ATE443064T1 - 10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterien - Google Patents
10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterienInfo
- Publication number
- ATE443064T1 ATE443064T1 AT03708575T AT03708575T ATE443064T1 AT E443064 T1 ATE443064 T1 AT E443064T1 AT 03708575 T AT03708575 T AT 03708575T AT 03708575 T AT03708575 T AT 03708575T AT E443064 T1 ATE443064 T1 AT E443064T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- resistant bacteria
- pyridobenzoxazine
- pyrrolidinyl
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title abstract 2
- WZGXGRXTBAEETD-UHFFFAOYSA-N 10-[3-[(cyclopropylamino)methyl]pyrrolidin-1-yl]-2h-pyrido[2,3-h][1,2]benzoxazine-3-carboxylic acid Chemical class C12=C3ONC(C(=O)O)=CC3=CC=C2N=CC=C1N(C1)CCC1CNC1CC1 WZGXGRXTBAEETD-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 102100025142 Beta-microseminoprotein Human genes 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 101100185029 Homo sapiens MSMB gene Proteins 0.000 abstract 1
- -1 acetoxymethyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002074783 | 2002-03-18 | ||
| JP2002369205 | 2002-12-20 | ||
| PCT/JP2003/002967 WO2003078439A1 (en) | 2002-03-18 | 2003-03-13 | 10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443064T1 true ATE443064T1 (de) | 2009-10-15 |
Family
ID=28043757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03708575T ATE443064T1 (de) | 2002-03-18 | 2003-03-13 | 10-(3-cyclo propyl amino methyl-1-pyrrolidinyl) pyridobenzoxazin carbonsäure derivat mit wirkung gegen resistente bakterien |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7153851B2 (de) |
| EP (1) | EP1486500B1 (de) |
| JP (1) | JP4468701B2 (de) |
| KR (1) | KR20040094806A (de) |
| CN (1) | CN1653071A (de) |
| AT (1) | ATE443064T1 (de) |
| AU (1) | AU2003213335B8 (de) |
| BR (1) | BR0308643A (de) |
| CA (1) | CA2478763A1 (de) |
| DE (1) | DE60329280D1 (de) |
| MX (1) | MXPA04009026A (de) |
| NO (1) | NO20043850L (de) |
| NZ (1) | NZ535182A (de) |
| WO (1) | WO2003078439A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG144936A1 (en) * | 2003-09-10 | 2008-08-28 | Kyorin Seiyaku Kk | 7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| WO2006009143A1 (ja) * | 2004-07-21 | 2006-01-26 | Kyorin Pharmaceutical Co., Ltd. | （３ｓ）－３－ヒドロキシメチル－７－オキソピリドベンゾオキサジン－６－カルボン酸エステルの製造方法 |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| JP5154402B2 (ja) * | 2006-03-09 | 2013-02-27 | 杏林製薬株式会社 | ３，４−ジ置換ピロリジン誘導体の製造方法及び製造中間体 |
| EP2524911A4 (de) * | 2010-01-08 | 2013-09-11 | Kyorin Seiyaku Kk | Verfahren zur herstellung eines 3,4-disubstituierten pyrrolidinderivats und zwischenprodukt daraus |
| EP2578568A4 (de) * | 2010-05-31 | 2014-07-09 | Kyorin Seiyaku Kk | Verfahren zur herstellung von 3-substituierten 4-fluorpyrrolidin-derivaten |
| KR20130143041A (ko) | 2010-10-25 | 2013-12-30 | 교린 세이야꾸 가부시키 가이샤 | 3,4-이치환 피롤리딘 유도체의 제조 방법 |
| CN102276628A (zh) * | 2011-06-21 | 2011-12-14 | 周崇科 | 氟喹诺酮类化合物及其合成方法 |
| ES2768651T3 (es) * | 2013-04-25 | 2020-06-23 | Kyorin Seiyaku Kk | Composición farmacéutica sólida |
| BR112017019205A2 (pt) * | 2015-03-13 | 2018-04-24 | Kyorin Pharmaceutical Co., Ltd. | agente de tratamento de infecção respiratória |
| GB201708606D0 (en) | 2017-05-30 | 2017-07-12 | King S College London | Antibiotic resistance breakers |
| MY200429A (en) * | 2017-06-16 | 2023-12-26 | Kyorin Seiyaku Kk | Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess |
| EP4110758A1 (de) * | 2020-02-25 | 2023-01-04 | Tes Pharma S.r.l. | Heterocyclische verbindungen zur modulation von nr2f6 |
| CN112194667B (zh) * | 2020-11-06 | 2021-08-17 | 湖南科技大学 | 取代1,4-苯并噁嗪并二氮卓类化合物及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4822801A (en) * | 1984-07-20 | 1989-04-18 | Warner-Lambert Company | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents |
| JPS62155282A (ja) | 1985-12-27 | 1987-07-10 | Sankyo Co Ltd | ピリドベンゾオキサジンカルボン酸誘導体 |
| TW425394B (en) | 1996-04-24 | 2001-03-11 | Daiichi Seiyaku Co | Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group |
| JPH10287669A (ja) * | 1997-04-10 | 1998-10-27 | Dai Ichi Seiyaku Co Ltd | 置換アミノメチルピロリジン誘導体 |
-
2003
- 2003-03-13 JP JP2003576444A patent/JP4468701B2/ja not_active Expired - Fee Related
- 2003-03-13 AT AT03708575T patent/ATE443064T1/de not_active IP Right Cessation
- 2003-03-13 US US10/508,154 patent/US7153851B2/en not_active Expired - Fee Related
- 2003-03-13 KR KR10-2004-7014519A patent/KR20040094806A/ko not_active Ceased
- 2003-03-13 EP EP03708575A patent/EP1486500B1/de not_active Expired - Lifetime
- 2003-03-13 CN CNA038113465A patent/CN1653071A/zh active Pending
- 2003-03-13 AU AU2003213335A patent/AU2003213335B8/en not_active Ceased
- 2003-03-13 NZ NZ535182A patent/NZ535182A/en unknown
- 2003-03-13 MX MXPA04009026A patent/MXPA04009026A/es active IP Right Grant
- 2003-03-13 BR BR0308643-7A patent/BR0308643A/pt not_active IP Right Cessation
- 2003-03-13 WO PCT/JP2003/002967 patent/WO2003078439A1/ja not_active Ceased
- 2003-03-13 CA CA002478763A patent/CA2478763A1/en not_active Abandoned
- 2003-03-13 DE DE60329280T patent/DE60329280D1/de not_active Expired - Lifetime
-
2004
- 2004-09-14 NO NO20043850A patent/NO20043850L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1486500A1 (de) | 2004-12-15 |
| JPWO2003078439A1 (ja) | 2005-07-14 |
| AU2003213335B8 (en) | 2009-04-02 |
| CA2478763A1 (en) | 2003-09-25 |
| NO20043850L (no) | 2004-09-14 |
| CN1653071A (zh) | 2005-08-10 |
| JP4468701B2 (ja) | 2010-05-26 |
| AU2003213335A1 (en) | 2003-09-29 |
| US7153851B2 (en) | 2006-12-26 |
| DE60329280D1 (de) | 2009-10-29 |
| EP1486500B1 (de) | 2009-09-16 |
| WO2003078439A1 (en) | 2003-09-25 |
| US20050182052A1 (en) | 2005-08-18 |
| KR20040094806A (ko) | 2004-11-10 |
| AU2003213335B2 (en) | 2008-09-11 |
| BR0308643A (pt) | 2005-02-09 |
| EP1486500A4 (de) | 2006-02-08 |
| NZ535182A (en) | 2006-02-24 |
| MXPA04009026A (es) | 2005-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |