivaten
DE602005013007D1 (de) Verfahren zur herstellung von lactonen
ATE469141T1 (de) Verfahren zur herstellung von substituierten thiophensulfonylisocyanaten
ATE549315T1 (de) Verfahren zur herstellung von kristallinem perindopril
ATE546458T1 (de) Verfahren zur herstellung von 6-alpha, 9-alpha-
ATE375355T1 (de) Verfahren zur herstellung von cefpodoxim-proxetil
ATE360006T1 (de) Verfahren zur racematspaltung von nefopam
ATE425143T1 (de) Verfahren zur herstellung von indolen
DE50203388D1 (de) Verbessertes verfahren zur herstellung von bisphosphiten
ATE490259T1 (de) Verfahren zur herstellung von alkylphosphinaten
ATE297478T1 (de) Verfahren zur herstellung von orthocarbonsäuretrialkylestern

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties