ATE442354T1 - Pyrrolidinderivate als oxytocin antagonisten - Google Patents
Pyrrolidinderivate als oxytocin antagonistenInfo
- Publication number
- ATE442354T1 ATE442354T1 AT03762692T AT03762692T ATE442354T1 AT E442354 T1 ATE442354 T1 AT E442354T1 AT 03762692 T AT03762692 T AT 03762692T AT 03762692 T AT03762692 T AT 03762692T AT E442354 T1 ATE442354 T1 AT E442354T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- pyrrolidine derivatives
- oxytocin antagonists
- sup
- forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02100784 | 2002-07-05 | ||
| PCT/EP2003/050286 WO2004005249A1 (en) | 2002-07-05 | 2003-07-04 | Pyrrolidine derivatives as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442354T1 true ATE442354T1 (de) | 2009-09-15 |
Family
ID=30011225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03762692T ATE442354T1 (de) | 2002-07-05 | 2003-07-04 | Pyrrolidinderivate als oxytocin antagonisten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7115754B2 (de) |
| EP (1) | EP1532109B1 (de) |
| JP (1) | JP4851085B2 (de) |
| CN (1) | CN1330633C (de) |
| AT (1) | ATE442354T1 (de) |
| BR (1) | BR0312586A (de) |
| CA (1) | CA2487532C (de) |
| DE (1) | DE60329189D1 (de) |
| EA (1) | EA008479B1 (de) |
| ES (1) | ES2330841T3 (de) |
| HK (1) | HK1076107A1 (de) |
| HR (1) | HRP20041208A2 (de) |
| IL (1) | IL166103A0 (de) |
| MX (1) | MXPA05000326A (de) |
| NO (1) | NO20050612L (de) |
| PL (1) | PL374666A1 (de) |
| RS (1) | RS115804A (de) |
| UA (1) | UA78058C2 (de) |
| WO (1) | WO2004005249A1 (de) |
| ZA (1) | ZA200409820B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL159219A0 (en) * | 2001-06-18 | 2004-06-01 | Applied Research Systems | Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
| US10722645B2 (en) | 2011-12-21 | 2020-07-28 | Deka Products Limited Partnership | Syringe pump, and related method and system |
| EP2845850A1 (de) * | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidinderivate als Oxytocin/Vasopressin-V1a-Rezeptorantagonisten |
| EP2886107A1 (de) | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Orale Formulierungen von Pyrrolydinderivaten |
| MX371068B (es) | 2014-07-02 | 2020-01-15 | ObsEva SA | ((3z,5s)-5-(hidroximetil)-1-[(2'-metil-1,1'-bifenil-4-il)carbonil ]pirrolidin-3-ona o-metiloxima cristalina y métodos de uso de la misma. |
| EP3501533A1 (de) | 2014-12-22 | 2019-06-26 | Ferring B.V. | Oxytocin-rezeptor-antagonistische therapie in der lutealen phase für implantation und schwangerschaft bei frauen, welche sich assistierten reproduktivtechnologien unterziehen |
| JP6933322B2 (ja) | 2016-01-04 | 2021-09-08 | メルク セローノ エス．エー． | ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形 |
| UA127283C2 (uk) | 2016-07-21 | 2023-07-12 | Обсева С.А. | Спосіб застосування антагоніста окситоцину для сприяння імплантації ембріона і запобігання викидню |
| CN114667141A (zh) | 2019-09-03 | 2022-06-24 | 奥布赛瓦股份公司 | 用于促进胚胎移植和预防流产的催产素拮抗剂给药方案 |
| AU2021218895A1 (en) | 2020-02-10 | 2022-09-15 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| BR0109900A (pt) * | 2000-03-27 | 2003-06-03 | Applied Research Systems | Derivados de pirolidina farmaceuticamente ativos, uso de derivados de pirolidina, composição farmacêutica e processo para preparação de um derivado de pirolidina |
-
2003
- 2003-04-07 UA UA20041210895A patent/UA78058C2/uk unknown
- 2003-07-04 CA CA2487532A patent/CA2487532C/en not_active Expired - Fee Related
- 2003-07-04 CN CNB038204010A patent/CN1330633C/zh not_active Expired - Fee Related
- 2003-07-04 US US10/518,543 patent/US7115754B2/en not_active Expired - Lifetime
- 2003-07-04 ES ES03762692T patent/ES2330841T3/es not_active Expired - Lifetime
- 2003-07-04 PL PL03374666A patent/PL374666A1/xx not_active Application Discontinuation
- 2003-07-04 JP JP2004518783A patent/JP4851085B2/ja not_active Expired - Fee Related
- 2003-07-04 BR BR0312586-6A patent/BR0312586A/pt not_active IP Right Cessation
- 2003-07-04 EP EP03762692A patent/EP1532109B1/de not_active Expired - Lifetime
- 2003-07-04 MX MXPA05000326A patent/MXPA05000326A/es active IP Right Grant
- 2003-07-04 AT AT03762692T patent/ATE442354T1/de not_active IP Right Cessation
- 2003-07-04 RS YUP-1158/04A patent/RS115804A/sr unknown
- 2003-07-04 WO PCT/EP2003/050286 patent/WO2004005249A1/en active Application Filing
- 2003-07-04 EA EA200500133A patent/EA008479B1/ru not_active IP Right Cessation
- 2003-07-04 DE DE60329189T patent/DE60329189D1/de not_active Expired - Lifetime
-
2004
- 2004-12-03 ZA ZA200409820A patent/ZA200409820B/en unknown
- 2004-12-23 HR HR20041208A patent/HRP20041208A2/xx not_active Application Discontinuation
-
2005
- 2005-01-03 IL IL16610305A patent/IL166103A0/xx unknown
- 2005-02-03 NO NO20050612A patent/NO20050612L/no not_active Application Discontinuation
- 2005-11-17 HK HK05110274A patent/HK1076107A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0312586A (pt) | 2005-04-12 |
| DE60329189D1 (de) | 2009-10-22 |
| CA2487532A1 (en) | 2004-01-15 |
| US7115754B2 (en) | 2006-10-03 |
| US20060004020A1 (en) | 2006-01-05 |
| EP1532109A1 (de) | 2005-05-25 |
| PL374666A1 (en) | 2005-10-31 |
| NO20050612L (no) | 2005-02-03 |
| MXPA05000326A (es) | 2005-03-31 |
| WO2004005249A1 (en) | 2004-01-15 |
| EA008479B1 (ru) | 2007-06-29 |
| UA78058C2 (en) | 2007-02-15 |
| RS115804A (en) | 2007-02-05 |
| ZA200409820B (en) | 2006-07-26 |
| JP4851085B2 (ja) | 2012-01-11 |
| HRP20041208A2 (en) | 2005-06-30 |
| HK1076107A1 (en) | 2006-01-06 |
| CA2487532C (en) | 2011-03-08 |
| JP2005533828A (ja) | 2005-11-10 |
| CN1330633C (zh) | 2007-08-08 |
| CN1678576A (zh) | 2005-10-05 |
| EP1532109B1 (de) | 2009-09-09 |
| EA200500133A1 (ru) | 2005-08-25 |
| IL166103A0 (en) | 2006-01-15 |
| AU2003254498A1 (en) | 2004-01-23 |
| ES2330841T3 (es) | 2009-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |