DE602005011609D1 - Verbessertes verfahren zur herstellung von 3-hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen - Google Patents

Verbessertes verfahren zur herstellung von 3-hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen

Info

Publication number
DE602005011609D1
DE602005011609D1 DE602005011609T DE602005011609T DE602005011609D1 DE 602005011609 D1 DE602005011609 D1 DE 602005011609D1 DE 602005011609 T DE602005011609 T DE 602005011609T DE 602005011609 T DE602005011609 T DE 602005011609T DE 602005011609 D1 DE602005011609 D1 DE 602005011609D1
Authority
DE
Germany
Prior art keywords
hydroxy
hydroxymethyl
production
improved method
pyrrolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005011609T
Other languages
English (en)
Inventor
Dirk Henning Lenz
Jennifer Mary Mason
Keith Clinch
Gary Brian Evans
Peter Charles Tyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IND RES Ltd
Industrial Research Ltd
Original Assignee
IND RES Ltd
Industrial Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND RES Ltd, Industrial Research Ltd filed Critical IND RES Ltd
Publication of DE602005011609D1 publication Critical patent/DE602005011609D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
DE602005011609T 2004-06-04 2005-06-03 Verbessertes verfahren zur herstellung von 3-hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen Active DE602005011609D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ533360A NZ533360A (en) 2004-06-04 2004-06-04 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
PCT/NZ2005/000114 WO2005118532A1 (en) 2004-06-04 2005-06-03 Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds

Publications (1)

Publication Number Publication Date
DE602005011609D1 true DE602005011609D1 (de) 2009-01-22

Family

ID=35462865

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005011609T Active DE602005011609D1 (de) 2004-06-04 2005-06-03 Verbessertes verfahren zur herstellung von 3-hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen

Country Status (20)

Country Link
US (1) US8183019B2 (de)
EP (1) EP1756052B1 (de)
JP (2) JP5219506B2 (de)
KR (1) KR101294732B1 (de)
CN (1) CN101018768B (de)
AT (1) ATE417036T1 (de)
AU (1) AU2005250308B2 (de)
CA (1) CA2568836C (de)
CY (1) CY1108866T1 (de)
DE (1) DE602005011609D1 (de)
DK (1) DK1756052T3 (de)
ES (1) ES2318504T3 (de)
HK (1) HK1106518A1 (de)
IL (1) IL179749A (de)
MX (1) MXPA06014139A (de)
NZ (1) NZ533360A (de)
PL (1) PL1756052T3 (de)
PT (1) PT1756052E (de)
SI (1) SI1756052T1 (de)
WO (1) WO2005118532A1 (de)

