ATE368661T1 - Verfahren zur herstellung von 5-(4-fluorphenyl)-1- 2-((2r,4r)-4-hydroxy-6-oxo etrahydropyran-2- yl)ethylö-2-isopropyl-4-phenyl-1h-pyrrol-3- carbonsäurephenylamid - Google Patents
Verfahren zur herstellung von 5-(4-fluorphenyl)-1- 2-((2r,4r)-4-hydroxy-6-oxo etrahydropyran-2- yl)ethylö-2-isopropyl-4-phenyl-1h-pyrrol-3- carbonsäurephenylamidInfo
- Publication number
- ATE368661T1 ATE368661T1 AT03784362T AT03784362T ATE368661T1 AT E368661 T1 ATE368661 T1 AT E368661T1 AT 03784362 T AT03784362 T AT 03784362T AT 03784362 T AT03784362 T AT 03784362T AT E368661 T1 ATE368661 T1 AT E368661T1
- Authority
- AT
- Austria
- Prior art keywords
- ethylö
- etrahydropyran
- fluorophenyl
- pyrrole
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40170702P | 2002-08-06 | 2002-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368661T1 true ATE368661T1 (de) | 2007-08-15 |
Family
ID=31715723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03784362T ATE368661T1 (de) | 2002-08-06 | 2003-07-25 | Verfahren zur herstellung von 5-(4-fluorphenyl)-1- 2-((2r,4r)-4-hydroxy-6-oxo etrahydropyran-2- yl)ethylö-2-isopropyl-4-phenyl-1h-pyrrol-3- carbonsäurephenylamid |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6777560B2 (de) |
| EP (1) | EP1534704B1 (de) |
| JP (1) | JP2005539018A (de) |
| CN (1) | CN100357289C (de) |
| AR (1) | AR040777A1 (de) |
| AT (1) | ATE368661T1 (de) |
| AU (1) | AU2003247124A1 (de) |
| BR (1) | BR0313246A (de) |
| CA (1) | CA2494269A1 (de) |
| DE (1) | DE60315308T2 (de) |
| ES (1) | ES2287549T3 (de) |
| HK (1) | HK1077825A1 (de) |
| IL (1) | IL166119A0 (de) |
| MX (1) | MXPA05001427A (de) |
| PL (1) | PL375415A1 (de) |
| RS (1) | RS20050105A (de) |
| RU (1) | RU2279430C2 (de) |
| TW (1) | TW200413358A (de) |
| WO (1) | WO2004014896A1 (de) |
| ZA (1) | ZA200500049B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2494269A1 (en) * | 2002-08-06 | 2004-02-19 | Warner-Lambert Company Llc | Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide |
| WO2004089894A1 (en) * | 2003-04-14 | 2004-10-21 | Warner-Lambert Company Llc | Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide |
| JP4901474B2 (ja) | 2003-05-30 | 2012-03-21 | ランバクシー ラボラトリーズ リミテッド | 置換ピロール誘導体 |
| AU2006313430B2 (en) | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| JP4077863B1 (ja) | 2007-05-31 | 2008-04-23 | タヒボジャパン株式会社 | 抗癌活性を有する光学活性２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンの製法 |
| CN101205209B (zh) * | 2007-12-25 | 2010-06-02 | 浙江新东港药业股份有限公司 | 一种阿伐他汀中间体的精制方法 |
| WO2011028309A1 (en) | 2009-09-04 | 2011-03-10 | University Of Toledo | PROCESSES FOR PRODUCING OPTICALLY PURE β-LACTONES FROM ALDEHYDES AND COMPOSITIONS PRODUCED THEREBY |
| CN106083656B (zh) * | 2016-06-20 | 2018-11-13 | 连云港笃翔化工有限公司 | 一种地瑞那韦关键中间体的合成方法 |
| CN116496496A (zh) * | 2023-04-27 | 2023-07-28 | 中国石油大学(华东) | 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US509045A (en) * | 1893-11-21 | passburg | ||
| US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5216174A (en) | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| CZ294108B6 (cs) | 1995-07-17 | 2004-10-13 | Warner@Lambertácompany | Krystalická forma I hydrátu atorvastatinuŹ tj@ semivápenaté soli kyseliny [R@}RgŹRgB]@}@fluorfenylB@betaŹdelta@dihydroxy@Q@}�@methylethylB@fenyl[}fenylaminoBkarbonyl]@�H@pyrrol@�@heptanové |
| HRP960313B1 (en) | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| US6087511A (en) | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
