BRPI0212341B8 - compostos intermediários de inibidores de protease de hiv e processo para preparação dos mesmos - Google Patents

compostos intermediários de inibidores de protease de hiv e processo para preparação dos mesmos

Info

Publication number
BRPI0212341B8
BRPI0212341B8 BRPI0212341A BR0212341A BRPI0212341B8 BR PI0212341 B8 BRPI0212341 B8 BR PI0212341B8 BR PI0212341 A BRPI0212341 A BR PI0212341A BR 0212341 A BR0212341 A BR 0212341A BR PI0212341 B8 BRPI0212341 B8 BR PI0212341B8
Authority
BR
Brazil
Prior art keywords
preparing
intermediate compounds
hiv protease
same
protease inhibitors
Prior art date
Application number
BRPI0212341A
Other languages
English (en)
Other versions
BRPI0212341B1 (pt
BR0212341A (pt
Inventor
Rudolf Romanie Kesteleyn Bart
Louis Nestor Ghislain Surleraux Dominique
Jan Leonard Mario Quaedflieg Peter
Original Assignee
Janssen R&D Ireland
Janssen Sciences Ireland Uc
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0212341(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R&D Ireland, Janssen Sciences Ireland Uc, Tibotec Pharm Ltd filed Critical Janssen R&D Ireland
Publication of BR0212341A publication Critical patent/BR0212341A/pt
Publication of BRPI0212341B1 publication Critical patent/BRPI0212341B1/pt
Publication of BRPI0212341B8 publication Critical patent/BRPI0212341B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

inibidor de protease de hiv, compostos intermediários e processo para preparação dos mesmos. a presente invenção refere-se a um método para preparação de hexaidro-furo[2,3-b]furan-3-ol, bem como novos intermediários para uso no método. mais especificamente, a invenção refere-se a um método estereosseletivo para a preparação de hexaidro-furo[2,3-b]furan-3-ol e a um método receptível em escala industrial.
BRPI0212341A 2001-09-10 2002-09-06 compostos intermediários de inibidores de protease de hiv e processo para preparação dos mesmos BRPI0212341B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203416 2001-09-10
EP01203416.1 2001-09-10
PCT/EP2002/010062 WO2003022853A1 (en) 2001-09-10 2002-09-06 Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Publications (3)

Publication Number Publication Date
BR0212341A BR0212341A (pt) 2004-07-27
BRPI0212341B1 BRPI0212341B1 (pt) 2019-04-02
BRPI0212341B8 true BRPI0212341B8 (pt) 2021-05-25

Family

ID=8180908

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0212341A BRPI0212341B8 (pt) 2001-09-10 2002-09-06 compostos intermediários de inibidores de protease de hiv e processo para preparação dos mesmos

Country Status (28)

Country Link
US (1) US7126015B2 (pt)
EP (1) EP1448567B1 (pt)
JP (1) JP4521185B2 (pt)
KR (1) KR100894673B1 (pt)
CN (2) CN100519561C (pt)
AP (1) AP1758A (pt)
AR (1) AR036501A1 (pt)
AT (1) ATE453648T1 (pt)
AU (1) AU2002333809C1 (pt)
BR (1) BRPI0212341B8 (pt)
CA (1) CA2459168C (pt)
CY (1) CY1109974T1 (pt)
DE (1) DE60234952D1 (pt)
DK (1) DK1448567T3 (pt)
EA (1) EA010883B1 (pt)
ES (1) ES2338538T3 (pt)
HK (1) HK1068887A1 (pt)
HR (1) HRP20040320B1 (pt)
HU (1) HU229505B1 (pt)
IL (2) IL160166A0 (pt)
MX (1) MXPA04002247A (pt)
NO (1) NO328934B1 (pt)
NZ (1) NZ531641A (pt)
PL (1) PL224030B1 (pt)
PT (1) PT1448567E (pt)
SI (1) SI21463B (pt)
WO (1) WO2003022853A1 (pt)
ZA (1) ZA200401501B (pt)

Families Citing this family (27)

