DE60234952D1 - VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL - Google Patents

VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL

Info

Publication number
DE60234952D1
DE60234952D1 DE60234952T DE60234952T DE60234952D1 DE 60234952 D1 DE60234952 D1 DE 60234952D1 DE 60234952 T DE60234952 T DE 60234952T DE 60234952 T DE60234952 T DE 60234952T DE 60234952 D1 DE60234952 D1 DE 60234952D1
Authority
DE
Germany
Prior art keywords
büfuran
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234952T
Other languages
English (en)
Inventor
Bart Rudolf Kesteleyn
Dominique Louis Surleraux
Peter J L M Quaedflieg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen R&D Ireland ULC
Original Assignee
Tibotec Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60234952(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd
Application granted granted Critical
Publication of DE60234952D1 publication Critical patent/DE60234952D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE60234952T 2001-09-10 2002-09-06 VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL Expired - Lifetime DE60234952D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203416 2001-09-10
PCT/EP2002/010062 WO2003022853A1 (en) 2001-09-10 2002-09-06 Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Publications (1)

Publication Number Publication Date
DE60234952D1 true DE60234952D1 (de) 2010-02-11

Family

ID=8180908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60234952T Expired - Lifetime DE60234952D1 (de) 2001-09-10 2002-09-06 VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL

Country Status (28)

Country Link
US (1) US7126015B2 (de)
EP (1) EP1448567B1 (de)
JP (1) JP4521185B2 (de)
KR (1) KR100894673B1 (de)
CN (2) CN100519561C (de)
AP (1) AP1758A (de)
AR (1) AR036501A1 (de)
AT (1) ATE453648T1 (de)
AU (1) AU2002333809C1 (de)
BR (1) BRPI0212341B8 (de)
CA (1) CA2459168C (de)
CY (1) CY1109974T1 (de)
DE (1) DE60234952D1 (de)
DK (1) DK1448567T3 (de)
EA (1) EA010883B1 (de)
ES (1) ES2338538T3 (de)
HK (1) HK1068887A1 (de)
HR (1) HRP20040320B1 (de)
HU (1) HU229505B1 (de)
IL (2) IL160166A0 (de)
MX (1) MXPA04002247A (de)
NO (1) NO328934B1 (de)
NZ (1) NZ531641A (de)
PL (1) PL224030B1 (de)
PT (1) PT1448567E (de)
SI (1) SI21463B (de)
WO (1) WO2003022853A1 (de)
ZA (1) ZA200401501B (de)

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PT1532127E (pt) * 2002-06-27 2007-01-31 Smithkline Beecham Corp Preparação de estereoisómeros de ( 3alfa, 3alfa/beta, 6alfa/beta )hexa-hidrofuro ( 2,3-b ) furan-3-ol
AU2003275675A1 (en) * 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
ME01059B (me) 2003-12-23 2012-10-20 Janssen Sciences Ireland Uc Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata
TWI383975B (zh) * 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
JP5549898B2 (ja) * 2006-03-31 2014-07-16 独立行政法人産業技術総合研究所 ５−ヒドロキシメチル−２−フルフラールの製造法
CN101541775B (zh) * 2006-11-09 2011-12-28 泰博特克药品有限公司 六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
BRPI0810609A2 (pt) 2007-04-27 2014-10-21 Tibotec Pharm Ltd Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US20110257111A1 (en) * 2008-10-24 2011-10-20 Harbeson Scott L Hydroxyethlamino Sulfonamide Derivatives
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
BR112012009956A2 (pt) 2009-10-30 2015-09-29 Lupin Ltd um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula.
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
US8841467B2 (en) 2010-11-23 2014-09-23 Mylan Laboratories Limited Process for the preparation of (3R, 3aS, 6aR)-hexahydrofuro [2, 3-b] furan-3-ol
US8802724B2 (en) 2010-11-30 2014-08-12 Purdue Research Foundation Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
ES2848216T3 (es) 2012-07-24 2021-08-05 Laurus Labs Ltd Un proceso para la preparación de Darunavir
JPWO2014024898A1 (ja) * 2012-08-09 2016-07-25 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
US10633390B2 (en) * 2015-06-25 2020-04-28 Msn Laboratories Private Limited Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN110423228B (zh) * 2016-02-05 2023-01-10 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
EP3532478B1 (de) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form von darunavir freie base
CN106928248B (zh) * 2017-02-04 2019-01-04 青岛科技大学 一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法
CN110272398B (zh) 2018-03-16 2022-11-29 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN114853774A (zh) * 2022-06-24 2022-08-05 盐城迪赛诺制药有限公司 一种达卢那韦关键中间体的制备方法
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法

