ATE466015T1 - Verfahren zur herstellung von phenserin und dessen analogon - Google Patents
Verfahren zur herstellung von phenserin und dessen analogonInfo
- Publication number
- ATE466015T1 ATE466015T1 AT02790077T AT02790077T ATE466015T1 AT E466015 T1 ATE466015 T1 AT E466015T1 AT 02790077 T AT02790077 T AT 02790077T AT 02790077 T AT02790077 T AT 02790077T AT E466015 T1 ATE466015 T1 AT E466015T1
- Authority
- AT
- Austria
- Prior art keywords
- phenserine
- analogue
- producing
- compounds
- isocyanate
- Prior art date
Links
- PBHFNBQPZCRWQP-QUCCMNQESA-N [(3ar,8bs)-3,4,8b-trimethyl-2,3a-dihydro-1h-pyrrolo[2,3-b]indol-7-yl] n-phenylcarbamate Chemical compound CN([C@@H]1[C@@](C2=C3)(C)CCN1C)C2=CC=C3OC(=O)NC1=CC=CC=C1 PBHFNBQPZCRWQP-QUCCMNQESA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- -1 eseroline compound Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical class C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/042,586 US6495700B1 (en) | 2002-01-09 | 2002-01-09 | Process for producing phenserine and its analog |
| PCT/US2002/039537 WO2003059909A1 (en) | 2002-01-09 | 2002-12-11 | A process for producing phenserine and its analog |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466015T1 true ATE466015T1 (de) | 2010-05-15 |
Family
ID=21922704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02790077T ATE466015T1 (de) | 2002-01-09 | 2002-12-11 | Verfahren zur herstellung von phenserin und dessen analogon |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6495700B1 (de) |
| EP (1) | EP1463729B1 (de) |
| JP (1) | JP2005514459A (de) |
| KR (2) | KR20060097772A (de) |
| CN (1) | CN1301995C (de) |
| AT (1) | ATE466015T1 (de) |
| AU (1) | AU2002353102B2 (de) |
| BR (1) | BRPI0215492A2 (de) |
| CA (1) | CA2470560C (de) |
| DE (1) | DE60236207D1 (de) |
| HR (1) | HRP20040606A2 (de) |
| HU (1) | HUP0500747A3 (de) |
| IL (1) | IL162827A0 (de) |
| PL (1) | PL374240A1 (de) |
| WO (1) | WO2003059909A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004285893B2 (en) | 2003-10-21 | 2011-12-15 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
| WO2006138385A2 (en) * | 2005-06-14 | 2006-12-28 | Cancog Technologies Inc.24 | Use of phenserine and analogs to treat behavioral problems and improve trainability |
| EP2258357A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| AU2006282896A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| US7998971B2 (en) * | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
| CN102905532A (zh) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| US20120225922A1 (en) | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
| US20130096316A1 (en) * | 2011-10-14 | 2013-04-18 | Qr Pharma, Inc. | Novel Method for Preparation of Bisnorcymerine and Salts Thereof |
| EP3610890A1 (de) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Verfahren und zusammensetzungen zur behandlung von schizophrenie |
| EP2968237A4 (de) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| US10159648B2 (en) | 2015-05-22 | 2018-12-25 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| CA2994974C (en) | 2015-08-14 | 2024-04-09 | Qr Pharma | Methods of treatment or prevention of acute brain or nerve injuries |
| WO2018217892A1 (en) | 2017-05-24 | 2018-11-29 | Qr Pharma, Inc. | Prevention or treatment of disease states due to metal dis-homeostasis via administration of posiphen to healthy or sick humans |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1109003B (it) * | 1977-09-20 | 1985-12-16 | Univ Firenze | Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo |
| IT1199076B (it) | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
| US5306825A (en) | 1984-03-01 | 1994-04-26 | Consiglio Nazionale Delle Ricerche | Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process |
| US4791107A (en) | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
| US5187165A (en) | 1987-05-15 | 1993-02-16 | Hoechst-Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles |
| US4900748A (en) | 1988-03-04 | 1990-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates related to (-)-physostigmine as cholinergic agents |
| US5260452A (en) | 1989-11-03 | 1993-11-09 | Hoechst-Roussel Pharmaceuticals Inc. | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof |
| US5077289A (en) | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
| US5177101A (en) | 1989-11-30 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
| US5705657A (en) | 1991-02-14 | 1998-01-06 | Labochim Laboratorio Chimico Internazionale S.P.A. | Isocyanate process for the preparation of 1,3A,8-trimethyl-1,2,3,3A, 8, 8A-hexahydro-pyrrole 2,3-B! indol-5 (3AS, 8AR) -hepthylcarbamate |
| EP0499959A1 (de) | 1991-02-18 | 1992-08-26 | Bromine Compounds Ltd. | Verfahren zur Herstellung von substituierten Haleimiden |
| JP3708957B2 (ja) | 1991-09-26 | 2005-10-19 | アメリカ合衆国 | （−）−エゼロリン、（−）−ｎ１−ノルエゼロリンおよび（−）−ｎ１−ベンジルノルエゼロリンの置換フェンゼリンおよびフェニルカルバミン酸塩：特異的アセチルコリンエステラーゼ阻害薬としての使用 |
