ATE417036T1 - Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen - Google Patents

Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen

Info

Publication number
ATE417036T1
ATE417036T1 AT05757531T AT05757531T ATE417036T1 AT E417036 T1 ATE417036 T1 AT E417036T1 AT 05757531 T AT05757531 T AT 05757531T AT 05757531 T AT05757531 T AT 05757531T AT E417036 T1 ATE417036 T1 AT E417036T1
Authority
AT
Austria
Prior art keywords
hydroxy
hydroxymethyl
producing
improved method
pyrrolidine compounds
Prior art date
Application number
AT05757531T
Other languages
English (en)
Inventor
Dirk Henning Lenz
Jennifer Mary Mason
Keith Clinch
Gary Brian Evans
Peter Charles Tyler
Original Assignee
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Res Ltd filed Critical Ind Res Ltd
Application granted granted Critical
Publication of ATE417036T1 publication Critical patent/ATE417036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT05757531T 2004-06-04 2005-06-03 Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen ATE417036T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ533360A NZ533360A (en) 2004-06-04 2004-06-04 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds

Publications (1)

Publication Number Publication Date
ATE417036T1 true ATE417036T1 (de) 2008-12-15

Family

ID=35462865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05757531T ATE417036T1 (de) 2004-06-04 2005-06-03 Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen

Country Status (19)

Country Link
US (1) US8183019B2 (de)
EP (1) EP1756052B1 (de)
JP (2) JP5219506B2 (de)
KR (1) KR101294732B1 (de)
CN (1) CN101018768B (de)
AT (1) ATE417036T1 (de)
AU (1) AU2005250308B2 (de)
CA (1) CA2568836C (de)
CY (1) CY1108866T1 (de)
DE (1) DE602005011609D1 (de)
DK (1) DK1756052T3 (de)
ES (1) ES2318504T3 (de)
IL (1) IL179749A (de)
MX (1) MXPA06014139A (de)
NZ (1) NZ533360A (de)
PL (1) PL1756052T3 (de)
PT (1) PT1756052E (de)
SI (1) SI1756052T1 (de)
WO (1) WO2005118532A1 (de)

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SI2077268T1 (sl) 1999-04-08 2017-07-31 Victoria Link Limited Postopek za pripravo inhibitorjev nukleozidnega metabolizma
ES2363766T3 (es) 2002-08-21 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
US8541567B2 (en) * 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
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US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
JP2009528996A (ja) * 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
EP2049543B1 (de) * 2006-09-07 2014-11-05 Callaghan Innovation Research Limited Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase
CN101528749B (zh) * 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
KR20090101278A (ko) * 2006-12-22 2009-09-24 인더스트리얼 리서치 리미티드 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체
JP5563483B2 (ja) * 2008-01-25 2014-07-30 ゼノポート，インコーポレイティド アシロキシアルキルカルバメートプロドラッグの合成に使用されるアシロキシアルキルチオカーボネートの鏡像異性的な分解
EP2348854A4 (de) * 2008-09-22 2012-03-14 Einstein Coll Med Verfahren und zusammensetzungen für die behandlung von bakteriellen infektionen durch hemmung des »quorum sensing
AU2010271532B2 (en) 2009-07-17 2016-03-03 Albert Einstein College Of Medicine, Inc. 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
US11186575B2 (en) 2012-08-07 2021-11-30 Alber Einslein College of Medicine Treatment of helicobacter pylori infections
CA3109736A1 (en) 2012-11-12 2014-05-15 Victoria Link Limited Salt and polymorphic forms of (3r,4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrrolidin-3-ol-(mtdia)
EP3104707B1 (de) 2014-02-12 2020-07-15 Albert Einstein College of Medicine, Inc. Behandlung von infektionen mit h. pylori mittels mtan-inhibitoren
CN104529814A (zh) * 2014-12-15 2015-04-22 上海同昌生物医药科技有限公司 一种合成n-苄基羟胺盐酸盐的方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法
CN120136758A (zh) * 2025-03-14 2025-06-13 宏济堂制药(商河)有限公司 一种氯马斯汀中间体的合成方法

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JP3504026B2 (ja) 1995-06-16 2004-03-08 株式会社トクヤマ ピロリジン誘導体の製造方法
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US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
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US6239163B1 (en) * 1999-03-15 2001-05-29 Novo Nordisk A/S Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine
SI2077268T1 (sl) * 1999-04-08 2017-07-31 Victoria Link Limited Postopek za pripravo inhibitorjev nukleozidnega metabolizma
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ATE443064T1 (de) 2002-03-18 2009-10-15 Kyorin Seiyaku Kk 10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterien
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ES2363766T3 (es) * 2002-08-21 2011-08-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibidores de nucleosidasas y fosforilasas de nucleosidos.
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
WO2005003307A2 (en) 2003-06-17 2005-01-13 The Regents Of The University Of California Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes
US7777025B2 (en) * 2003-09-09 2010-08-17 Albert Einstein College Of Medicine Of Yeshiva University Transition state analog inhibitors of ricin A-chain
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
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NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
US8541567B2 (en) 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
JP2009528996A (ja) 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
EP2007718A2 (de) * 2006-03-29 2008-12-31 Medichem, S.A. Verfahren zur herstellung von ezetimibe und zu dessen herstellung nützliche zwischenverbindungen
EP2049543B1 (de) * 2006-09-07 2014-11-05 Callaghan Innovation Research Limited Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
US20100062995A1 (en) * 2006-09-26 2010-03-11 Schramm Vern L Transition state structure of human 5'methylthioadenosine phosphorylase
KR20090101278A (ko) 2006-12-22 2009-09-24 인더스트리얼 리서치 리미티드 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
EP2348854A4 (de) 2008-09-22 2012-03-14 Einstein Coll Med Verfahren und zusammensetzungen für die behandlung von bakteriellen infektionen durch hemmung des »quorum sensing
AU2010271532B2 (en) 2009-07-17 2016-03-03 Albert Einstein College Of Medicine, Inc. 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

Also Published As

Publication number Publication date
EP1756052A4 (de) 2007-08-22
CN101018768B (zh) 2012-11-21
PL1756052T3 (pl) 2009-05-29
EP1756052A1 (de) 2007-02-28
KR101294732B1 (ko) 2013-08-12
US20080280334A1 (en) 2008-11-13
IL179749A0 (en) 2007-05-15
AU2005250308B2 (en) 2012-04-26
KR20070050037A (ko) 2007-05-14
CY1108866T1 (el) 2014-07-02
IL179749A (en) 2011-07-31
PT1756052E (pt) 2009-02-11
SI1756052T1 (sl) 2009-04-30
JP2008501682A (ja) 2008-01-24
DE602005011609D1 (de) 2009-01-22
NZ533360A (en) 2007-02-23
US8183019B2 (en) 2012-05-22
CN101018768A (zh) 2007-08-15
WO2005118532A1 (en) 2005-12-15
JP5219506B2 (ja) 2013-06-26
CA2568836C (en) 2013-04-16
CA2568836A1 (en) 2005-12-15
AU2005250308A1 (en) 2005-12-15
HK1106518A1 (en) 2008-03-14
DK1756052T3 (da) 2009-03-09
EP1756052B1 (de) 2008-12-10
ES2318504T3 (es) 2009-05-01
MXPA06014139A (es) 2007-05-09
JP2012211136A (ja) 2012-11-01

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