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US4325970A (en) * 1980-10-09 1982-04-20 Hoffmann-La Roche Inc. 15-Acetyl-prostaglandins
NZ224497A (en) * 1987-05-18 1990-04-26 Janssen Pharmaceutica Nv Pharmaceutical composition comprising flunarizine
US5281420A (en) * 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
AU6828894A (en) * 1993-05-14 1994-12-12 Merck & Co., Inc. Hiv protease inhibitors
DE69415326T2 (de) 1993-08-24 1999-06-02 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
RU2089545C1 (ru) * 1994-09-28 1997-09-10 Ярославский государственный технический университет Способ получения 2-метил-2-этил-1,3-диоксолан-4-ил-метилметакрилата
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
RU2211047C2 (ru) * 1997-01-30 2003-08-27 Новартис Аг Желатиновые капсулы с твердым покрытием, включающие фармацевтические композиции, практически не содержащие масел
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
CA2872424C (en) 1998-06-23 2017-03-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Bisfuran derivatives useful in preventing the emergence of multidrug resistant hiv strains and treatment of hiv
KR100336090B1 (ko) * 1998-06-27 2002-05-27 윤승원 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
HU228938B1 (hu) * 1999-10-06 2013-06-28 Us Government Hexahidrofuro[2,3-b]furán-3-il-N-{3-(1,3-benzodioxol-5-il-szulfonil)-(izobutil)-amino-1-benzil-2- -(hidroxi-propil)}-karbamát mint retrovírus proteáz gátló

Also Published As

Publication number Publication date
EA200400430A1 (ru) 2004-08-26
HK1068887A1 (en) 2005-05-06
ATE453648T1 (de) 2010-01-15
JP2005502707A (ja) 2005-01-27
CN1553915A (zh) 2004-12-08
AU2002333809B8 (en) 2008-07-03
HRP20040320B1 (hr) 2012-11-30
BRPI0212341B8 (pt) 2021-05-25
WO2003022853A1 (en) 2003-03-20
ES2338538T3 (es) 2010-05-10
CN101172980A (zh) 2008-05-07
MXPA04002247A (es) 2005-09-07
CA2459168C (en) 2014-01-28
SI21463B (sl) 2011-08-31
HUP0402140A2 (hu) 2005-02-28
US7126015B2 (en) 2006-10-24
EA010883B1 (ru) 2008-12-30
HU229505B1 (hu) 2014-01-28
CN101172980B (zh) 2011-11-16
PL367817A1 (en) 2005-03-07
JP4521185B2 (ja) 2010-08-11
DK1448567T3 (da) 2010-04-26
SI21463A (sl) 2004-10-31
NZ531641A (en) 2005-08-26
BRPI0212341B1 (pt) 2019-04-02
HUP0402140A3 (en) 2007-05-29
IL160166A0 (en) 2004-07-25
EP1448567A1 (de) 2004-08-25
NO328934B1 (no) 2010-06-21
KR100894673B1 (ko) 2009-04-24
AU2002333809B2 (en) 2008-02-28
ZA200401501B (en) 2005-07-27
AU2002333809B9 (en) 2008-06-26
NO20041434L (no) 2004-06-10
BR0212341A (pt) 2004-07-27
AU2002333809C1 (en) 2009-02-05
AP2004002981A0 (en) 2004-03-31
IL160166A (en) 2012-05-31
EP1448567B1 (de) 2009-12-30
HRP20040320A2 (en) 2005-04-30
KR20040029425A (ko) 2004-04-06
AP1758A (en) 2007-07-30
PL224030B1 (pl) 2016-11-30
PT1448567E (pt) 2010-03-12
CY1109974T1 (el) 2014-09-10
CN100519561C (zh) 2009-07-29
AR036501A1 (es) 2004-09-15
US20040249175A1 (en) 2004-12-09
CA2459168A1 (en) 2003-03-20

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