NO20061050L - 7-(4-Substituerte-3-Cyclopropylaminometyl-1-Pyrrolidin yl)Kinolon-karboksylsyrederivater - Google Patents

7-(4-Substituerte-3-Cyclopropylaminometyl-1-Pyrrolidin yl)Kinolon-karboksylsyrederivater

Info

Publication number
NO20061050L
NO20061050L NO20061050A NO20061050A NO20061050L NO 20061050 L NO20061050 L NO 20061050L NO 20061050 A NO20061050 A NO 20061050A NO 20061050 A NO20061050 A NO 20061050A NO 20061050 L NO20061050 L NO 20061050L
Authority
NO
Norway
Prior art keywords
carboxylic acid
quinolone carboxylic
cyclopropylaminomethyl
pyrrolidinyl
substituted
Prior art date
Application number
NO20061050A
Other languages
English (en)
Other versions
NO333481B1 (no
Inventor
Yoshikazu Asahina
Masaya Takei
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of NO20061050L publication Critical patent/NO20061050L/no
Publication of NO333481B1 publication Critical patent/NO333481B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

FORMÅL Å gi nye kinolonkarboksylsyreforbindelser som fungerer som trygge, sterke antibakterielle midler som er effektive mot medikamentresistente bakterier som er mindre mottagelige for konvensjonelle antibakterielle midler. LØSNINGSMÅTE 7-(4-substituert-3-syklopropylaminometylpyrrolidinyl)kinolonkarboksylsyrederivater (så som 1-syklopropyl-7-[(3S,4S)-3-syklopropylaminometyl-4-fluor-1-pyrrolidinyl]-6-fluor-1,4-dihydro-8-metoksy-4-okso-3-kinolinkarboksylsyre) tilveiebringes som viser sterk antibakteriell aktivitet mot grampositive bakterier, så som MRSA, PRSP og VRE, mens de er trygge. Forbindelsene er vist ved den følgende generelle formel (I):
NO20061050A 2003-09-10 2006-03-03 7-(4-substituert-3-cyklopropylaminometyl-1-pyrrolidinyl)kinolonkarboksylsyrederivater, samt antibakterielt middel inneholdende samme NO333481B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003318897 2003-09-10
PCT/JP2004/013049 WO2005026147A1 (ja) 2003-09-10 2004-09-08 ７−（４−置換−３−シクロプロピルアミノメチル−１−ピロリジニル）キノロンカルボン酸誘導体

Publications (2)

Publication Number Publication Date
NO20061050L true NO20061050L (no) 2006-04-04
NO333481B1 NO333481B1 (no) 2013-06-24

Family

ID=34308537

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061050A NO333481B1 (no) 2003-09-10 2006-03-03 7-(4-substituert-3-cyklopropylaminometyl-1-pyrrolidinyl)kinolonkarboksylsyrederivater, samt antibakterielt middel inneholdende samme

Country Status (18)

Country Link
US (2) US7514451B2 (no)
EP (1) EP1666477B1 (no)
JP (1) JP4639149B2 (no)
KR (1) KR101077755B1 (no)
CN (1) CN100410249C (no)
AU (1) AU2004272414B2 (no)
BR (1) BRPI0413964B8 (no)
CA (1) CA2536429C (no)
CY (1) CY1114476T1 (no)
DK (1) DK1666477T3 (no)
ES (1) ES2424676T3 (no)
NO (1) NO333481B1 (no)
NZ (1) NZ545472A (no)
PL (1) PL1666477T3 (no)
PT (1) PT1666477E (no)
SG (1) SG144936A1 (no)
SI (1) SI1666477T1 (no)
WO (1) WO2005026147A1 (no)

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NZ603627A (en) * 2010-05-31 2014-02-28 Kyorin Seiyaku Kk Method for producing 3-substituted-4-fluoropyrrolidine derivative
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SA112330992B1 (ar) 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
WO2013145749A1 (ja) * 2012-03-29 2013-10-03 杏林製薬株式会社 カプセル製剤
JP6062422B2 (ja) * 2012-03-29 2017-01-18 杏林製薬株式会社 カプセル製剤
US9687453B2 (en) * 2013-04-25 2017-06-27 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
WO2014174848A1 (ja) * 2013-04-25 2014-10-30 杏林製薬株式会社 錠剤
US9603804B2 (en) 2013-04-25 2017-03-28 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
WO2016063542A1 (ja) * 2014-10-23 2016-04-28 杏林製薬株式会社 固形医薬組成物
WO2016148066A1 (ja) * 2015-03-13 2016-09-22 杏林製薬株式会社 呼吸器感染症治療剤
CA2987879A1 (en) * 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous drug
CA2988092A1 (en) * 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous liquid formulation
WO2016195020A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
JP6031216B1 (ja) * 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
JP6031217B1 (ja) * 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
CN106831795B (zh) * 2017-01-16 2018-12-21 石家庄学院 喹诺酮异土木香内酯衍生物及其制备和应用
WO2018230686A1 (ja) 2017-06-16 2018-12-20 杏林製薬株式会社 誤嚥性肺炎、肺化膿症又は肺膿瘍の治療剤
CN110891571A (zh) 2017-06-16 2020-03-17 杏林制药株式会社 吸入性肺炎、肺化脓或肺脓肿的治疗剂

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Also Published As

Publication number Publication date
US7514451B2 (en) 2009-04-07
DK1666477T3 (da) 2013-07-29
US8106072B2 (en) 2012-01-31
CY1114476T1 (el) 2016-10-05
US20090176824A1 (en) 2009-07-09
WO2005026147A1 (ja) 2005-03-24
US20060281779A1 (en) 2006-12-14
CN100410249C (zh) 2008-08-13
EP1666477A1 (en) 2006-06-07
BRPI0413964A (pt) 2006-10-31
BRPI0413964B8 (pt) 2021-05-25
EP1666477B1 (en) 2013-07-03
CA2536429C (en) 2012-02-14
AU2004272414B2 (en) 2009-05-28
BRPI0413964B1 (pt) 2017-03-28
AU2004272414A1 (en) 2005-03-24
JP4639149B2 (ja) 2011-02-23
PT1666477E (pt) 2013-08-28
CN1849316A (zh) 2006-10-18
NO333481B1 (no) 2013-06-24
PL1666477T3 (pl) 2013-11-29
CA2536429A1 (en) 2005-03-24
ES2424676T3 (es) 2013-10-07
KR20060123096A (ko) 2006-12-01
JPWO2005026147A1 (ja) 2007-11-08
NZ545472A (en) 2009-09-25
KR101077755B1 (ko) 2011-10-27
EP1666477A4 (en) 2008-10-22
SG144936A1 (en) 2008-08-28
SI1666477T1 (sl) 2013-10-30

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