CY1114476T1 - Παραγωγο 7-(4-υποκατεστημενου 3-κυκλοπροπυλαμινομεθυλο-1-πυρρολιδινυλο) κινολονοκαρβοξυλικου οξεος - Google Patents

Παραγωγο 7-(4-υποκατεστημενου 3-κυκλοπροπυλαμινομεθυλο-1-πυρρολιδινυλο) κινολονοκαρβοξυλικου οξεος

Info

Publication number
CY1114476T1
CY1114476T1 CY20131100794T CY131100794T CY1114476T1 CY 1114476 T1 CY1114476 T1 CY 1114476T1 CY 20131100794 T CY20131100794 T CY 20131100794T CY 131100794 T CY131100794 T CY 131100794T CY 1114476 T1 CY1114476 T1 CY 1114476T1
Authority
CY
Cyprus
Prior art keywords
fluoro
cyclopropylaminomethyl
substituted
carboxylic acid
quinolone carboxylic
Prior art date
Application number
CY20131100794T
Other languages
English (en)
Inventor
Yoshikazu Asahina
Masaya Takei
Original Assignee
Kyorin Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd filed Critical Kyorin Pharmaceutical Co., Ltd
Publication of CY1114476T1 publication Critical patent/CY1114476T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Για παροχή νέων ενώσεων κινολονοκαρβοξυλικού οξέος οι οποίες χρησιμεύουν ως ασφαλείς, ισχυροί αντιβακτηριακοί παράγοντες οι οποίοι είναι αποτελεσματικοί έναντι ανθεκτικών σε φάρμακα βακτηρίων τα οποία είναι λιγότερο ευπαθή σε συμβατικούς αντιβακτηριακούς παράγοντες. ΜΕΣΑ ΕΠΙΛΥΣΗΣ Παρέχονται παράγωγα 7-(4-υποκατεστημένου-3-κυκλοπροπυλαμινομεθυλοπυρρολιδινυλο) κινολονοκαρβοξυλικού οξέος (όπως 1-κυκλοπροπυλο-7-[(3S,4S)-3-κυκλοπροπυλαμινομεθυλο-4-φθορο-1-πυρρολιδινυλο]-6-φθορο-1,4-διυδρο-8-μεθοξυ-4-οξο-3-κινολινοκαρβοξυλικό οξύ) τα οποία εμφανίζουν ισχυρή αντιβακτηριακή δραστικότητα έναντι gram-θετικών βακτηρίων, όπως ΜRSA, ΡRSP και VRΕ, ενώ είναι ασφαλή. Οι ενώσεις δείχνονται με τον ακόλουθο γενικό τύπο (Ι):
CY20131100794T 2003-09-10 2013-09-13 Παραγωγο 7-(4-υποκατεστημενου 3-κυκλοπροπυλαμινομεθυλο-1-πυρρολιδινυλο) κινολονοκαρβοξυλικου οξεος CY1114476T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003318897 2003-09-10
EP04787732.9A EP1666477B1 (en) 2003-09-10 2004-09-08 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) q uinolonecarboxylic acid derivative

Publications (1)

Publication Number Publication Date
CY1114476T1 true CY1114476T1 (el) 2016-10-05

Family

ID=34308537

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100794T CY1114476T1 (el) 2003-09-10 2013-09-13 Παραγωγο 7-(4-υποκατεστημενου 3-κυκλοπροπυλαμινομεθυλο-1-πυρρολιδινυλο) κινολονοκαρβοξυλικου οξεος

Country Status (18)

Country Link
US (2) US7514451B2 (el)
EP (1) EP1666477B1 (el)
JP (1) JP4639149B2 (el)
KR (1) KR101077755B1 (el)
CN (1) CN100410249C (el)
AU (1) AU2004272414B2 (el)
BR (1) BRPI0413964B8 (el)
CA (1) CA2536429C (el)
CY (1) CY1114476T1 (el)
DK (1) DK1666477T3 (el)
ES (1) ES2424676T3 (el)
NO (1) NO333481B1 (el)
NZ (1) NZ545472A (el)
PL (1) PL1666477T3 (el)
PT (1) PT1666477E (el)
SG (1) SG144936A1 (el)
SI (1) SI1666477T1 (el)
WO (1) WO2005026147A1 (el)

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WO2013145749A1 (ja) * 2012-03-29 2013-10-03 杏林製薬株式会社 カプセル製剤
JP6062422B2 (ja) * 2012-03-29 2017-01-18 杏林製薬株式会社 カプセル製剤
US9687453B2 (en) * 2013-04-25 2017-06-27 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
WO2014174848A1 (ja) * 2013-04-25 2014-10-30 杏林製薬株式会社 錠剤
US9603804B2 (en) 2013-04-25 2017-03-28 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
WO2016063542A1 (ja) * 2014-10-23 2016-04-28 杏林製薬株式会社 固形医薬組成物
WO2016148066A1 (ja) * 2015-03-13 2016-09-22 杏林製薬株式会社 呼吸器感染症治療剤
CA2987879A1 (en) * 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous drug
CA2988092A1 (en) * 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous liquid formulation
WO2016195020A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
JP6031216B1 (ja) * 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
JP6031217B1 (ja) * 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
CN106831795B (zh) * 2017-01-16 2018-12-21 石家庄学院 喹诺酮异土木香内酯衍生物及其制备和应用
WO2018230686A1 (ja) 2017-06-16 2018-12-20 杏林製薬株式会社 誤嚥性肺炎、肺化膿症又は肺膿瘍の治療剤
CN110891571A (zh) 2017-06-16 2020-03-17 杏林制药株式会社 吸入性肺炎、肺化脓或肺脓肿的治疗剂

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Publication number Publication date
US7514451B2 (en) 2009-04-07
DK1666477T3 (da) 2013-07-29
US8106072B2 (en) 2012-01-31
US20090176824A1 (en) 2009-07-09
WO2005026147A1 (ja) 2005-03-24
US20060281779A1 (en) 2006-12-14
CN100410249C (zh) 2008-08-13
EP1666477A1 (en) 2006-06-07
BRPI0413964A (pt) 2006-10-31
BRPI0413964B8 (pt) 2021-05-25
EP1666477B1 (en) 2013-07-03
CA2536429C (en) 2012-02-14
AU2004272414B2 (en) 2009-05-28
BRPI0413964B1 (pt) 2017-03-28
AU2004272414A1 (en) 2005-03-24
JP4639149B2 (ja) 2011-02-23
PT1666477E (pt) 2013-08-28
NO20061050L (no) 2006-04-04
CN1849316A (zh) 2006-10-18
NO333481B1 (no) 2013-06-24
PL1666477T3 (pl) 2013-11-29
CA2536429A1 (en) 2005-03-24
ES2424676T3 (es) 2013-10-07
KR20060123096A (ko) 2006-12-01
JPWO2005026147A1 (ja) 2007-11-08
NZ545472A (en) 2009-09-25
KR101077755B1 (ko) 2011-10-27
EP1666477A4 (en) 2008-10-22
SG144936A1 (en) 2008-08-28
SI1666477T1 (sl) 2013-10-30

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