ATE417036T1 - Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen - Google Patents
Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungenInfo
- Publication number
- ATE417036T1 ATE417036T1 AT05757531T AT05757531T ATE417036T1 AT E417036 T1 ATE417036 T1 AT E417036T1 AT 05757531 T AT05757531 T AT 05757531T AT 05757531 T AT05757531 T AT 05757531T AT E417036 T1 ATE417036 T1 AT E417036T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- hydroxymethyl
- producing
- improved method
- pyrrolidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ533360A NZ533360A (en) | 2004-06-04 | 2004-06-04 | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE417036T1 true ATE417036T1 (de) | 2008-12-15 |
Family
ID=35462865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05757531T ATE417036T1 (de) | 2004-06-04 | 2005-06-03 | Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen |
Country Status (20)
Country | Link |
---|---|
US (1) | US8183019B2 (de) |
EP (1) | EP1756052B1 (de) |
JP (2) | JP5219506B2 (de) |
KR (1) | KR101294732B1 (de) |
CN (1) | CN101018768B (de) |
AT (1) | ATE417036T1 (de) |
AU (1) | AU2005250308B2 (de) |
CA (1) | CA2568836C (de) |
CY (1) | CY1108866T1 (de) |
DE (1) | DE602005011609D1 (de) |
DK (1) | DK1756052T3 (de) |
ES (1) | ES2318504T3 (de) |
HK (1) | HK1106518A1 (de) |
IL (1) | IL179749A (de) |
MX (1) | MXPA06014139A (de) |
NZ (1) | NZ533360A (de) |
PL (1) | PL1756052T3 (de) |
PT (1) | PT1756052E (de) |
SI (1) | SI1756052T1 (de) |
WO (1) | WO2005118532A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
CA2634299C (en) | 1999-04-08 | 2011-05-31 | Industrial Research Limited | Process for preparing inhibitors of nucleoside metabolism |
EP1539783B1 (de) | 2002-08-21 | 2011-04-13 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitoren von nukleosidphosphorylasen und nukleosidasen |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
CN1329374C (zh) * | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
AU2006275725A1 (en) * | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
NZ544187A (en) * | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
WO2007097643A1 (en) * | 2006-02-22 | 2007-08-30 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
WO2007097647A1 (en) | 2006-02-24 | 2007-08-30 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer |
US20110092521A1 (en) * | 2006-02-24 | 2011-04-21 | Richard Hubert Furneaux | Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases |
CN101094080B (zh) * | 2006-06-22 | 2012-06-20 | 华为技术有限公司 | 一种即按即通系统中的计费方法 |
PL2057165T3 (pl) * | 2006-09-07 | 2011-08-31 | Victoria Link Ltd | Acykliczne inhibitory aminowe fosforylaz i hydrolaz nukleozydowych |
WO2008030118A1 (en) | 2006-09-07 | 2008-03-13 | Industrial Research Limited | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
CN101600711A (zh) * | 2006-12-22 | 2009-12-09 | 工业研究有限公司 | 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物 |
US8062870B2 (en) * | 2008-01-25 | 2011-11-22 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
WO2010033236A2 (en) * | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
EP2454263B1 (de) | 2009-07-17 | 2018-06-13 | Albert Einstein College of Medicine, Inc. | 3-hydroxypyrrolidinhemmer von 5'-methylthioadenosin-phosphorylase und -nucleosidase |
WO2012074912A1 (en) | 2010-11-29 | 2012-06-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
WO2014025842A1 (en) | 2012-08-07 | 2014-02-13 | Albert Einstein College Of Medicine Of Yeshiva University | Treatment of helicobacter pylori infections |
US9994574B2 (en) | 2012-11-12 | 2018-06-12 | Victoria Link Limited | Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA) |
US10118928B2 (en) | 2014-02-12 | 2018-11-06 | Albert Einstein College Of Medicine, Inc. | Treatment of H. pylori infections using MTAN inhibitors |
CN104529814A (zh) * | 2014-12-15 | 2015-04-22 | 上海同昌生物医药科技有限公司 | 一种合成n-苄基羟胺盐酸盐的方法 |
CN111793017B (zh) * | 2019-04-04 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种内酰胺化合物的制备方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3504026B2 (ja) | 1995-06-16 | 2004-03-08 | 株式会社トクヤマ | ピロリジン誘導体の製造方法 |