| US5206260A (en) | 1991-11-07 | 1993-04-27 | Merck & Co., Inc. | Hexahydropyrrolo[2,3-b]indole derivatives |
| US5302721A (en) | 1992-07-21 | 1994-04-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of preparation of physostigmine carbamate derivatives from eseretholes |
| FI990752A0 (fi) * | 1992-07-21 | 1999-04-06 | Hoechst Marion Roussel Inc | Menetelmä fysostigmiinikarbamaattijohdannaisten valmistamiseksi fysostigmiinistä |
| US5409948A (en) | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| US5665880A (en) | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
| US5677457A (en) | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
-
2002
- 2002-01-09 US US10/042,586 patent/US6495700B1/en not_active Expired - Lifetime
- 2002-12-11 KR KR1020067017072A patent/KR20060097772A/ko not_active Ceased
- 2002-12-11 AT AT02790077T patent/ATE466015T1/de active
- 2002-12-11 KR KR1020047010683A patent/KR100712003B1/ko not_active Expired - Fee Related
- 2002-12-11 WO PCT/US2002/039537 patent/WO2003059909A1/en not_active Ceased
- 2002-12-11 CN CNB028269985A patent/CN1301995C/zh not_active Expired - Fee Related
- 2002-12-11 HR HRP20040606 patent/HRP20040606A2/hr not_active Application Discontinuation
- 2002-12-11 JP JP2003560012A patent/JP2005514459A/ja active Pending
- 2002-12-11 BR BRPI0215492A patent/BRPI0215492A2/pt not_active IP Right Cessation
- 2002-12-11 IL IL16282702A patent/IL162827A0/xx unknown
- 2002-12-11 PL PL02374240A patent/PL374240A1/xx unknown
- 2002-12-11 HU HU0500747A patent/HUP0500747A3/hu unknown
- 2002-12-11 EP EP02790077A patent/EP1463729B1/de not_active Expired - Lifetime
- 2002-12-11 AU AU2002353102A patent/AU2002353102B2/en not_active Ceased
- 2002-12-11 DE DE60236207T patent/DE60236207D1/de not_active Expired - Lifetime
- 2002-12-11 CA CA002470560A patent/CA2470560C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0500747A2 (hu) | 2005-11-28 |
| HUP0500747A3 (en) | 2009-05-28 |
| EP1463729A1 (de) | 2004-10-06 |
| DE60236207D1 (de) | 2010-06-10 |
| PL374240A1 (en) | 2005-10-03 |
| HK1075659A1 (en) | 2005-12-23 |
| IL162827A0 (en) | 2005-11-20 |
| EP1463729B1 (de) | 2010-04-28 |
| JP2005514459A (ja) | 2005-05-19 |
| CA2470560C (en) | 2007-05-15 |
| BRPI0215492A2 (pt) | 2016-07-05 |
| CN1612880A (zh) | 2005-05-04 |
| KR100712003B1 (ko) | 2007-05-02 |
| HRP20040606A2 (en) | 2004-12-31 |
| US6495700B1 (en) | 2002-12-17 |
| WO2003059909A1 (en) | 2003-07-24 |
| KR20060097772A (ko) | 2006-09-15 |
| AU2002353102B2 (en) | 2007-05-24 |
| KR20040072711A (ko) | 2004-08-18 |
| AU2002353102A1 (en) | 2003-07-30 |
| CN1301995C (zh) | 2007-02-28 |
| EP1463729A4 (de) | 2005-06-29 |
| CA2470560A1 (en) | 2003-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE466015T1 (de) | Verfahren zur herstellung von phenserin und dessen analogon | |
| ATE534629T1 (de) | Verfahren und verbindungen zur herstellung von cc-1065-analoga | |
| ATE501126T1 (de) | Verfahren zur herstellung von rosuvastatin | |
| ATE489365T1 (de) | Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon | |
| DE60328492D1 (de) | Verfahren zur erzeugung von nanoteilchen | |
| ATE381727T1 (de) | Verfahren zur multiphotonen-photosensibilisierung | |
| ATE425136T1 (de) | Verfahren zur herstellung substituierter 3-aryl- butyl-aminverbindungen | |
| DE60317651D1 (de) | Verfahren zur herstellung von hochmolekularen verbindungen für photoresists | |
| ATE417036T1 (de) | Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen | |
| ATE360653T1 (de) | Verfahren zur herstellung von polyisobutenen | |
| ATE456569T1 (de) | Verfahren zur herstellung von 6-alkyliden- penemderivaten | |
| ATE431339T1 (de) | Verfahren zur herstellung von n-amino- substituierten heterocyclischen verbindungen | |
| ATE470657T1 (de) | Verfahren zur herstellung von isocyanaten | |
| ATE322495T1 (de) | Verfahren zur herstellung von kristallinem n- formimidoylthienamycin-monohydrat (imipenem- monohydrat) | |
| DE60015563D1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
| ATE515496T1 (de) | Verfahren zur herstellung von enantiomerenangereicherter indolin-2-carbonsäure | |
| ATE528280T1 (de) | Verfahren zur herstellung von triethanolamin | |
| ATE489352T1 (de) | Verfahren zur herstellung von brenztraubensäure | |
| ATE370950T1 (de) | Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol | |
| ATE282594T1 (de) | Verfahren zur herstellung von (+)-trans-4-p- fluorophenyl-3-hydroxymethyl-1-methylpiperidin | |
| ATE549315T1 (de) | Verfahren zur herstellung von kristallinem perindopril | |
| ATE375355T1 (de) | Verfahren zur herstellung von cefpodoxim-proxetil | |
| ATE469141T1 (de) | Verfahren zur herstellung von substituierten thiophensulfonylisocyanaten | |
| ATE330612T1 (de) | Verfahren zur herstellung von benazeprilhydrochloride | |
| ATE297404T1 (de) | Verbessertes verfahren zur herstellung von bisphosphiten |