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US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
CN1196704C (zh) 1999-04-08 2005-04-13 工业研究有限公司 制备核苷代谢抑制剂的方法及中间体化合物
DE60336734D1 (de) 2002-08-21 2011-05-26 Ind Res Ltd Sidasen
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
US8541567B2 (en) * 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8394950B2 (en) 2006-02-22 2013-03-12 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
EP1991231A4 (de) * 2006-02-24 2010-01-06 Ind Res Ltd Verfahren zur behandlung von erkrankungen mit hemmern von nucleosid-phosphorylasen und nucleosidasen
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
EP2049543B1 (de) * 2006-09-07 2014-11-05 Callaghan Innovation Research Limited Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
CN101600711A (zh) 2006-12-22 2009-12-09 工业研究有限公司 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
JP5563483B2 (ja) * 2008-01-25 2014-07-30 ゼノポート，インコーポレイティド アシロキシアルキルカルバメートプロドラッグの合成に使用されるアシロキシアルキルチオカーボネートの鏡像異性的な分解
WO2010033236A2 (en) * 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
WO2012074912A1 (en) 2010-11-29 2012-06-07 Albert Einstein College Of Medicine Of Yeshiva University Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
US9994574B2 (en) 2012-11-12 2018-06-12 Victoria Link Limited Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA)
SG10201806381VA (en) 2014-02-12 2018-08-30 Albert Einstein College Medicine Inc Treatment of h. pylori infections using mtan inhibitors
CN104529814A (zh) * 2014-12-15 2015-04-22 上海同昌生物医药科技有限公司 一种合成n-苄基羟胺盐酸盐的方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3504026B2 (ja) 1995-06-16 2004-03-08 株式会社トクヤマ ピロリジン誘導体の製造方法
US6379911B2 (en) * 1996-02-23 2002-04-30 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
EP1163218B1 (de) 1999-03-15 2005-08-24 Novo Nordisk A/S Salz des (2r,3r,4r)3,4-dihydroxy-2-hydroxymethylpyrrolidins
US6239163B1 (en) * 1999-03-15 2001-05-29 Novo Nordisk A/S Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine
CN1196704C (zh) * 1999-04-08 2005-04-13 工业研究有限公司 制备核苷代谢抑制剂的方法及中间体化合物
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
WO2002018371A1 (en) * 2000-08-29 2002-03-07 Industrial Research Limited Nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7153851B2 (en) 2002-03-18 2006-12-26 Kyorin Pharmaceutical Co., Ltd. 10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
DE60336734D1 (de) * 2002-08-21 2011-05-26 Ind Res Ltd Sidasen
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US20060216775A1 (en) 2003-06-17 2006-09-28 The Regents Of The University Of Califoenia Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes
CA2538169A1 (en) * 2003-09-09 2005-03-17 Albert Einstein College Of Medicine Of Yeshiva University Transition state analog inhibitors of ricin a-chain
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
WO2006014913A2 (en) 2004-07-27 2006-02-09 Biocryst Pharmaceuticals, Inc. Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
US8541567B2 (en) 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
EP1991231A4 (de) 2006-02-24 2010-01-06 Ind Res Ltd Verfahren zur behandlung von erkrankungen mit hemmern von nucleosid-phosphorylasen und nucleosidasen
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
CA2647902A1 (en) * 2006-03-29 2007-12-21 Medichem S.A. Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
EP2049543B1 (de) * 2006-09-07 2014-11-05 Callaghan Innovation Research Limited Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase
AU2007300624A1 (en) * 2006-09-26 2008-04-03 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of human 5'-methylthioadenosine phosphorylase
CN101600711A (zh) 2006-12-22 2009-12-09 工业研究有限公司 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
WO2010033236A2 (en) 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase

Also Published As

Publication number Publication date
IL179749A (en) 2011-07-31
EP1756052B1 (de) 2008-12-10
CY1108866T1 (el) 2014-07-02
AU2005250308A1 (en) 2005-12-15
CN101018768A (zh) 2007-08-15
KR101294732B1 (ko) 2013-08-12
ATE417036T1 (de) 2008-12-15
JP2008501682A (ja) 2008-01-24
AU2005250308B2 (en) 2012-04-26
CA2568836C (en) 2013-04-16
CA2568836A1 (en) 2005-12-15
US20080280334A1 (en) 2008-11-13
PL1756052T3 (pl) 2009-05-29
US8183019B2 (en) 2012-05-22
PT1756052E (pt) 2009-02-11
SI1756052T1 (sl) 2009-04-30
KR20070050037A (ko) 2007-05-14
CN101018768B (zh) 2012-11-21
HK1106518A1 (en) 2008-03-14
NZ533360A (en) 2007-02-23
WO2005118532A1 (en) 2005-12-15
DK1756052T3 (da) 2009-03-09
EP1756052A4 (de) 2007-08-22
JP2012211136A (ja) 2012-11-01
JP5219506B2 (ja) 2013-06-26
EP1756052A1 (de) 2007-02-28
IL179749A0 (en) 2007-05-15
ES2318504T3 (es) 2009-05-01
MXPA06014139A (es) 2007-05-09

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