AR040777A1 - Procedimiento para preparar fenilamida del acido 5-( 4-fluorofenil)-1-(2((2r,4r)-4-hidroxi-6-oxo-tetrahidro-piran-2il) etil) -2-isopropil-4-fenil-1-h-pirrol-3- carboxilico - Google Patents
Procedimiento para preparar fenilamida del acido 5-( 4-fluorofenil)-1-(2((2r,4r)-4-hidroxi-6-oxo-tetrahidro-piran-2il) etil) -2-isopropil-4-fenil-1-h-pirrol-3- carboxilicoInfo
- Publication number
- AR040777A1 AR040777A1 AR20030102789A ARP030102789A AR040777A1 AR 040777 A1 AR040777 A1 AR 040777A1 AR 20030102789 A AR20030102789 A AR 20030102789A AR P030102789 A ARP030102789 A AR P030102789A AR 040777 A1 AR040777 A1 AR 040777A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- carboxilico
- isopropil
- pirrol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Reivindicación 1: Un procedimiento para la preparación de un compuesto de fórmula (1) que comprende (a) poner en contacto en un disolvente un compuesto de fórmula (2) con un catalizador de un metal de transición, una fuente de H y una base para proporcionar un compuesto de fórmula (3); en donde R1 se define como -XR, en donde X es O; S o Se, o R1 es R3-N-R2, en donde R2 y R3 son, independientemente, alquilo, cicloalquilo, arilalquilo, o arilo, o R2 y R3 tomados juntos son -(CH2)4-, -(CH2)5-, -(CH(R4)-CH2)3-, -(CH(R4)-CH2)4-, -(CH(R4)-CH2)2-CH(R4))-, -(CH(R4)-CH2)3-CH(R4))-, -CH2-CH2-A-CH2-CH2-, -CH(R4)-CH2-A-CH2-CH2-, -CH(R4)-CH2-A-CH2-CH(R4)-, en donde R4 es alquilo de uno a cuatro átomos de carbono, A es O, S o N, y R se define como alquilo, arilo, arilalquilo o heteroarilo; y( b) conversión del compuesto de fórmula (3), en donde R1 es como se ha definido anteriormente, en un compuesto de fórmula (4) usando una base en metanol acuoso; y (c) poner en contacto en un disolvente el compuesto de fórmula (4) con un ácido para proporcionar un compuesto de fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40170702P | 2002-08-06 | 2002-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040777A1 true AR040777A1 (es) | 2005-04-20 |
Family
ID=31715723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR20030102789A AR040777A1 (es) | 2002-08-06 | 2003-08-04 | Procedimiento para preparar fenilamida del acido 5-( 4-fluorofenil)-1-(2((2r,4r)-4-hidroxi-6-oxo-tetrahidro-piran-2il) etil) -2-isopropil-4-fenil-1-h-pirrol-3- carboxilico |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6777560B2 (es) |
| EP (1) | EP1534704B1 (es) |
| JP (1) | JP2005539018A (es) |
| CN (1) | CN100357289C (es) |
| AR (1) | AR040777A1 (es) |
| AT (1) | ATE368661T1 (es) |
| AU (1) | AU2003247124A1 (es) |
| BR (1) | BR0313246A (es) |
| CA (1) | CA2494269A1 (es) |
| DE (1) | DE60315308T2 (es) |
| ES (1) | ES2287549T3 (es) |
| HK (1) | HK1077825A1 (es) |
| IL (1) | IL166119A0 (es) |
| MX (1) | MXPA05001427A (es) |
| PL (1) | PL375415A1 (es) |
| RS (1) | RS20050105A (es) |
| RU (1) | RU2279430C2 (es) |
| TW (1) | TW200413358A (es) |
| WO (1) | WO2004014896A1 (es) |
| ZA (1) | ZA200500049B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100357289C (zh) * | 2002-08-06 | 2007-12-26 | 沃尼尔·朗伯有限责任公司 | 制备5－(4－氟苯基)－1－[2－((2r,4r)－4－羟基－6－氧代－四氢－吡喃－2－基)乙基]－2－异丙基－4－苯基－1h－吡咯－3－羧酸苯基酰胺的方法 |
| KR100780984B1 (ko) * | 2003-04-14 | 2007-11-29 | 워너-램버트 캄파니 엘엘씨 | 5-(4-플루오로페닐)-1-[2-((2ｒ,4ｒ)-4-히드록시-6-옥소-테트라히드로-피란-2-일)에틸]-2-이소프로필-4-페닐-1ｈ-피롤-3-카르복실산 페닐아미드의 제조 방법 |
| NZ543741A (en) | 2003-05-30 | 2009-10-30 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as HMG-Co inhibitors |
| US8026377B2 (en) | 2005-11-08 | 2011-09-27 | Ranbaxy Laboratories, Limited | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
| JP4077863B1 (ja) | 2007-05-31 | 2008-04-23 | タヒボジャパン株式会社 | 抗癌活性を有する光学活性２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンの製法 |
| CN101205209B (zh) * | 2007-12-25 | 2010-06-02 | 浙江新东港药业股份有限公司 | 一种阿伐他汀中间体的精制方法 |
| US9334266B2 (en) | 2009-09-04 | 2016-05-10 | The University Of Toledo | Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby |
| CN106083656B (zh) * | 2016-06-20 | 2018-11-13 | 连云港笃翔化工有限公司 | 一种地瑞那韦关键中间体的合成方法 |
| US12027979B2 (en) | 2020-06-10 | 2024-07-02 | Apple Inc. | Battery path impedance compensation |
| CN116496496A (zh) * | 2023-04-27 | 2023-07-28 | 中国石油大学(华东) | 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US509045A (en) * | 1893-11-21 | passburg | ||
| US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5216174A (en) | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
| US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| WO1997003959A1 (en) | 1995-07-17 | 1997-02-06 | Warner-Lambert Company | Crystalline [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) |
| HRP960313B1 (en) | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| US6087511A (en) | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
| IL127058A (en) | 1996-07-29 | 2001-07-24 | Warner Lambert Co | Process for the synthesis of protected esters of acid (S) - 4,3 dehydroxybutyric |
| US6753443B1 (en) * | 1999-10-18 | 2004-06-22 | Samsung Fine Chemicals Co., Ltd. | Preparing method of chiral ester |
| US6476235B2 (en) | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| US6562201B2 (en) * | 2001-06-08 | 2003-05-13 | Applied Semiconductor, Inc. | Semiconductive polymeric system, devices incorporating the same, and its use in controlling corrosion |
| CN100357289C (zh) * | 2002-08-06 | 2007-12-26 | 沃尼尔·朗伯有限责任公司 | 制备5－(4－氟苯基)－1－[2－((2r,4r)－4－羟基－6－氧代－四氢－吡喃－2－基)乙基]－2－异丙基－4－苯基－1h－吡咯－3－羧酸苯基酰胺的方法 |
-
2003
- 2003-07-25 CN CNB038186683A patent/CN100357289C/zh not_active Expired - Fee Related
- 2003-07-25 AU AU2003247124A patent/AU2003247124A1/en not_active Abandoned
- 2003-07-25 ES ES03784362T patent/ES2287549T3/es not_active Expired - Lifetime
- 2003-07-25 CA CA002494269A patent/CA2494269A1/en not_active Abandoned
- 2003-07-25 DE DE60315308T patent/DE60315308T2/de not_active Expired - Fee Related
- 2003-07-25 RU RU2005102839/04A patent/RU2279430C2/ru not_active IP Right Cessation
- 2003-07-25 PL PL03375415A patent/PL375415A1/xx not_active Application Discontinuation
- 2003-07-25 JP JP2004527174A patent/JP2005539018A/ja not_active Withdrawn
- 2003-07-25 WO PCT/IB2003/003322 patent/WO2004014896A1/en active IP Right Grant
- 2003-07-25 RS YUP-2005/0105A patent/RS20050105A/sr unknown
- 2003-07-25 BR BR0313246-3A patent/BR0313246A/pt not_active IP Right Cessation
- 2003-07-25 MX MXPA05001427A patent/MXPA05001427A/es active IP Right Grant
- 2003-07-25 EP EP03784362A patent/EP1534704B1/en not_active Expired - Lifetime
- 2003-07-25 AT AT03784362T patent/ATE368661T1/de not_active IP Right Cessation
- 2003-08-04 AR AR20030102789A patent/AR040777A1/es unknown
- 2003-08-05 TW TW092121401A patent/TW200413358A/zh unknown
- 2003-08-06 US US10/635,317 patent/US6777560B2/en not_active Expired - Fee Related
-
2004
- 2004-06-08 US US10/863,899 patent/US7084282B2/en not_active Expired - Fee Related
-
2005
- 2005-01-03 IL IL16611905A patent/IL166119A0/xx unknown
- 2005-01-04 ZA ZA200500049A patent/ZA200500049B/en unknown
- 2005-11-08 HK HK05109934A patent/HK1077825A1/xx not_active IP Right Cessation
-
2006
- 2006-01-11 US US11/329,562 patent/US20060106228A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2279430C2 (ru) | 2006-07-10 |
| IL166119A0 (en) | 2006-01-15 |
| RS20050105A (en) | 2007-11-15 |
| DE60315308T2 (de) | 2007-12-20 |
| HK1077825A1 (en) | 2006-02-24 |
| WO2004014896A1 (en) | 2004-02-19 |
| US20040220254A1 (en) | 2004-11-04 |
| BR0313246A (pt) | 2005-06-14 |
| PL375415A1 (en) | 2005-11-28 |
| CA2494269A1 (en) | 2004-02-19 |
| US7084282B2 (en) | 2006-08-01 |
| ZA200500049B (en) | 2006-07-26 |
| JP2005539018A (ja) | 2005-12-22 |
| ATE368661T1 (de) | 2007-08-15 |
| RU2005102839A (ru) | 2005-07-10 |
| CN100357289C (zh) | 2007-12-26 |
| US6777560B2 (en) | 2004-08-17 |
| US20040068121A1 (en) | 2004-04-08 |
| US20060106228A1 (en) | 2006-05-18 |
| DE60315308D1 (de) | 2007-09-13 |
| MXPA05001427A (es) | 2005-06-06 |
| ES2287549T3 (es) | 2007-12-16 |
| CN1675200A (zh) | 2005-09-28 |
| EP1534704A1 (en) | 2005-06-01 |
| EP1534704B1 (en) | 2007-08-01 |
| AU2003247124A1 (en) | 2004-02-25 |
| TW200413358A (en) | 2004-08-01 |
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