US6379911B2 (en) | 1996-02-23 | 2002-04-30 | Albert Einstein College Of Medicine Of Yeshiva University | Enzyme detection/assay method and substrates |
US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
US6239163B1 (en) | 1999-03-15 | 2001-05-29 | Novo Nordisk A/S | Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
DE60022172D1 (de) | 1999-03-15 | 2005-09-29 | Novo Nordisk As | Salz des (2r,3r,4r)3,4-dihydroxy-2-hydroxymethylpyrrolidins |
CA2634299C (en) | 1999-04-08 | 2011-05-31 | Industrial Research Limited | Process for preparing inhibitors of nucleoside metabolism |
US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
JP2004507534A (ja) | 2000-08-29 | 2004-03-11 | インダストリアル リサーチ リミテッド | ヌクレオシド代謝阻害剤 |
US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
EP1486500B1 (de) * | 2002-03-18 | 2009-09-16 | Kyorin Pharmaceutical Co., Ltd. | 10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterien |
US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
EP1539783B1 (de) | 2002-08-21 | 2011-04-13 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitoren von nukleosidphosphorylasen und nukleosidasen |
NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
US20060216775A1 (en) | 2003-06-17 | 2006-09-28 | The Regents Of The University Of Califoenia | Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes |
CA2538169A1 (en) * | 2003-09-09 | 2005-03-17 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state analog inhibitors of ricin a-chain |
CN1329374C (zh) | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
EP1771452A4 (de) | 2004-07-27 | 2009-07-15 | Biocryst Pharm Inc | 5'-methylthioadenosin-phosphorylase- und 5'methylthioadenosin-/s-adenosylhomocystein-nucleosidase-hemmer |
NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
AU2006275725A1 (en) | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
US20110092521A1 (en) | 2006-02-24 | 2011-04-21 | Richard Hubert Furneaux | Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases |
WO2007097647A1 (en) | 2006-02-24 | 2007-08-30 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer |
WO2007144780A2 (en) * | 2006-03-29 | 2007-12-21 | Medichem S.A. | Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof |
PL2057165T3 (pl) | 2006-09-07 | 2011-08-31 | Victoria Link Ltd | Acykliczne inhibitory aminowe fosforylaz i hydrolaz nukleozydowych |
WO2008030118A1 (en) | 2006-09-07 | 2008-03-13 | Industrial Research Limited | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
AU2007300624A1 (en) | 2006-09-26 | 2008-04-03 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of human 5'-methylthioadenosine phosphorylase |
CN101600711A (zh) | 2006-12-22 | 2009-12-09 | 工业研究有限公司 | 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物 |
WO2009082247A1 (en) | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
WO2010033236A2 (en) | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
EP2454263B1 (de) | 2009-07-17 | 2018-06-13 | Albert Einstein College of Medicine, Inc. | 3-hydroxypyrrolidinhemmer von 5'-methylthioadenosin-phosphorylase und -nucleosidase |
-
2004
- 2004-06-04 NZ NZ533360A patent/NZ533360A/en not_active IP Right Cessation
-
2005
- 2005-06-03 PL PL05757531T patent/PL1756052T3/pl unknown
- 2005-06-03 PT PT05757531T patent/PT1756052E/pt unknown
- 2005-06-03 DK DK05757531T patent/DK1756052T3/da active
- 2005-06-03 AU AU2005250308A patent/AU2005250308B2/en not_active Ceased
- 2005-06-03 KR KR1020077000157A patent/KR101294732B1/ko not_active IP Right Cessation
- 2005-06-03 AT AT05757531T patent/ATE417036T1/de active
- 2005-06-03 MX MXPA06014139A patent/MXPA06014139A/es active IP Right Grant
- 2005-06-03 JP JP2007514966A patent/JP5219506B2/ja not_active Expired - Fee Related
- 2005-06-03 ES ES05757531T patent/ES2318504T3/es active Active
- 2005-06-03 EP EP05757531A patent/EP1756052B1/de not_active Not-in-force
- 2005-06-03 US US11/628,427 patent/US8183019B2/en active Active
- 2005-06-03 SI SI200530574T patent/SI1756052T1/sl unknown
- 2005-06-03 CA CA2568836A patent/CA2568836C/en not_active Expired - Fee Related
- 2005-06-03 WO PCT/NZ2005/000114 patent/WO2005118532A1/en active Application Filing