| IL127058A (en) | 1996-07-29 | 2001-07-24 | Warner Lambert Co | Process for the synthesis of protected esters of acid (S) - 4,3 dehydroxybutyric |
| AU1058801A (en) * | 1999-10-18 | 2001-04-30 | Pohang University Of Science And Technology | Preparing method of chiral ester |
| US6476235B2 (en) | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| US6562201B2 (en) * | 2001-06-08 | 2003-05-13 | Applied Semiconductor, Inc. | Semiconductive polymeric system, devices incorporating the same, and its use in controlling corrosion |
| CA2494269A1 (en) * | 2002-08-06 | 2004-02-19 | Warner-Lambert Company Llc | Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide |
-
2003
- 2003-07-25 CA CA002494269A patent/CA2494269A1/en not_active Abandoned
- 2003-07-25 BR BR0313246-3A patent/BR0313246A/pt not_active IP Right Cessation
- 2003-07-25 WO PCT/IB2003/003322 patent/WO2004014896A1/en active IP Right Grant
- 2003-07-25 ES ES03784362T patent/ES2287549T3/es not_active Expired - Lifetime
- 2003-07-25 EP EP03784362A patent/EP1534704B1/de not_active Expired - Lifetime
- 2003-07-25 AU AU2003247124A patent/AU2003247124A1/en not_active Abandoned
- 2003-07-25 RU RU2005102839/04A patent/RU2279430C2/ru not_active IP Right Cessation
- 2003-07-25 CN CNB038186683A patent/CN100357289C/zh not_active Expired - Fee Related
- 2003-07-25 JP JP2004527174A patent/JP2005539018A/ja not_active Withdrawn
- 2003-07-25 AT AT03784362T patent/ATE368661T1/de not_active IP Right Cessation
- 2003-07-25 PL PL03375415A patent/PL375415A1/xx not_active Application Discontinuation
- 2003-07-25 RS YUP-2005/0105A patent/RS20050105A/sr unknown
- 2003-07-25 DE DE60315308T patent/DE60315308T2/de not_active Expired - Fee Related
- 2003-07-25 MX MXPA05001427A patent/MXPA05001427A/es active IP Right Grant
- 2003-08-04 AR AR20030102789A patent/AR040777A1/es unknown
- 2003-08-05 TW TW092121401A patent/TW200413358A/zh unknown
- 2003-08-06 US US10/635,317 patent/US6777560B2/en not_active Expired - Fee Related
-
2004
- 2004-06-08 US US10/863,899 patent/US7084282B2/en not_active Expired - Fee Related
-
2005
- 2005-01-03 IL IL16611905A patent/IL166119A0/xx unknown
- 2005-01-04 ZA ZA200500049A patent/ZA200500049B/en unknown
- 2005-11-08 HK HK05109934A patent/HK1077825A1/xx not_active IP Right Cessation
-
2006
- 2006-01-11 US US11/329,562 patent/US20060106228A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004014896A1 (en) | 2004-02-19 |
| DE60315308D1 (de) | 2007-09-13 |
| DE60315308T2 (de) | 2007-12-20 |
| EP1534704A1 (de) | 2005-06-01 |
| RU2005102839A (ru) | 2005-07-10 |
| JP2005539018A (ja) | 2005-12-22 |
| US6777560B2 (en) | 2004-08-17 |
| RU2279430C2 (ru) | 2006-07-10 |
| MXPA05001427A (es) | 2005-06-06 |
| CN100357289C (zh) | 2007-12-26 |
| US20040068121A1 (en) | 2004-04-08 |
| RS20050105A (en) | 2007-11-15 |
| US7084282B2 (en) | 2006-08-01 |
| CA2494269A1 (en) | 2004-02-19 |
| AU2003247124A1 (en) | 2004-02-25 |
| HK1077825A1 (en) | 2006-02-24 |
| IL166119A0 (en) | 2006-01-15 |
| ES2287549T3 (es) | 2007-12-16 |
| ZA200500049B (en) | 2006-07-26 |
| EP1534704B1 (de) | 2007-08-01 |
| BR0313246A (pt) | 2005-06-14 |
| TW200413358A (en) | 2004-08-01 |
| US20040220254A1 (en) | 2004-11-04 |
| US20060106228A1 (en) | 2006-05-18 |
| PL375415A1 (en) | 2005-11-28 |
| CN1675200A (zh) | 2005-09-28 |
| AR040777A1 (es) | 2005-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |