ATE453648T1 - Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol - Google Patents
Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-olInfo
- Publication number
- ATE453648T1 ATE453648T1 AT02797968T AT02797968T ATE453648T1 AT E453648 T1 ATE453648 T1 AT E453648T1 AT 02797968 T AT02797968 T AT 02797968T AT 02797968 T AT02797968 T AT 02797968T AT E453648 T1 ATE453648 T1 AT E453648T1
- Authority
- AT
- Austria
- Prior art keywords
- bufuran
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203416 | 2001-09-10 | ||
| PCT/EP2002/010062 WO2003022853A1 (en) | 2001-09-10 | 2002-09-06 | Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453648T1 true ATE453648T1 (de) | 2010-01-15 |
Family
ID=8180908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02797968T ATE453648T1 (de) | 2001-09-10 | 2002-09-06 | Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7126015B2 (de) |
| EP (1) | EP1448567B1 (de) |
| JP (1) | JP4521185B2 (de) |
| KR (1) | KR100894673B1 (de) |
| CN (2) | CN100519561C (de) |
| AP (1) | AP1758A (de) |
| AR (1) | AR036501A1 (de) |
| AT (1) | ATE453648T1 (de) |
| AU (1) | AU2002333809C1 (de) |
| BR (1) | BRPI0212341B8 (de) |
| CA (1) | CA2459168C (de) |
| CY (1) | CY1109974T1 (de) |
| DE (1) | DE60234952D1 (de) |
| DK (1) | DK1448567T3 (de) |
| EA (1) | EA010883B1 (de) |
| ES (1) | ES2338538T3 (de) |
| HR (1) | HRP20040320B1 (de) |
| HU (1) | HU229505B1 (de) |
| IL (2) | IL160166A0 (de) |
| MX (1) | MXPA04002247A (de) |
| NO (1) | NO328934B1 (de) |
| NZ (1) | NZ531641A (de) |
| PL (1) | PL224030B1 (de) |
| PT (1) | PT1448567E (de) |
| SI (1) | SI21463B (de) |
| WO (1) | WO2003022853A1 (de) |
| ZA (1) | ZA200401501B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1532127T3 (da) * | 2002-06-27 | 2007-02-05 | Smithkline Beecham Corp | Fremstilling af stereoisomerer af (3alfa,3alfa/beta,6alfa/beta)hexahydrofuro(2,3-b)furan-3-ol |
| AU2003275675A1 (en) * | 2002-12-27 | 2004-07-29 | Sumitomo Chemical Company, Limited | Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same |
| US7772411B2 (en) | 2003-12-23 | 2010-08-10 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
| TWI383975B (zh) * | 2004-03-31 | 2013-02-01 | 悌柏泰克醫藥有限公司 | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
| JP5549898B2 (ja) * | 2006-03-31 | 2014-07-16 | 独立行政法人産業技術総合研究所 | ５−ヒドロキシメチル−２−フルフラールの製造法 |
| WO2008055970A2 (en) | 2006-11-09 | 2008-05-15 | Tibotec Pharmaceuticals Ltd. | Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol |
| CN101024646B (zh) * | 2007-02-06 | 2010-07-14 | 启东东岳药业有限公司 | 4-甲氧基呋喃并呋喃-2-酮的纯化方法 |
| PL2152667T3 (pl) | 2007-04-27 | 2011-06-30 | Tibotec Pharm Ltd | Sposoby wytwarzania pochodnych N-izobutylo-N-(2-hydroksy-3-amino-4-fenylo-butylo)-p-nitrobenzenosulfonyloamidu |
| US8592487B2 (en) | 2007-10-26 | 2013-11-26 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
| AR073248A1 (es) | 2008-09-01 | 2010-10-20 | Tibotec Pharm Ltd | Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso. |
| WO2010047819A1 (en) * | 2008-10-24 | 2010-04-29 | Concert Pharmaceuticals, Inc. | Hydroxyethylamino sulfonamide derivatives |
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| US9062065B2 (en) | 2009-10-30 | 2015-06-23 | Lupin Limited | Process for preparation of darunavir and darunavir ethanolate of fine particle size |
| CN102725295A (zh) | 2010-01-28 | 2012-10-10 | Mapi医药公司 | 制备达芦那韦和达芦那韦中间体的方法 |
| WO2012070057A1 (en) | 2010-11-23 | 2012-05-31 | Matrix Laboratories Ltd | Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol |
| WO2012075122A2 (en) * | 2010-11-30 | 2012-06-07 | Purdue Research Foundation | Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans |
| ES2969589T3 (es) | 2012-07-24 | 2024-05-21 | Laurus Labs Ltd | Solvato de Propionato de Darunavir |
| ES2657227T3 (es) * | 2012-08-09 | 2018-03-02 | Sumitomo Chemical Company, Limited | Método para producir un derivado de hexahidrofurofuranol |
| CN103864813B (zh) * | 2012-12-18 | 2017-02-22 | 上海迪赛诺化学制药有限公司 | 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法 |
| EP3313847A4 (de) * | 2015-06-25 | 2019-04-24 | MSN Laboratories Private Limited | Verfahren zur herstellung von [(s 1,2r)-3-[[(4-aminophenyl) sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl) propyl]-carbaminsäure(3r,3as,6ar)hexahydro-furo[2,3-b]furan-3-yl-ester und dessen amorphe form |
| WO2017041228A1 (zh) * | 2015-09-08 | 2017-03-16 | 浙江九洲药业股份有限公司 | 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法 |
| CN110423228B (zh) * | 2016-02-05 | 2023-01-10 | 成都博腾药业有限公司 | 一种制备地瑞那韦中间体的方法 |
| EP3532478B1 (de) | 2016-10-27 | 2021-05-26 | Gilead Sciences, Inc. | Crystalline form von darunavir freie base |
| CN106928248B (zh) * | 2017-02-04 | 2019-01-04 | 青岛科技大学 | 一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法 |
| CN116103348A (zh) | 2018-03-16 | 2023-05-12 | 江苏瑞科医药科技有限公司 | 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法 |
| WO2022035499A1 (en) * | 2020-08-11 | 2022-02-17 | Ghosh Arun K | Methods for making darunavir p2-ligand precursors |
| CN114853774A (zh) * | 2022-06-24 | 2022-08-05 | 盐城迪赛诺制药有限公司 | 一种达卢那韦关键中间体的制备方法 |
| CN115557964A (zh) * | 2022-10-18 | 2023-01-03 | 启东东岳药业有限公司 | 一种药物化合物的制备方法 |
| CN117186053A (zh) * | 2023-09-08 | 2023-12-08 | 上海凌凯医药科技有限公司 | 一种莱克酮中间体的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4325970A (en) * | 1980-10-09 | 1982-04-20 | Hoffmann-La Roche Inc. | 15-Acetyl-prostaglandins |
| NZ224497A (en) * | 1987-05-18 | 1990-04-26 | Janssen Pharmaceutica Nv | Pharmaceutical composition comprising flunarizine |
| US5281420A (en) * | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| AU6828894A (en) * | 1993-05-14 | 1994-12-12 | Merck & Co., Inc. | Hiv protease inhibitors |
| AU7669794A (en) | 1993-08-24 | 1995-03-21 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| RU2089545C1 (ru) * | 1994-09-28 | 1997-09-10 | Ярославский государственный технический университет | Способ получения 2-метил-2-этил-1,3-диоксолан-4-ил-метилметакрилата |
| DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19638020A1 (de) * | 1996-09-18 | 1998-03-19 | Solvay Pharm Gmbh | Die gastrointestinale Durchblutung fördernde Arzneimittel |
| AU737053B2 (en) * | 1997-01-30 | 2001-08-09 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
| AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
| ES2604662T3 (es) * | 1998-06-23 | 2017-03-08 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Ensayo de acondicionamiento físico y métodos para reducir la resistencia del VIH a la terapia |
| KR100336090B1 (ko) * | 1998-06-27 | 2002-05-27 | 윤승원 | 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제 |
| DE19906310A1 (de) * | 1999-02-16 | 2000-08-17 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von Bluthochdruck |
| DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
| OA12053A (en) * | 1999-10-06 | 2006-05-02 | Tibotec Pharm Ltd | HexahydrofuroÄ2,3-bÜfuran-3-yl-N-ä3-Ä(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)aminoÜ-1-benzyl-2-hydroxypropylücarbamate as retroviral protease inhibitor. |
-
2002
- 2002-09-06 JP JP2003526927A patent/JP4521185B2/ja not_active Expired - Lifetime
- 2002-09-06 DE DE60234952T patent/DE60234952D1/de not_active Expired - Lifetime
- 2002-09-06 DK DK02797968.1T patent/DK1448567T3/da active
- 2002-09-06 AU AU2002333809A patent/AU2002333809C1/en not_active Expired
- 2002-09-06 CN CNB028176391A patent/CN100519561C/zh not_active Expired - Lifetime
- 2002-09-06 EA EA200400430A patent/EA010883B1/ru not_active IP Right Cessation
- 2002-09-06 CN CN200710186668XA patent/CN101172980B/zh not_active Expired - Lifetime
- 2002-09-06 AT AT02797968T patent/ATE453648T1/de active
- 2002-09-06 SI SI200220026A patent/SI21463B/sl active Search and Examination
- 2002-09-06 IL IL16016602A patent/IL160166A0/xx unknown
- 2002-09-06 AP APAP/P/2004/002981A patent/AP1758A/en active
- 2002-09-06 MX MXPA04002247A patent/MXPA04002247A/es active IP Right Grant
- 2002-09-06 US US10/489,059 patent/US7126015B2/en not_active Expired - Lifetime
- 2002-09-06 PT PT02797968T patent/PT1448567E/pt unknown
- 2002-09-06 BR BRPI0212341A patent/BRPI0212341B8/pt not_active IP Right Cessation
- 2002-09-06 CA CA2459168A patent/CA2459168C/en not_active Expired - Lifetime
- 2002-09-06 HR HRP20040320AA patent/HRP20040320B1/hr not_active IP Right Cessation
- 2002-09-06 ES ES02797968T patent/ES2338538T3/es not_active Expired - Lifetime
- 2002-09-06 EP EP02797968A patent/EP1448567B1/de not_active Expired - Lifetime
- 2002-09-06 NZ NZ531641A patent/NZ531641A/en not_active IP Right Cessation
- 2002-09-06 KR KR1020047002113A patent/KR100894673B1/ko not_active Expired - Lifetime
- 2002-09-06 HU HU0402140A patent/HU229505B1/hu unknown
- 2002-09-06 PL PL367817A patent/PL224030B1/pl unknown
- 2002-09-06 WO PCT/EP2002/010062 patent/WO2003022853A1/en not_active Ceased
- 2002-09-09 AR ARP020103403A patent/AR036501A1/es active IP Right Grant
-
2004
- 2004-02-02 IL IL160166A patent/IL160166A/en active IP Right Grant
- 2004-02-24 ZA ZA2004/01501A patent/ZA200401501B/en unknown
- 2004-04-06 NO NO20041434A patent/NO328934B1/no not_active IP Right Cessation
-
2010
- 2010-03-30 CY CY20101100296T patent/CY1109974T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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