- 2005-06-03 DE DE602005011609T patent/DE602005011609D1/de active Active
- 2005-06-03 CN CN2005800234431A patent/CN101018768B/zh not_active Expired - Fee Related
-
2006
- 2006-11-30 IL IL179749A patent/IL179749A/en not_active IP Right Cessation
-
2007
- 2007-11-02 HK HK07111895.6A patent/HK1106518A1/xx not_active IP Right Cessation
-
2009
- 2009-03-10 CY CY20091100263T patent/CY1108866T1/el unknown
-
2012
- 2012-05-10 JP JP2012108801A patent/JP2012211136A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US8183019B2 (en) | 2012-05-22 |
EP1756052A1 (de) | 2007-02-28 |
JP2008501682A (ja) | 2008-01-24 |
CY1108866T1 (el) | 2014-07-02 |
CA2568836C (en) | 2013-04-16 |
DE602005011609D1 (de) | 2009-01-22 |
CN101018768A (zh) | 2007-08-15 |
JP2012211136A (ja) | 2012-11-01 |
CN101018768B (zh) | 2012-11-21 |
US20080280334A1 (en) | 2008-11-13 |
HK1106518A1 (en) | 2008-03-14 |
EP1756052B1 (de) | 2008-12-10 |
DK1756052T3 (da) | 2009-03-09 |
AU2005250308B2 (en) | 2012-04-26 |
NZ533360A (en) | 2007-02-23 |
EP1756052A4 (de) | 2007-08-22 |
IL179749A (en) | 2011-07-31 |
MXPA06014139A (es) | 2007-05-09 |
IL179749A0 (en) | 2007-05-15 |
AU2005250308A1 (en) | 2005-12-15 |
CA2568836A1 (en) | 2005-12-15 |
KR101294732B1 (ko) | 2013-08-12 |
WO2005118532A1 (en) | 2005-12-15 |
ES2318504T3 (es) | 2009-05-01 |
JP5219506B2 (ja) | 2013-06-26 |
PL1756052T3 (pl) | 2009-05-29 |
PT1756052E (pt) | 2009-02-11 |
SI1756052T1 (sl) | 2009-04-30 |
KR20070050037A (ko) | 2007-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE417036T1 (de) | Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen | |
DE602006021411D1 (de) | Verfahren zur herstellung von optional 2-substituierten 1,6-dihydro-6-oxo-4-pyrimidincarboxylsäuren | |
ATE453622T1 (de) | Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren | |
ATE424392T1 (de) | Verfahren zur herstellung von enantiomerenreinen aminoalkoholen | |
ATE440815T1 (de) | Verfahren zur herstellung von dialkylcarbonaten | |
ATE489352T1 (de) | Verfahren zur herstellung von brenztraubensäure | |
ATE466015T1 (de) | Verfahren zur herstellung von phenserin und dessen analogon | |
ATE437869T1 (de) | Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere | |
ATE407130T1 (de) | Verfahren zur herstellung von 2- azetidinonderivaten | |
WO2006034812A3 (de) | Verfahren zur herstellung von optisch aktiven 2-methylalkan-1-ols aus dem entsprechenden 2-methylalk-2-en-1-al, umfassend eine carbonylselektive reduktion, eine enantioselektive hydrierung und eine lipase-katalysierte, stereoselektive acylierung zwecks anreicherung des gewünschten enatiomers | |
ATE457356T1 (de) | Verfahren zur herstellung von vorwiegend ein enantiomer enthaltendes 1,1,1-trifluorisopropanol | |
ATE281434T1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
ATE459723T1 (de) | Verfahren zur herstellung von (4s)-3,4-dihydroxy- 2,6,6-trimethyl-cyclohex-2-enon und derivaten davon unter verwendung der azoarcus phenylethanol dehydrogenase | |
ATE427306T1 (de) | Verfahren zur herstellung von escitalopram | |
ATE368661T1 (de) | Verfahren zur herstellung von 5-(4-fluorphenyl)-1- 2-((2r,4r)-4-hydroxy-6-oxo etrahydropyran-2- yl)ethylö-2-isopropyl-4-phenyl-1h-pyrrol-3- carbonsäurephenylamid | |
ATE370950T1 (de) | Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol | |
DE602005013007D1 (de) | Verfahren zur herstellung von lactonen | |
GB0417063D0 (en) | Process for the preparation of optically-active compounds | |
DE602004006021D1 (de) | Verfahren zur racematspaltung von nefopam | |
DE602004030091D1 (de) | Verfahren zur reduktiven deshalogenierung | |
ATE439333T1 (de) | Verfahren zur herstellung optisch aktiver propoxyanilinderivate | |
ATE375355T1 (de) | Verfahren zur herstellung von cefpodoxim-proxetil | |
DE502005003019D1 (de) | Verfahren zur herstellung der enantiomeren formen von 2,3-diaminopropionsäurederivaten | |
ATE525357T1 (de) | Verfahren zur herstellung von cyclohexandiessigsäuremonoamid | |
ATE485387T1 (de) | Verfahren zur herstellung enantioreiner beta- aminosäurederivate sowie enantioreine beta- aminosäurederivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1756052 Country of ref document: EP |