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ATE340788T1 (de) * 2002-06-27 2006-10-15 Smithkline Beecham Corp Herstellung von stereoisomeren von (3alpha, 3alpha/beta, 6alpha/beta)hexahydrofuro(2,3- böfuran-3-ol
WO2004060895A1 (ja) * 2002-12-27 2004-07-22 Sumitomo Chemical Company, Limited ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
JP5549898B2 (ja) * 2006-03-31 2014-07-16 独立行政法人産業技術総合研究所 ５−ヒドロキシメチル−２−フルフラールの製造法
BRPI0718706B8 (pt) 2006-11-09 2021-05-25 Janssen R & D Ireland métodos para a preparação de hexa-hidrofuro[2,3- b]furan-3-ol
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
EP2152667B1 (en) 2007-04-27 2011-02-16 Tibotec Pharmaceuticals Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
EP2358198A4 (en) * 2008-10-24 2012-11-14 Concert Pharmaceuticals Inc HYDROXYETHYLAMINO SULFONAMIDE DERIVATIVES
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
AU2010313085A1 (en) 2009-10-30 2012-05-31 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
ES2607279T3 (es) 2010-11-23 2017-03-29 Mylan Laboratories, Limited Procedimiento para la preparación de (3R,3aS,6aR)-hexahidrofuro[2,3-b]furan-3-ol
WO2012075122A2 (en) * 2010-11-30 2012-06-07 Purdue Research Foundation Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
WO2014016660A2 (en) 2012-07-24 2014-01-30 Laurus Labs Private Limited A process for preparation of darunavir
WO2014024898A1 (ja) * 2012-08-09 2014-02-13 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
EP3313847A4 (en) * 2015-06-25 2019-04-24 MSN Laboratories Private Limited PROCESS FOR PREPARING (3R, 3AS, 6AR) HEXAHYDROFURO [2,3-B] FURAN-3-YL ESTER OF [(1S, 2R) -3 - [[(4-AMINOPHENYL) SULFONYL] (2-METHYLPROPYL) ACID ) AMINO] -2-HYDROXY-1- (PHENYLMETHYL) PROPYL] -CARBAMIC AND ITS AMORPHOUS FORM
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN110423228B (zh) * 2016-02-05 2023-01-10 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
CN106928248B (zh) * 2017-02-04 2019-01-04 青岛科技大学 一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法
CN110272398B (zh) 2018-03-16 2022-11-29 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN114853774A (zh) * 2022-06-24 2022-08-05 盐城迪赛诺制药有限公司 一种达卢那韦关键中间体的制备方法
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法

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AU6828894A (en) * 1993-05-14 1994-12-12 Merck & Co., Inc. Hiv protease inhibitors
DE69415326T2 (de) 1993-08-24 1999-06-02 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
RU2089545C1 (ru) * 1994-09-28 1997-09-10 Ярославский государственный технический университет Способ получения 2-метил-2-этил-1,3-диоксолан-4-ил-метилметакрилата
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
IL130797A0 (en) * 1997-01-30 2001-01-28 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
CA2872424C (en) * 1998-06-23 2017-03-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Bisfuran derivatives useful in preventing the emergence of multidrug resistant hiv strains and treatment of hiv
KR100336090B1 (ko) * 1998-06-27 2002-05-27 윤승원 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
CA2386850C (en) * 1999-10-06 2010-03-30 Piet Tom Bert Paul Wigerinck Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor

Also Published As

Publication number Publication date
ATE453648T1 (de) 2010-01-15
NO328934B1 (no) 2010-06-21
ES2338538T3 (es) 2010-05-10
HUP0402140A2 (hu) 2005-02-28
US7126015B2 (en) 2006-10-24
IL160166A (en) 2012-05-31
CN101172980A (zh) 2008-05-07
HUP0402140A3 (en) 2007-05-29
CN1553915A (zh) 2004-12-08
AU2002333809B9 (en) 2008-06-26
PT1448567E (pt) 2010-03-12
EP1448567A1 (en) 2004-08-25
EA200400430A1 (ru) 2004-08-26
AP1758A (en) 2007-07-30
AU2002333809B2 (en) 2008-02-28
SI21463B (sl) 2011-08-31
AU2002333809C1 (en) 2009-02-05
WO2003022853A1 (en) 2003-03-20
CN100519561C (zh) 2009-07-29
AR036501A1 (es) 2004-09-15
ZA200401501B (en) 2005-07-27
HK1068887A1 (en) 2005-05-06
KR100894673B1 (ko) 2009-04-24
CA2459168C (en) 2014-01-28
HRP20040320A2 (en) 2005-04-30
JP4521185B2 (ja) 2010-08-11
DE60234952D1 (de) 2010-02-11
US20040249175A1 (en) 2004-12-09
BRPI0212341B1 (pt) 2019-04-02
PL224030B1 (pl) 2016-11-30
EP1448567B1 (en) 2009-12-30
CY1109974T1 (el) 2014-09-10
NZ531641A (en) 2005-08-26
PL367817A1 (en) 2005-03-07
NO20041434L (no) 2004-06-10
CN101172980B (zh) 2011-11-16
MXPA04002247A (es) 2005-09-07
HRP20040320B1 (hr) 2012-11-30
CA2459168A1 (en) 2003-03-20
IL160166A0 (en) 2004-07-25
BR0212341A (pt) 2004-07-27
AU2002333809B8 (en) 2008-07-03
EA010883B1 (ru) 2008-12-30
AP2004002981A0 (en) 2004-03-31
SI21463A (sl) 2004-10-31
DK1448567T3 (da) 2010-04-26
JP2005502707A (ja) 2005-01-27
HU229505B1 (hu) 2014-01-28
KR20040029425A (ko) 2004-04-06

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